Effect of ovarian steroids and oxytocin on the production of prostaglandin E2, prostaglandin F2α and endothelin-1 from cow oviductal epithelial cell monolayers in vitro

Wijayagunawardane, Missaka P.B.; Choi, Young-Ho; Miyamoto, Akio; Kamishita, H; Fujimoto, S.; Takagi, Mitsuhiro; Sato, Kunitada

doi:10.1016/s0378-4320(99)00021-4

Cited by 36 publications

(25 citation statements)

References 21 publications

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“…The oviduct has a capacity to generate PG from both endogenous and exogenous substrate such as arachidonic acid [29], and PG production in the cow oviduct was stimulated by various substances including luteinizing hormone (LH), E2, ET-1, Ang II and atrial natriuretic peptide [28,[30][31][32]. Our resent experiments demonstrated that the infusion of TNFα into microdialyzed cow oviducts collected during the follicular and postovulatory stages clearly stimulated release of PG [8].…”

Section: Involvement Of Tnfα In the Regulation Of Cyclic Oviductal Comentioning

confidence: 97%

Tumor Necrosis Factor .ALPHA. System in the Bovine Oviduct: A Possible Mechanism for Embryo Transport

Wijayagunawardane

Miyamoto

2004

Journal of Reproduction and Development

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Abstract. Active contractile pattern of the oviduct occurs during the periovulatory period for the movement of the gamete/embryo, which is strictly regulated by endocrine and paracrine/autocrine factors. In this review, an involvement of tumor necrosis factor α (TNFα) in the regulation of cow oviductal contraction is discussed. Oviductal epithelial cells express TNFα ligand and it's both receptor types; high expression during the follicular and postovulatory stages, while low expression during luteal stage and thus, TNFα system in the cow oviduct is most active during the periovularoty period. The immune cells present in large numbers in the oviduct during the periovulatory period of the estrus cycle, and these cells are also considered as another potential source for the TNFα in the oviduct. Using in vitro models, TNFα clearly stimulated local production and release of contraction related substances such as prostaglandins (PGs), endothelin-1 (ET-1) and angiotensin II (Ang II). Since these substances have been shown to activate directly the oviductal contraction in vitro, TNFα appears to stimulate the oviductal contraction during the periovulatory period and contribute to create an optimal local environment suitable for gamete/embryo transport. In addition, the ability of embryo to act as a source of TNFα in the oviduct cannot be excluded. To support this idea, the embryo at 2-4 cells stages indeed express TNFα, so that the minute quantities of TNFα secreted by the embryo may further acts locally to enhance the production of PG, ET-1 and Ang II in the oviduct, which may result in an active oviductal contraction in the microenvironment around the embryo. This may ensure the embryo to migrate into the uterus at the optimal time.

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Section: Involvement Of Tnfα In the Regulation Of Cyclic Oviductal Comentioning

confidence: 97%

Tumor Necrosis Factor .ALPHA. System in the Bovine Oviduct: A Possible Mechanism for Embryo Transport

Wijayagunawardane

Miyamoto

2004

Journal of Reproduction and Development

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“…Although there is solid evidence that hormonal state of the female hamster participates in the regulation of ovum transport in mammals (Erb & Wynne-Edwards 1993, Croxatto 2002, the differential velocities of oviduct transport of fertilized and unfertilized ova in several mammalian species (Ortiz et al 1986) originated the hypothesis that ovum itself is capable of regulating its own development and transport in the early stages of embryo development. In accord with this hypothesis, there have been some recent reports showing that the embryo regulates its own development and transport by the secretion of some active factors like platelet-activating factor (PAF) (Velasquez et al 2001), some other eicosanoids (Wijayagunawardane et al 1999) and nitric oxide (Gouge et al 1998, Chen et al 2001, Tranguch et al 2003.…”

mentioning

confidence: 87%

Effect of maternal age and parity on preimplantation embryo development and transport in the golden hamster (Mesocricetus auratus)

