Effect of Oral Prednisolone on Visual Outcomes and Complications after Scleral Buckling

Dehghan, Mohammad Hossein; Ahmadieh, Hamid; Soheilian, Masoud; Azarmina, Mohsen; Moradian, Siamak; Ramezani, Alireza; Tavallal, Ali; Naghibozakerin, J.

doi:10.1177/112067211002000224

Cited by 26 publications

(32 citation statements)

References 13 publications

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“…3 Rates of eyes with cellophane appearance depending on number of cryocoagulation spots 77% in controls to 14% [11]. In humans, systemic steroids starting at the day after scleral buckling surgery did not reduce postoperative complications in a randomized placebo-controlled study, but the study was not powered to allow conclusions with regard to a steroid effect on the development of PVR [12]. PVR rates of 4 % in the steroid group and 11 % in the control group in this study are apparently too small for reliable statistical evidence.…”

Section: Discussionmentioning

confidence: 97%

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Systemic corticosteroids reduce the risk of cellophane membranes after retinal detachment surgery: a prospective randomized placebo-controlled double-blind clinical trial

Koerner

Koerner-Stiefbold

Garweg

2012

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 97%

“…Local injections of triamcinolone acetonide and systemic administration of steroids against PVR reactions have been tested experimentally and in humans [9][10][11][12][13]. The combination of systemic methylprednisolone, sodium diclofenac and colchicine reduced significantly the rate of PVR-induced retinal detachment in rabbits [14].…”

Section: Introductionmentioning

confidence: 98%

Systemic corticosteroids reduce the risk of cellophane membranes after retinal detachment surgery: a prospective randomized placebo-controlled double-blind clinical trial

Koerner

Koerner-Stiefbold

Garweg

2012

Graefes Arch Clin Exp Ophthalmol

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“…10 Oral steroid intakes that supposedly suppress TGF-b activity did not robustly contribute to the prevention of PVR in surgical RD cases. 11,12 Therefore, a better understanding of the precise mechanism and the discovery of a novel therapeutic target for PVR is necessary.…”

mentioning

confidence: 99%

Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy

Nagasaka

Kaneko

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Proliferative vitreoretinopathy (PVR) is one of the most severe ocular diseases. Fibrotic changes in retinal cells are considered to be involved in the pathogenesis of PVR. Epithelial-mesenchymal transition (EMT) of RPE cells is one of the main concepts in the pathogenesis of fibrovascular membranes (FVMs) in PVR. In this study, we examined the expression of Caveolin-1 in human FVMs from patients with PVR. We also examined the role of Caveolin-1 in the pathogenesis of PVR.METHODS. Western blotting, real-time PCR, and immunohistochemistry were performed with human FVMs and mouse eyes with PVR. Cell migration assays were performed to evaluate the involvement of Caveolin-1 in EMT using primary human and mouse RPE cells. RESULTS.Caveolin-1 was expressed in human FVMs and upregulated in the mouse eyes with PVR. The alpha-smooth muscle actin (aSMA) expression and migration ability were increased in RPE cells with knockout or knockdown of Caveolin-1, whereas zonula occludens-1 (ZO-1) immunohistochemistry showed reduced morphology and expression of ZO-1. In addition, migration assays showed that Caveolin-1 reduction increased RPE cell migration abilities.CONCLUSIONS. These results indicated that Caveolin-1 in RPE cells prevents PVR by blocking EMT.

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“…One way to enhance the role of adjuvant steroid therapy is to use a sustained-release delivery system. Few prospective clinical trials involving steroids as adjuvant therapy for RD have been reported [18,19,37]. More studies on this important issue are necessary to formulate definitive conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, steroids have been used to alleviate postoperative inflammation; however, the benefits of steroids for PVR prevention are controversial [17,18,19]. Additionally, their effect on the glial reaction has not been thoroughly investigated.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Ozurdex® (Dexamethasone Intravitreal Implant) on Experimental Proliferative Vitreoretinopathy

Kuo

Chen

et al. 2015

Ophthalmologica

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Purpose: To investigate a new sustained-release formulation of dexamethasone (Ozurdex®) for inhibiting proliferative vitreoretinopathy (PVR) and its effect on the expression of retinal glial reaction and inflammation in experimental PVR eyes. Methods: We used 30 pigmented rabbits for this study. One week after gas compression, the eyes were injected with 5 × 10⁴ retinal pigment epithelial cells into the vitreous cavity to induce PVR. Concurrently, one eye also received an intravitreal injection of Ozurdex; the other eye was used as a control. PVR was graded by indirect ophthalmoscopy on days 1, 3, 7, 14, 21, and 28. The expression of the retinal glial reaction and inflammation in experimental PVR eyes were evaluated by Western blot analysis. Results: PVR severity increased gradually and peaked after 14 days, and no differences in PVR severity between the study and control groups were observed at any time point. The expression of glial fibrillary acid protein (GFAP) increased on days 7 and 14 in both the PVR control and study groups. While the use of Ozurdex in the study group showed less GFAP expression, this difference was not significant. The expression of tumor necrosis factor (TNF)-α and interleukin (IL)-6 significantly increased on days 7 and 14 in PVR control eyes. There was a significant difference in TNF-α between PVR control eyes and Ozurdex-treated eyes on days 7 (p < 0.001) and 14 (p = 0.019). Ozurdex in the study group showed lower IL-6 expression; however, this difference was not significant on days 7 (p = 0.063) and 14 (p = 0.052). Conclusions: The intravitreal injection of Ozurdex suppressed the expression of inflammatory markers; however, it did not mitigate the severity of experimental PVR in this animal model.

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Effect of Oral Prednisolone on Visual Outcomes and Complications after Scleral Buckling

Abstract: Postoperative oral prednisolone does not seem to improve the visual outcomes and complications of scleral buckling in simple phakic RRD.

Cited by 26 publications

References 13 publications

Systemic corticosteroids reduce the risk of cellophane membranes after retinal detachment surgery: a prospective randomized placebo-controlled double-blind clinical trial

Systemic corticosteroids reduce the risk of cellophane membranes after retinal detachment surgery: a prospective randomized placebo-controlled double-blind clinical trial

Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy

The Effects of Ozurdex® (Dexamethasone Intravitreal Implant) on Experimental Proliferative Vitreoretinopathy

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