Effect of oral administration of water-soluble extract from citrus peel (Citrus unshiu) on suppressing alcohol-induced fatty liver in rats

Park, Ho-Young; Park, Yongkon; Lee, Young-Suk; Noh, Sang K.; Sung, Eon‐Gi; Choi, In-Wook

doi:10.1016/j.foodchem.2011.07.081

Cited by 23 publications

(14 citation statements)

References 28 publications

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“…Sildenafil, acting via nitric oxide (NO)dependent mechanism, prevented indomethacin-induced gastropathy (gastric mucosa damage) possibly through a reduction of leukocyte adhesion and maintenance of gastric blood flow (Aydinli et al, 2007 andSantos et al, 2005). Liver-related diseases are still among the leading causes of morbidity and mortality all over the world (Park et al, 2012). Since oxidative stress is one of the main causes of radiation-induced liver injury (Verma et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Gastro Hepatic Protective Effects of Sildenafil in γ-Irradiated Rats

2013

Egypt. J. Rad.Sci.

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Section: Discussionmentioning

confidence: 99%

Gastro Hepatic Protective Effects of Sildenafil in γ-Irradiated Rats

2013

Egypt. J. Rad.Sci.

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“…These findings were in line with previous studies. Park et al (2012) reported a significant reduction in total cholesterol of rats fed high doses (576 ml/day) of Citrus unshiu peel extract as compared to low doses. Mollace et al (2011) also reported a significant increase in HDL-c while total cholesterol, LDL-c, and triglyceride decreased in rats fed citrus flavonoid-rich extract.…”

Section: Anti-hyperlipidemic Potential Of Citrus Maxima Peel Extractmentioning

confidence: 97%

Anti-diabetic, anti-hyperlipidemic and hepatoprotective potential of shaddock (Citrus maxima) peel extract

Ani

Ochu

2020

Acta Sci Pol Technol Aliment

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Background. Diabetes is a serious public health problem which poses serious socioeconomic burden at the national and global level. Most synthetic agents for treating diabetes are expensive and not devoid of adverse effect hence, the need for continuous effort in the search for affordable and natural effective treatment of diabetes. This study investigated the anti-diabetic, anti-hyperlipidemic, and hepatoprotective effects of Citrus maxima peel extract on alloxan-induced diabetic rats. Materials and methods. Twenty-eight adult male Wistar rats were categorized into four groups of seven rats with similar body weights. Diabetes was induced using alloxan and baseline data obtained. Rats in groups A, B, and C were administered with 200 mg, 400 mg, and 600 mg of Citrus maxima peel extract per kg body weight/day, respectively for 14 days. Group D (control) received 200 mg of plain water per kg body weight/ day. Biochemical analyses of blood glucose, lipid profile, and liver enzyme activities were performed after the feeding trial. Data were analyzed using SPSS, version 21. Results. Citrus maxima peel extract significantly decreased (p < 0.05) the blood glucose level by 70.17%. The extract (600 mg) resulted in a percentage increase in high-density lipoprotein cholesterol (4.43%) and decrease in total cholesterol (30.86%), triglyceride (10.58%) and low-density lipoprotein cholesterol (10.20%). Liver enzyme activities of the control groups significantly increased while the treated groups showed no significant change. Conclusion. Citrus maxima peel extract has proven to be effective in diabetes management. However, use of standardized extract and proper laboratory tests are necessary.

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“…Frozen sections of liver (5-6 μm) were cut using a microtome, and then washed with ethanol and water. The frozen section was counterstained with hematoxylin for 45 s. An image was then captured under a light microscope at 200× magnification (Park et al, 2012).…”

Section: Liver Histopathological Studiesmentioning

confidence: 99%

Antialcoholic liver activity of whey fermented by Lactobacillus casei isolated from koumiss

Zhao

Pan

et al. 2014

Journal of Dairy Science

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Whey fermented liquid (WFL) was studied for its hepatoprotective effects by using chronic alcohol-induced mice. Whey fermented liquid, prepared by inoculating whey with 4% (vol/vol) Lactobacillus casei and then incubating at 41°C for 8h, was used to orally treat alcohol-induced mice at 3 dosages for 5 wk. Ethanol consumption significantly reduced the activity of superoxide dismutase and glutathione peroxidase, while lowering glutathione content and increasing levels of aspartate aminotransferase, alanine aminotransferase, total triglyceride, malondialdehyde, and cytochrome P450 2E1. Treatment with WFL significantly attenuated the increased levels of alanine aminotransferase, aspartate aminotransferase, triglyceride, and cytochrome P450 2E1, while decreasing superoxide dismutase, glutathione peroxidase, malondialdehyde, and glutathione levels. Pathological changes in the livers of mice who had ingested alcohol were improved by the administration of WFL. These results suggest that WFL may exert a protective effect against alcoholic liver disease by increasing antioxidant activity, which supports the use of WFL as an antialcoholic liver disease treatment.

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Effect of oral administration of water-soluble extract from citrus peel (Citrus unshiu) on suppressing alcohol-induced fatty liver in rats

Cited by 23 publications

References 28 publications

Gastro Hepatic Protective Effects of Sildenafil in γ-Irradiated Rats

Gastro Hepatic Protective Effects of Sildenafil in γ-Irradiated Rats

Anti-diabetic, anti-hyperlipidemic and hepatoprotective potential of shaddock (Citrus maxima) peel extract

Antialcoholic liver activity of whey fermented by Lactobacillus casei isolated from koumiss

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