et al. 2005

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SummaryPreimplantation embryo development was studied in the golden hamster (Mesocricetus auratus). Three groups of regularly cycling female hamsters were used: (I) 30 nulliparous young female (NYF) hamsters; (II) 24 nulliparous adult female (NAF) hamsters and (III) 30 multiparous adult female (MAF) hamsters. Female hamsters were mated with male hamsters of proven fertility. Only 15 min were allowed for mating. The moment of ejaculation was registered. Female hamsters were killed from 60 to 69 h after coitus. Corpora lutea were counted in both ovarian surfaces. Oviducts and uterine horns were flushed separately and embryo number, stage of development and distribution were recorded. Adult female hamsters, nulliparous and multiparous, had significant higher ovulation rates than NYF, but their reproductive efficiency was significantly lower. Preimplantation embryo development and transport were highly synchronous in NYF, but not in adults. Morulae were observed in NYF as early as 62-63 h after coitus. In adult female hamsters, significant numbers of morulae were found until 66-67 h. On the contrary, in NYF four-cell embryos were detected only until 60-61 h, while four-cell embryos were found until 64-65 h in NAF, and until 66-67 h in MAF. Embryo transport from the oviduct to the uterus is practically completed at 62-63 h after coitus in NYF, while it is evidently retarded in adult animals. In NYF all eight-cell embryos reached the uterus by 62 h after coitus. In adult female hamsters, both nulliparous and multiparous, a considerable number of eight-cell embryos fail to migrate into the uterus even at 67 h after coitus.

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“…The transport of gametes and embryos is induced by alternate waves of contraction and relaxation of the oviductal smooth muscle and the ciliary beating of oviductal epithelial cells (Halbert et al 1976, Hunter 2012. Various substances including nitric oxide (NO), ovarian steroids, and prostaglandins (PGs) regulate the waves of contraction and relaxation (Helm et al 1982, Rosselli et al 1994, Ekerhovd et al 1997, 1999, Al-Alem et al 2007.…”

Section: Introductionmentioning

confidence: 99%

“…Ovarian steroids are major molecules controlling oviductal functions (Wijayagunawardane et al 1999, Ulbrich et al 2003, Szóstek et al 2011. During the estrous cycle except at ovulation, these steroids participate in oviductal physiological events via systemic way.…”

Section: Introductionmentioning

confidence: 99%

Regulation of bovine oviductal NO synthesis by follicular steroids and prostaglandins

et al. 2016

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Nitric oxide (NO) is a regulator of sperm motility, oocyte/embryo survival, and waves of contraction/relaxation in mammalian oviducts. As follicles control oviductal functions by two routes at least, (1) a systemic way via blood vessels before ovulation, (2) a direct way by entering of follicular fluid through fimbria at ovulation, we hypothesized that NO synthesis in the bovine oviduct is regulated by follicular steroids and prostaglandins (PGs). Quantification of mRNA expressions in the ampullary tissues showed that inducible NO synthase (NOS2) mRNA expression was highest on the day of ovulation (day 0). By contrast, NOS2 mRNA expression in the isthmus was highest on days 5-6 and lowest on days 19-21. Endothelial NOS (NOS3) mRNA expressions in either the ampulla or the isthmus did not change during the estrous cycle. PGE2 and PGF2α increased NOS2 mRNA expressions in cultured ampullary oviductal epithelial cells after 1-h incubation. These increases were suppressed by an antagonist of E-prostanoid receptor type 2, one of the PGE2 receptor. Estradiol-17β decreased the expression of NOS2 mRNA expression in cultured isthmic epithelial cells 24 h after treatment. This effect was suppressed by an antagonist of estrogen receptor α (ESR1). Expression of ESR1 was highest on days 19-21 in the isthmic tissues. The overall findings indicate region-specific difference of NO synthesis in the oviduct. PGs flowed from ruptured follicle may up-regulate NO synthesis in the oviductal epithelium, whereas circulating E2 seems to inhibit NO synthesis via ESR1 in the isthmus at the follicular stage.Reproduction (2016) 151 577-587

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Effect of ovarian steroids and oxytocin on the production of prostaglandin E2, prostaglandin F2α and endothelin-1 from cow oviductal epithelial cell monolayers in vitro

Cited by 36 publications

References 21 publications

Tumor Necrosis Factor .ALPHA. System in the Bovine Oviduct: A Possible Mechanism for Embryo Transport

Tumor Necrosis Factor .ALPHA. System in the Bovine Oviduct: A Possible Mechanism for Embryo Transport

Effect of maternal age and parity on preimplantation embryo development and transport in the golden hamster (Mesocricetus auratus)

Regulation of bovine oviductal NO synthesis by follicular steroids and prostaglandins

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