Effect of oral contraceptive agents on nutrients: I. Minerals

Abstract

The epidemiological aspects of oral contraceptive agents on nutrient metabolism were studied in a large population of women. Incidence of clinical abnormalities, related to malnutrition, were more frequently observed in the lower (B) as compared to the higher (A) socioeconomic groups. In the A groups some clinical signs were more common in the nonsupplemented groups of subjects. In general, the intake of oral contraceptive agent subjects for calories, protein, calcium, magnesium, iron, copper and zinc did not differ from the controls. The intake of the above nutrients in group A subjects were higher than those of group B except for calories. The subjects who took supplements had higher intakes of calcium, iron, magnesium and copper. No effect of oral contraceptive agents was seen on hemoglobin, hematocrit and erythrocyte count. Serum iron was increased due to "Norinyl." Total iron binding capacity was increased as a result of oral contraceptive agent administration. Total iron binding capacity values were higher in group B as compared to group A and in the nonsupplemented as compared to the supplemented groups. Plasma copper was increased and plasma zinc was decreased as a result of oral contraceptive agent administration. An increase in erythrocyte zinc was observed due to "Norinyl." No effect of oral contraceptive agents on plasma calcium, magnesium and erythrocyte magnesium was observed. Although no effect of oral contraceptive agents on plasma total protein was found, serum albumin was decreased.

Status of Serum Calcium and Magnesium in Women Taking Oral Contraceptive

“…In our study there was no significant difference of serum calcium level in oral contraceptive user women when compared with non oral contraceptive user women which is in agreement with several other studies 18,19 .…”

Effect of Estrogen (Estinyl) on Ascorbic Acid Metabolism

“…1, No. 1,1986 pigs following the oral administration of ascorbic acid, we found the rate to be decreased, when estrogen was simultaneously administered (Fig. 1).…”

“…An appreciable amount of scientific attention has been focused on the quantitative changes produced in the nutritional-metabolic profile of oral contraceptive users [1,2]. Much attention has been directed toward the study of changes in biochemical processes that may affect the nutritional status of the individual, with particular reference to ascorbic acid.…”

Variations in Serum Concentrations of Lead, Copper, Zinc and Selenium in Women Practicing Different Contraceptive Methods at Abia State University Teaching Hospital, Aba, Nigeria

“…However, the serum level of copper (mg/dl) in women on implant and IUCD were significantly higher when compared with women on COCP and significantly lower in women on implant when compared with women on IUCD. Studies have reported that contraceptives are associated with increased serum copper level [20][21][22]. Pincemail and colleagues reported that a woman having a plastic T-shaped frame wrapped with cooper band presented a plasma copper value that remained within the normal range [23].…”