Effect of Estrogen (Estinyl) on Ascorbic Acid Metabolism

N-Nitrosodiethylamine Induced Changes in Levels, Metabolism, and Urinary Excretion of Ascorbic Acid in Guinea Pigs.

“…After an overnight fasting, 14C-AA (0.2 1u Ci/ 100 g body weight) was administered orally by intubation to all the animals. Soon after, radiorespirometric studies were conducted for 200 min by a modified method of Basu et al [11]. In short, individual animals were kept in an airtight perspex chamber.…”

“…Human studies have revealed that plasma ascorbate reserves are depleted in a number of conditions such as inflammation [1,2], surgical trauma [3,4], myocardial infarction [5], smoking [6], use of oral contraceptives [7][8][9] , and thermal burns [10]. Similarly, estrogen administration to female guinea pigs reduced the plasma ascorbate levels [11]. It is likely that there may be a large number of other conditions that might affect the body ascorbate status.…”

The Contribution of Plasma and Brain Vitamin C on Age and Gender-Related Cognitive Differences: A Mini-Review of the Literature

“…One study using female guinea pigs has shown estinyl and progestogen containing contraceptives to reduce circulating ascorbate concentrations (Basu et al, 1974 ) and estinyl alone to reduce plasma and liver ascorbate concentrations (Basu et al, 1986 ). The authors hypothesized that these results may be due to these hormones increasing ascorbic acid oxidation and impairing its gastrointestinal absorption.…”