Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis

Galliera, Emanuela; Massaccesi, Luca; Banfi, Giuseppe; Vecchi, Elena De; Ragone, Vincenza; Romanelli, Massimiliano Marco Corsi

doi:10.1007/s12018-021-09278-7

Cited by 8 publications

(5 citation statements)

References 126 publications

(146 reference statements)

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“…There is, however, surprisingly limited knowledge on the influence of the biomechanical environment in the bone and bone-implant interface on the redox balance, with some of the information available based on maxillofacial implantology focusing on the effects of the implant itself. It is recognized that ROS boost the inflammatory response and cause both RANKL-induced osteoclastogenesis and osteoblast apoptosis, leading to periprosthetic osteolysis aseptic loosening, the most frequent cause of implant failure ( Borys et al, 2018 ; Ozawa et al, 2020 ; Galliera et al, 2021 ). Bone unloading such as observed in disuse and microgravity conditions leads to decreased bone mass and quality, through redox-mediated pathways.…”

Section: Discussionmentioning

confidence: 99%

In Sickness and in Health: The Oxygen Reactive Species and the Bone

Reis

Ramos

2021

Front. Bioeng. Biotechnol.

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Oxidative stress plays a central role in physiological and pathological bone conditions. Its role in signalment and control of bone cell population differentiation, activity, and fate is increasingly recognized. The possibilities of its use and manipulation with therapeutic goals are virtually unending. However, how redox balance interplays with the response to mechanical stimuli is yet to be fully understood. The present work summarizes current knowledge on these aspects, in an integrative and broad introductory perspective.

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Section: Discussionmentioning

confidence: 99%

In Sickness and in Health: The Oxygen Reactive Species and the Bone

Reis

Ramos

2021

Front. Bioeng. Biotechnol.

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“…It has been shown to reduce lipid peroxidation in the brain of D-galactose-induced aged rats 50 . It has been reported that oxidative stress and inflammation stimulate osteoclast differentiation, resulting in increased bone resorption 51 , 52 , implying that the reduction in Oc.S/BS in the current study could be due to the antioxidant and anti-inflammatory activity of KSLP. For bone remodelling markers, significant differences between KSLP groups and other groups prior to treatment were noted.…”

Section: Discussionmentioning

confidence: 99%

Normalisation of High Bone Remodelling due to Oestrogen Deficiency by Traditional Chinese Formulation Kang Shuai Lao Pian in Ovariectomised Rats

Ekeuku¹,

Chin²,

Qian³

et al. 2022

Int. J. Med. Sci.

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Postmenopausal osteoporosis transpires due to excessive osteoclastic bone resorption and insufficient osteoblastic bone formation in the presence of oestrogen insufficiency. Kang Shuai Lao Pian (KSLP) is a red ginseng-based traditional Chinese medicine known for its anti-ageing properties. However, studies on its effect on bone loss are lacking. Thus, the current study examined the skeletal protective effects of KSLP in an ovariectomised rodent bone loss model. Three-month-old female Sprague Dawley rats (n=42) were randomised into baseline, sham and ovariectomised (OVX) groups. The OVX rats were supplemented with low- (KSLP-L; 0.15 g/kg), medium- (KSLP-M; 0.30 g/kg), high-dose KSLP (KSLP-H; 0.45 g/kg) or calcium carbonate (1% w/v). The daily supplementation of KSLP was performed via oral gavage for eight weeks. Gavage stress was stimulated in the ovariectomised control with distilled water. The rats were euthanised at the end of the study. Whole-body and femoral bone mineral content and density scans were performed at baseline and every four weeks. Blood samples were obtained for the determination of bone remodelling markers. Histomorphometry and biomechanical strength testing were performed on femurs and tibias. High bone remodelling typically due to oestrogen deficiency, indicated by the elevated bone formation and resorption markers, osteoclast surface, single-labelled surface and mineralising surface/bone surface ratio, was observed in the untreated OVX rats. Whole-body BMD adjusted to body weight and Young's modulus decreased significantly in the untreated OVX rats. High-dose KSLP supplementation counteracted these degenerative changes. In conclusion, KSLP improves bone health by normalising bone remodelling, thereby preventing bone loss and decreased bone strength caused by oestrogen deficiency. Its anti-osteoporosis effects should be validated in patients with postmenopausal osteoporosis.

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“…Uncontrollable bone-related complications like osteoporosis, osteoarthritis, rheumatoid arthritis, bone cancer, and many other bone disorders are instigated by an interruption in these pathways (Barnsley et al, 2021). Although oxidative strain has been related to the development of osteoblasts, vital for bone health, extreme oxidative strain stimulates osteoclast discrepancy while conquering osteoblast genesis (Galliera et al, 2021). Correspondingly, inflammation, which is essential for the remodeling of bones, inclines the bone to compulsive stress and becomes chronic, as observed in postmenopausal women and older men (Xie et al, 2019) because of lesser total antioxidant capability and greater inflammation as compared to healthy people (Epsley et al, 2021).…”

Section: Bone and Joint Healthmentioning

confidence: 99%

Plant protein-derived peptides: frontiers in sustainable food system and applications

Nirmal,

Khanashyam,

Shah

et al. 2024

Front. Sustain. Food Syst.

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Plant proteins have been considered a potential source of bio-functional peptides, which can be beneficial for human health. The potent antioxidant properties of plant-based peptides protect against oxidative damage and associated diseases. Despite a significant number of studies on the preparation and biological functions of plant-based peptides, only a limited number of peptides are commercially utilized. The systematic studies of the extraction, optimization, isolation, pharmacokinetics, stability, and safety aspects of plant protein-derived peptides (PPDP) are in progress. Also, the molecular mechanism of action and health benefits of bioactive PPDP is still lacking. Hence, this review provides a comprehensive discussion of various plant protein sources to end-product applications of PPDP. In this context, different plant sources explored for functional and bioactive PPDP have been presented. The green biotechnological techniques such as fermentation and enzymatic hydrolysis for extraction of PPDP have been described. The functional and biological properties of PPDP have been revisited. The most important part of the application which includes the stability and bioavailability of PPDP has been discussed. Additionally, the health impact of PPDP administration has been summarized. Lastly, future perspectives and concluding remarks have been documented.

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Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis

Cited by 8 publications

References 126 publications

In Sickness and in Health: The Oxygen Reactive Species and the Bone

In Sickness and in Health: The Oxygen Reactive Species and the Bone

Normalisation of High Bone Remodelling due to Oestrogen Deficiency by Traditional Chinese Formulation Kang Shuai Lao Pian in Ovariectomised Rats

Plant protein-derived peptides: frontiers in sustainable food system and applications

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