Effect of One- or Two-Week Triple Therapy with Omeprazole, Amoxicillin, and Clarithromycin on Eradication of <i>Helicobacter pylori</i> Infection in Children

Choi, In Kyoung; Lee, Seung Yun; Chung, Ki Sup

doi:10.5223/kjpgn.2002.5.1.19

Cited by 7 publications

(9 citation statements)

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“…Moreover, our results revealed that the effectiveness of the triple therapy has decreased over time, corresponding with the findings of several previous studies [4]. According to other studies that included Korean children, the rate of H. pylori eradication with the 2-week triple therapy comprising PPI, amoxicillin, and clarithromycin was 84.6% in 1998-2000 and 74% in 1999-2004 [10,11]. The European pediatric treatment registry recently reported the results from the use of 27 different regimens in 518 children, where the eradication rate by the standard 2-week triple therapy, i.e., the same regimen as ours, was 60.5% [12].…”

Section: Discussionsupporting

confidence: 89%

Efficacy of Proton Pump Inhibitor-based Triple Therapy and Bismuth-based Quadruple Therapy forHelicobacter pyloriEradication in Korean Children

Hong

Yang

2012

Pediatr Gastroenterol Hepatol Nutr

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PurposeThe aim of this study was to assess and compare the efficacies of proton pump inhibitor-based triple therapy and bismuth-based quadruple therapy as first-line treatments for Helicobacter pylori eradication in Korean children.MethodsWe retrospectively reviewed the data of children who had been diagnosed with H. pylori infection at the Seoul National University Bundang Hospital from March 2004 to August 2012. The patients were randomly assigned to receive either triple therapy consisting of omeprazole, amoxicillin, and clarithromycin for 2 weeks (OAC group) or quadruple therapy comprising omeprazole, amoxicillin, metronidazole, and bismuth salts for 1 week (OAMB group). The patients were evaluated for eradication of H. pylori infection at 4 weeks after the completion of the treatment.ResultsOf the 129 children enrolled in this study, 118 (91.5%) were included in the final analysis. The eradication rates in OAC and OAMB groups were 67.7% (42/62) and 83.9% (47/56), respectively, which were significantly different between the 2 treatment groups (p=0.041). The eradication rates in the OAMB group during the periods 2004-2006, 2007-2009, and 2010-2012 were superior to those in the OAC group.ConclusionThis study indicated that the 1-week bismuth-based quadruple therapy, compared with the standard 2-week triple therapy, was significantly more successful in eradicating H. pylori infection in Korean children.

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Section: Discussionsupporting

confidence: 89%

Efficacy of Proton Pump Inhibitor-based Triple Therapy and Bismuth-based Quadruple Therapy forHelicobacter pyloriEradication in Korean Children

Hong

Yang

2012

Pediatr Gastroenterol Hepatol Nutr

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“…The rate of H. pylori infection is intimately connected to a country's socioeconomic level, race, and age, and is higher in developing countries than in developed countries. As the economic state worsens, the rate of infection rises, and as age increases, the frequency of infection also increases 21,22. Bahu et al15 reported that in children with H. pylori infection, the frequency of nodular gastritis and the density of H. pylori increase as they age.…”

Section: Discussionmentioning

confidence: 99%

Nodular Gastritis and Pathologic Findings in Children and Young Adults with Helicobacter pylori Infection

