Antihyperglycemic and antilipidperoxidative effects ofTephrosia purpurea seed extract in streptozotocin induced diabetic rats

Pavana, P; Sethupathy, S; Manoharan, Shanmugam

doi:10.1007/bf02912886

Cited by 44 publications

(36 citation statements)

References 28 publications

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“…Hyperglycemia was confirmed by elevated glucose levels in plasma, determined at 72 h and then on day 7 after injection. The threshold value of fasting plasma glucose to diagnose diabetes was taken as >126 mg/dL.…”

Section: Induction Of Diabetesmentioning

confidence: 99%

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Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

Ramesh

Rasineni

Sreenivasa

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Induction Of Diabetesmentioning

confidence: 99%

“…Many herbal extracts or derivatives with high antioxidant activity are useful for treatment of diabetes and other metabolic syndrome [5] . Over production of ROS and insufficient antioxidant defense mechanism were well documented in diabetic patients as well as in experimental diabetes mellitus [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

Ramesh

Rasineni

Sreenivasa

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…There is evidence of pharmacological activity of extracts obtained from plants of Tephosia genus including toxic and lavicidal effects (Arriaga et al, 2009a;Lapointe et al, 2003), antifungal (Vijayan et al, 2008), anti-Helicobacter pylori (Chinniah et al, 2009), wound healing potential (Lodhi et al, 2006), hepatoprotective against thioacetamide-induced hepatotoxicity (Khatri et al, 2009), antihyperglycemic and antihyperlipidemic in streptozotocin induced diabetic rats (Pavana et al, 2007), alleviates phorbol ester-induced tumor promotion response in murine skin , ameliorates N-diethylnitrosamine and potassium bromate-mediated renal oxidative stress and toxicity in rats (Khan et al, 2001), reduction in the severity of lithium-pilocarpine induced status epilepticus (Asuntha et al, 2010) and a flavonoidal fraction of T. purpurea inhibits sheep red blood cells-induced delayed-type hypersensitivity reactions (Damre et al, 2003). Thus, there are some pharmacological studies on the Tephosia genus activities.…”

Section: Discussionmentioning

confidence: 99%

Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production

Martínez

Zarpelon

Zimermann

et al. 2012

Rev. bras. farmacogn.

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Abstract:Tephrosia toxicaria (Sw.) Pers., which is currently known as T. sinapou (Buc'hoz) A. Chev., Fabaceae, is a source of compounds such as fl avonoids, however, few studies addressed the anti-infl ammatory and antioxidant effects of T. sinapou. Therefore, we evaluated the antioxidant mechanisms of the T. sinapou ethyl acetate extract in vitro, and whether the extract affects leukocyte recruitment in four models of infl ammation and the involvement of nitric oxide and cytokines in its mechanism. In vitro, it was observed that the extract presented hydrogen donating ability to 2,2-diphenyl-1-picryl-hydrazyl radical (DPPH • ), 2,2'-azino-di-(3-ethylbenzthiazoline-6-sulphonic acid) radical (ABTS + ), and also effi ciently inhibited iron-dependent and independent lipid peroxidation and iron chelation assays. In vivo, it inhibited the recruitment of total leukocytes and neutrophil induced by carrageenin, zymosan, glycogen and lipopolysaccharide in the peritoneal cavity of mice. Two mechanisms were detected: 1) T. sinapou effect on leukocyte recruitment depends on nitric oxide since was dose-dependently inhibited by treatment with L-NAME (nitric oxide synthase inhibitor), and 2) the extract also inhibited the production of crucial cytokines for the leukocyte recruitment; tumor necrosis factor α and interleukin-1β. Concluding, T. sinapou ethyl acetate extract reduces oxidative stress in vitro, and infl ammatory leukocyte recruitment by a mechanism related to inhibition of cytokine production, and in a nitric oxide dependent manner in vivo.

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“…GSH is one of the most abundant non-enzymatic antioxidant biomolecules present in tissues which can alter the diabetic effects via scavenging free radicals or preventing their conversion to toxic products or provision of a substrate for glutathione peroxidase and glutathione S-transferase [52][53][54]. [55].…”

Section: The Hepatic Ameliorative Effect Of I Tricolor and S Tomentosamentioning

confidence: 99%

Statistical Data Analysis Which Result From the Bio-Diagnosis and Bio-Treatment of Injured Rats With the Hyperlipidemia and Hyperglycemia Diseases

Abduallah¹,

Abd‐Alla²,

Ali³

et al. 2016

Asian J Pharm Clin Res

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Objective: This study in bioinformatics aims to investigate the potential effect of Ipomoea tricolor and Sophora tomentosa on liver function enzymes activity, serum lipid profile, oxidative stress biomarkers, and on blood glucose in high fat diet-induced hypercholesterolemia (HC) and STZ-induced hyperglycemia (HG) in rats.Methods: Blood glucose level, liver function enzymes, alanine aminotransferases and aspartate aminotransferases, alkaline phosphatase, and lactate dehydrogenase (LDH) were determined. Besides, lipid profile including total cholesterol (TC), triacylglycerol (TG), total lipid, and high-density lipoprotein-cholesterol was investigated. Moreover, oxidative stress biomarkers, lipid peroxide, and nitric oxide as well as non-enzymatic antioxidant, glutathione (GSH) were also examined in different therapeutic groups.Results: A significant increase in blood glucose level, liver function enzyme activities, LDH, lipid profile and oxidative stress markers, while significant decrease in LDH-C and GSH level in HC-HG induced rats compared to control one. A marked amelioration in all biochemical parameters under investigation on treatment of HC-HG rats with I. tricolor and S. tomentosa with different fluctuating percentages of improvement. Histopathological examination of liver and pancreas was also performed and declared HC-HG showed congestion in portal vessels and sinusoids with mild centrilobular hepatocyte degeneration, marked hepatocyte ballooning and hydropic degeneration, while HC-HG treated rats with I. tricolor and S. tomentosa showed normal lobular hepatic architecture with mild sinusoidal dilatation and congestion. On the other hand, a histological organization of pancreas of HC-HG rats showing disarrangement changes in pancreatic blood vessels and interlobular duct as well as disordered in acini. The treatment of HC-HG rats with I. tricolor and S. tomentosa showed enhancement in Langerhans cells and restore of most pancreatic tissue in comparison with standard drugs. Conclusion:The statistical results showed that each extract ameliorated high blood glucose level liver injury, HC and oxidative stress indicating relieving of oxidative damage associated with the complexity of HG and HC. These results demonstrated that these two plants extracts may be a candidate intelligent antioxidant, hypolipidemic, hypoglycemic, and hepatoprotective nutraceuticals which need further clinical investigation to be applied effectively to reduce perturbation in HC associated diabetes.

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Antihyperglycemic and antilipidperoxidative effects ofTephrosia purpurea seed extract in streptozotocin induced diabetic rats

Abstract: ABSTRACT

Cited by 44 publications

References 28 publications

Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

Effect of Commiphora mukul gum resin on hepatic marker enzymes, lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production

Statistical Data Analysis Which Result From the Bio-Diagnosis and Bio-Treatment of Injured Rats With the Hyperlipidemia and Hyperglycemia Diseases

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