Effect of Orally Administered Camel Milk in Alloxan® Induced Albino Rats: Long Term Study on Maternal Uterus and Neonates Selected Organs

Ateeq, Muhammad Khalil

doi:10.29261/pakvetj/2018.114

Cited by 4 publications

(1 citation statement)

References 20 publications

(22 reference statements)

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“…Albeit the progesterone concentration was not determined in this study, it should be related with the altered uterine histomorphometry and decreased foetal weight. Moreover, the foetal weight is also affected by the diabetes induced hyperketonaemia and the syncytial fibrosis of the placenta (Amaral et al 2008;Ateeq et al 2019).…”

Section: Discussionmentioning

confidence: 99%

The effects of long-term diabetes on the haematological and uterine indicators and their association with neonatal nephrogenesis counter-protected by camel milk: A time dependent study

Usman¹,

Qureshi²,

Ali³

et al. 2020

Vet. Med. - Czech

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The novelty of this project is to describe how chronic diabetes altered the haematological and uterine indicators in a time dependent-manner that were reversed by camel milk (CM) therapy in pregnant and non-pregnant rat models. Fifty-four female rats were divided into three groups: Placebo (N), diabetic control (DC) and diabetic treated (DT) with CM at 40 ml/kg/24 h for 90 days. A single intact male was introduced into every group for mating at day 60 of the experiment. The sample collection was undertaken at day 30 and 60 of the non-pregnant rats and at day 90 immediately after parturition for the pregnant rats. At every collection, the dam’s blood, as well as the uteri and neonatal kidneys were collected and subjected to a paraffin tissue preparation technique for a histological evaluation. The data revealed that at day 30, the uterine endo- and myometrium remained unaffected by diabetes, but at day 60, a significant reduction in the uterine indicators from diabetes was observed. However, the CM restored the uterine histology in the DT. At 90 day, chronic diabetes showed (P < 0.05) a harmful effect on the pregnant uterus which was reversed (P < 0.05) by the CM. The RBC (red blood cell) indices, platelets, and leucocyte counts were severely affected by the diabetes and protected by the CM at every point of collection. The kidney tissues of the neonate rats, delivered by the dams, in the DC presented a significant (P < 0.05) shrinkage in the cortex and glomeruli while the CM potentially reversed these changes. These results will help to understand the chronic diabetes effects on the uterus and neonate’s renal genesis, and the role of camel milk in the management of chronic pre-gestational diabetes.

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Section: Discussionmentioning

confidence: 99%

The effects of long-term diabetes on the haematological and uterine indicators and their association with neonatal nephrogenesis counter-protected by camel milk: A time dependent study

Usman¹,

Qureshi²,

Ali³

et al. 2020

Vet. Med. - Czech

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Effect of ethanolic preparations of cinnamon (Cinnamomum zeylanicum) extract on hematologic and histometric parameters of selected organs in Alloxan® induced diabetic female albino rats

Qureshi

Ghaffor

Usman

et al. 2019

J Diabetes Metab Disord

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Short term therapeutic efficacy of camel milk Vis-À-Vis buffalo milk in Alloxan® induced diabetic rabbits

Deeba

Qureshi

Kamran

et al. 2020

J Diabetes Metab Disord

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Effect of Orally Administered Camel Milk in Alloxan® Induced Albino Rats: Long Term Study on Maternal Uterus and Neonates Selected Organs

Abstract: To Cite This Article: Ateeq MK, AS Qureshi, M Usman, RU Shahid and WA Khamas, 2019. Effect of orally administered camel milk in alloxan® induced albino rats: long term study on maternal uterus and neonates selected organs. Pak Vet J, 39(1): 81-85. http://dx.

Cited by 4 publications

References 20 publications

The effects of long-term diabetes on the haematological and uterine indicators and their association with neonatal nephrogenesis counter-protected by camel milk: A time dependent study

The effects of long-term diabetes on the haematological and uterine indicators and their association with neonatal nephrogenesis counter-protected by camel milk: A time dependent study

Effect of ethanolic preparations of cinnamon (Cinnamomum zeylanicum) extract on hematologic and histometric parameters of selected organs in Alloxan® induced diabetic female albino rats

Short term therapeutic efficacy of camel milk Vis-À-Vis buffalo milk in Alloxan® induced diabetic rabbits

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