et al. 2007

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PurposeThe aim of this study was to investigate the pathologic characteristics of nodular gastritis in children and young adults infected with Helicobacter pylori (H. pylori).Materials and MethodsA total of 328 patients were enrolled in this study, and the diagnosis of H. pylori infection was done with gastroduodenal endoscopy concomitant with a CLO™ test and pathologic analysis of the biopsy specimens. Diagnoses of normal, superficial gastritis, nodular gastritis, and peptic ulcer disease were made from the gastroduodenal endoscopic findings. The density of H. pylori organisms in the gastric mucosa was rated as normal, mild, moderate, or marked. The pathologic findings of nodular gastritis were based on the histopathologic findings of inflammation, immune activity, glandular atrophy and intestinal metaplasia. Each of these findings was scored as either normal (0), mild (1), moderate (2), or marked (3) according to the updated Sydney system and using visual analog scales. The gastritis score was the sum of the four histopathologic scores.ResultsIn this study, nodular gastritis (50.6%) was most common, and mild density (51.5%) H. pylori infection was also common upon microscopic examination. Intestinal metaplasia occurred in 9 patients (2.7%).ConclusionLogistic regression revealed a significant increase in the incidence of nodular gastritis with gastritis score (p = 0.008), but not an association with sex, age, or H. pylori density. Gastritis score was the only significant factor influencing the occurrence of nodular gastritis. Intestinal metaplasia, which was originally thought to be a pre-malignant lesion, occurred in 2.7% of the patients with H. pylori infection.

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“…Other studies in South Korea have reported a decreasing tendency in the rate of H. pylori eradication by the administration of omeprazole with amoxicillin and clarithromycin, specifically a decrease from 81.0% between 1998 and 200037), to 74.0% between 1999 and 200038), and to 67.7% between 2004 and 201239). Moreover, it has been reported that the quadruple therapy showed a higher rate of H. pylori eradication than the triple therapy39).…”

Section: Treatment Of H Pylori Infections In Childrenmentioning

confidence: 95%

“…Four studies comparing the effectiveness of different treatment modalities for H. pylori infection in South Korean children all found that a bismuth-based triple therapy was more effective against H. pylori as the first-line of treatment than a PPI-based therapy ( Table 3 ) 36 , 37 , 38 , 39) . Other studies in South Korea have reported a decreasing tendency in the rate of H. pylori eradication by the administration of omeprazole with amoxicillin and clarithromycin, specifically a decrease from 81.0% between 1998 and 2000 37) , to 74.0% between 1999 and 2000 38) , and to 67.7% between 2004 and 2012 39) . Moreover, it has been reported that the quadruple therapy showed a higher rate of H. pylori eradication than the triple therapy 39) .…”

Section: Treatment Of H Pylori Infections In Chilmentioning

confidence: 99%

Antibiotics resistance ofHelicobacter pyloriand treatment modalities in children withH. pyloriinfection

et al. 2014

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Pediatric infection with Helicobacter pylori may occur early in childhood and persist lifelong. Global pediatric clinical studies have reported a decreasing tendency in the overall rate of H. pylori eradication. In pediatric patients with H. pylori infection, pediatric patients with peptic ulcer, and the first-degree relatives of patients with a history of gastric cancer, it is commonly recommended that H. pylori strains be eradicated. Antibiotic drug resistance to H. pylori, which has been reported to vary widely between geographic regions, is mainly associated with treatment failure in these patients. It is therefore imperative that the antibiotic resistance rates of H. pylori in children and adolescents be meticulously monitored across countries and throughout geographic regions. This paper particularly focuses on the antibiotic drug resistance of H. pylori and the thearpy of pediatric H. pylori infection cases.

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Effect of One- or Two-Week Triple Therapy with Omeprazole, Amoxicillin, and Clarithromycin on Eradication of Helicobacter pylori Infection in Children

Cited by 7 publications

References 0 publications

Efficacy of Proton Pump Inhibitor-based Triple Therapy and Bismuth-based Quadruple Therapy forHelicobacter pyloriEradication in Korean Children

Efficacy of Proton Pump Inhibitor-based Triple Therapy and Bismuth-based Quadruple Therapy forHelicobacter pyloriEradication in Korean Children

Nodular Gastritis and Pathologic Findings in Children and Young Adults with Helicobacter pylori Infection

Antibiotics resistance ofHelicobacter pyloriand treatment modalities in children withH. pyloriinfection

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