Effect of Oral Glutamine Supplementation on Gut Permeability and Endotoxemia in Patients With Severe Acute Pancreatitis

Singh, Namrata; Mishra, Sushil Kumar; Sachdev, Vikas; Sharma, Hunny; Upadhyay, Ashish Datt; Arora, Indu; Saraya, Anoop

doi:10.1097/mpa.0000000000000124

Cited by 17 publications

(16 citation statements)

References 28 publications

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“…In contrast, patients with AP who received EN did not require glutamine supplementation (65). Finally, oral glutamine supplementation did not seem to confer any significant effect on gut permeability and endotoxemia in severe AP (67). Characteristics of clinical studies on glutamine supplementation included in this review have been summarized in Table 3.…”

Section: Nutritional Supplementsmentioning

confidence: 92%

Recent Advances on Nutrition in Treatment of Acute Pancreatitis

Pan

Shamoon

et al. 2017

Front. Immunol.

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Acute pancreatitis (AP) is a common abdominal acute inflammatory disorder and the leading cause of hospital admission for gastrointestinal disorders in many countries. Clinical manifestations of AP vary from self-limiting local inflammation to devastating systemic pathological conditions causing significant morbidity and mortality. To date, despite extensive efforts in translating promising experimental therapeutic targets in clinical trials, disease-specific effective remedy remains obscure, and supportive care has still been the primary treatment for this disease. Emerging evidence, in light of the current state of pathophysiology of AP, has highlighted that strategic initiation of nutrition with appropriate nutrient supplementation are key to limit local inflammation and to prevent or manage AP-associated complications. The current review focuses on recent advances on nutritional interventions including enteral versus parenteral nutrition strategies, and nutritional supplements such as probiotics, glutamine, omega-3 fatty acids, and vitamins in clinical AP, hoping to advance current knowledge and practice related to nutrition and nutritional supplements in clinical management of AP.

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Section: Nutritional Supplementsmentioning

confidence: 92%

Recent Advances on Nutrition in Treatment of Acute Pancreatitis

Pan

Shamoon

et al. 2017

Front. Immunol.

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“…‐ 10 However, other studies note that although Gln has the above‐mentioned positive tendencies, there is no significant difference compared with the control group; according to the current evidence level, we are still not sure of the exact curative effect of Gln in the treatment of SAP 11 . ‐ 13 Furthermore, the 2013 guideline “Diagnosis and Treatment for Acute Pancreatitis of China” suggested Gln‐enriched nutrition support therapy for patients with SAP, 14 but there was no corresponding provision in the American guideline 15 . Thus, the roles of Gln for SAP comprehensive treatment measures still need further high‐quality RCTs for verification.…”

mentioning

confidence: 94%

Efficacy of Glutamine‐Enriched Nutrition Support for Patients With Severe Acute Pancreatitis

Yong

Liu

et al. 2015

J Parenter Enteral Nutr

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“…For other studied oral refeeding materials, like pancreatic enzymes, glutamine, or placebo supplementation,[1920] large-scale studies are required to obtain more reliable results for clinical application.…”

Section: Discussionmentioning

confidence: 99%