Effect of oral methionine on tissue lipid peroxidation and antioxidants in alloxan-induced diabetic rats

Anuradha, Carani Venkatraman; Selvam, Ramasamy

doi:10.1016/0955-2863(93)90054-z

Cited by 71 publications

(51 citation statements)

References 25 publications

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“…GSH, known to protect the cellular system against the toxic effects of lipid peroxidation acts as a direct free radical scavenger (Meister & Anderson, 1983). The lower levels of GSH seen in the diabetic control group may represent increased utilization due to oxidative stress (Anuradha & Selvam, 1993). Hyperglycemia increases the polyol pathway, advanced glycation end products formation, and free radical generation rates leading to increased GSH oxidation (McLennan et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Effect ofGaruga pinnata. Roxb Aqueous Bark Extract on Tissue Antioxidant Activity in Streptozotocin-Nicotinamide–Induced Type II Diabetic Rats

Shirwaikar

Rajendran

Barik

2007

Pharmaceutical Biology

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Oxidative stress plays an important role in chronic complications of diabetes mellitus. In the current study, the antioxidant effect of oral administration of aqueous bark extract of Garuga pinnata Roxb. (Burseraceae) on tissue antioxidant enzymes and lipid peroxidation in liver and kidney of streptozotocin-nicotinamide-induced type II diabetic rats was evaluated. The diabetic rats showed lower activities of superoxide dismutase (SOD), glutathione peroxidase, glutathione transferase, and reduced glutathione content in liver and kidney, which were restored to near normal levels by treatment with the bark extract. The increased levels of lipid peroxidation (TBARS) in diabetic rats were reverted back to near normal levels after treatment with the bark extract. A two dose level study was conducted. The current study reveals the efficacy of Garuga pinnata aqueous bark extract in the amelioration of diabetes, which may be attributed to its antioxidant potential.

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Section: Discussionmentioning

confidence: 99%

Effect ofGaruga pinnata. Roxb Aqueous Bark Extract on Tissue Antioxidant Activity in Streptozotocin-Nicotinamide–Induced Type II Diabetic Rats

Shirwaikar

Rajendran

Barik

2007

Pharmaceutical Biology

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“…Reduced glutathione, a major endogenous antioxidant, plays a crucial role in the antioxidant defense (39). Vitamin C, a major extra cellular non-enzymatic antioxidant, has crucial role in scavenging several reactive oxygen species.…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic and antilipidperoxidative effects ofTephrosia purpurea seed extract in streptozotocin induced diabetic rats

Pavana

Sethupathy

Manoharan

2007

Indian J Clin Biochem

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“…Our results also suggest that cisplatin-treated rats may be less resistant and more susceptible to lipid peroxidation in the presence of promoters like ascorbate and ferrous sulphate [31]. So, it is possible that cisplatin could produce free radicals that cause subsequent lipid peroxidation to an acceptable extent.…”

Section: Discussionmentioning

confidence: 59%

Protective Role of Vitamin E and Acetazolamide in Cisplatin-Induced Changes in Lipid Peroxidation and Antioxidant Enzyme Levels in Albino Rats.

Gopalakrishnan

Murugesan

Babu

et al. 1996

J. Clin. Biochem. Nutr.

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SummaryCisplatin, an antitumor chemotherapeutic agent with doselimiting nephrotoxic side effects, was administered i.p, to male albino rats at a concentration of 6 mg/kg body wt. The antioxidant vitamin E (400 mg/kg body wt., orally) and the diuretic acetazolamide (ACZ) (20 mg/ kg body wt., i.p.) were co-administered as modulators. The effect of cisplatin on lipid peroxidation and antioxidant enzyme levels was then examined. The agent increased the level of lipid peroxidation and significantly decreased the activities of antioxidant enzymes. These effects may have been due to the formation of free radicals and were considered to be one of the reasons for cisplatin-induced nephrotoxicity. Interestingly, these changes were found to be very much counteracted by vitamin E and acetazolamide when they were co-administered along with the cisplatin. Hence, we suggest that co-administration of vitamin E and acetazolamide along with cisplatin will be clinically advantageous in attenuating cisplatin-induced nephrotoxicity during chemotherapy. Cisplatin (cis-diammine dichloro platinum-II), a platinum containing coordination complex, is an antitumor agent with proven efficacy as a single agent against a wide spectrum of malignancies [1]. Toxicological studies in humans and animals indicate that higher doses produce enzyme inhibition and histological changes in liver, kidney, gastrointestinal tract, and bone marrow [2]. However, the chief dose-limiting side effect of cisplatin is its pronounced nephrotoxicity, which occurs at doses lower than those that damage other organs [3]. The underlying molecular mechanism of the nephrotoxicity induced by cisplatin remains unclear

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Effect of oral methionine on tissue lipid peroxidation and antioxidants in alloxan-induced diabetic rats

Cited by 71 publications

References 25 publications

Effect ofGaruga pinnata. Roxb Aqueous Bark Extract on Tissue Antioxidant Activity in Streptozotocin-Nicotinamide–Induced Type II Diabetic Rats

Effect ofGaruga pinnata. Roxb Aqueous Bark Extract on Tissue Antioxidant Activity in Streptozotocin-Nicotinamide–Induced Type II Diabetic Rats

Antihyperglycemic and antilipidperoxidative effects ofTephrosia purpurea seed extract in streptozotocin induced diabetic rats

Protective Role of Vitamin E and Acetazolamide in Cisplatin-Induced Changes in Lipid Peroxidation and Antioxidant Enzyme Levels in Albino Rats.

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