Effect of omeprazole on intraduodenal and intragastric pH in healthy volunteers

Gan, K. H.; Geus, W. P.; Heijerman, H.G.M.; Bakker, Willem H.; Lamers, C. B. H. W.

doi:10.1016/0300-2977(95)96957-j

Cited by 5 publications

(7 citation statements)

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“…With once-daily dosing, proton pump inhibitors inhibit only 70% of active pumps at steady state 40 41. For patients taking oral omeprazole 40 mg once daily, even doubling the dose might not keep the intragastric pH at ≥4.0 during the night time, because of diurnal rhythm 22 23 42 43. With a double-dose regimen, the dose given twice daily extends the mean residence time enabling them to inhibit restored pumps after initial proton pump inhibitor inactivation 44 45.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown limited effectiveness for 3-day proton pump inhibitor infusion followed by a standard oral, once-daily dose for control of rebleeding in patients with comorbidities 8 17 18. This lack of control might be due to incomplete suppression of gastric acid secretion for 24 h by the oral proton pump inhibitor when taken once daily during this critical post-haemorrhage period 22 23…”

Section: Introductionmentioning

confidence: 99%

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Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study

Cheng

Chang

et al. 2014

Gut

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study

Cheng

Chang

et al. 2014

Gut

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“…Up to 20% of a carbohydrate meal may reach the terminal ileum 76 77 and following ingestion of a mixed meal ileal lipid concentrations of up to about 10 mg/ml were measured. 57 78 79 There are fewer data on physiological malabsorption of proteins because it has been difficult to differentiate between dietary and endogenous proteins. A recent study using labeled egg protein suggests that about 6% of cooked and 35% of raw egg protein escape digestion and absorption in the small intestine in healthy humans.…”

Section: Initiation and Termination Of Digestive Enzyme Responsementioning

confidence: 99%

Human pancreatic exocrine response to nutrients in health and disease

Keller

2005

Gut

301

224

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“…However, probably because of diurnal rhythm, the intragastric pH in patients on oral omeprazole falls to a median pH of 3.03 during the night period from 22:00 to 06:00 [83] . Therefore, oral omeprazole 40 mg once daily does not suppress gastric acid secretion completely throughout the 24 h period 84] .…”

Section: Ppismentioning

confidence: 99%

Intravenous proton pump inhibitors for peptic ulcer bleeding: Clinical benefits and limits Hsiu-Chi Cheng, Bor-Shyang Sheu

Cheng

Sheu

2011

WJGE

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Peptic ulcer bleeding is a common disease and recurrent bleeding is an independent risk factor of mortality. Infusion with proton pump inhibitors (PPIs) prevents recurrent bleeding after successful endoscopic therapy. A gastric acidic environment of less than pH 5.4 alters coagulation function and activates pepsin to disaggregate platelet plugs. Gastric acid is secreted by H(+), K(+)-ATPase, naming the proton pump. This update review focuses on the mechanism and the role of PPIs in the clinical management of patients with peptic ulcer bleeding. An intravenous omeprazole bolus followed by high-dose continuous infusion for 72 h after successful endoscopic therapy can prevent the recurrent bleeding. In the Asian, however, the infusion dosage can possibly be diminished whilst preserving favorable control of the intragastric pH and thereby still decreasing rates of recurrent bleeding. Irrespective of the infusion dosage of PPIs, rates of recurrent bleeding remain high in patients with co-morbidities. Because recurrent peptic ulcer bleeding may be prolonged in those with co-morbidities, a low-dose infusion of IV PPIs for up to 7-day may result in better control of recurrent bleeding of peptic ulcers. Due to the inter-patient variability in CYP2C19 genotypes, the infusion form of new generation PPIs, such as esomeprazole, should be promising for the prevention of recurrent bleeding. This article offers a comprehensive review of clinical practice, highlighting the indication, the optimal dosage, the duration, and the potential limitation of PPIs infusion for peptic ulcer bleeding.

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Effect of omeprazole on intraduodenal and intragastric pH in healthy volunteers

Cited by 5 publications

References 0 publications

Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study

Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study

Human pancreatic exocrine response to nutrients in health and disease

Intravenous proton pump inhibitors for peptic ulcer bleeding: Clinical benefits and limits Hsiu-Chi Cheng, Bor-Shyang Sheu

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