Effect of omega-3 fatty acids supplementation during pregnancy on lung function in preschoolers: a clinical trial

Gutiérrez-Delgado, Rosa Inés; Villarreal, Albino Barraza; Escamilla-Núñez, Consuelo; Hernández‐Cadena, Leticia; García‐Feregrino, Raquel; Shackleton, Claire; Ramakrishnan, Usha; Sly, Peter D.; Romieu, Isabelle

doi:10.1080/02770903.2018.1452934

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…Pathophysiological changes were mainly due to increased Qs/Qt and imbalance of ventilation/blood flow ratio [ 37 ]. The application of omega-3 fatty acids not only can quickly reduce the inflammatory reaction of lung tissue, but also can transform LTB4, which aggravates inflammatory reaction, into LTB5 series, which is less active, thereby significantly reducing pulmonary edema, improving the pulmonary vascular permeability [ 38 – 40 ]. Besides, as specific immunonutrients, omega-3 fatty can regulate the activity of lipid mediators, cytokines, and endothelial cell, thereby regulating the excessive inflammatory response of the body under infection and trauma [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

The effects and safety of omega-3 fatty for acute lung injury: a systematic review and meta-analysis

Huang¹,

Zheng²,

Huang³

et al. 2020

World J Surg Onc

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Background: Several randomized controlled trials (RCTs) have compared the treatment of acute lung injury (ALI) with omega-3 fatty, yet the results remained inconsistent. Therefore, we attempted this meta-analysis to analyze the role of omega-3 fatty in the treatment of ALI patients. Methods: We searched PubMed databases from inception date to October 31, 2019, for RCTs that compared the treatment of ALI with or without omega-3 fatty. Two authors independently screened the studies and extracted data from the published articles. Summary mean differences (MD) with 95% confidence intervals (CI) were calculated for each outcome by fixed-or random-effects model. Results: Six RCTs with a total of 277 patients were identified, of whom 142 patients with omega-3 fatty acid treatment and 135 patients without omega-3 fatty treatment. Omega-3 fatty treatments significantly improve the PaO 2 (MD = 13.82, 95% CI 8.55-19.09), PaO 2 /FiO 2 (MD = 33.47, 95% CI 24.22-42.72), total protein (MD = 2.02, 95% CI 0.43-3.62) in ALI patients, and omega-3 fatty acid treatments reduced the duration of mechanical ventilation (MD = − 1.72, 95% CI − 2.84 to − 0.60) and intensive care unit stay (MD = − 1.29, 95% CI − 2.14 to − 0.43) in ALI patients. Conclusions: Omega-3 fatty can effectively improve the respiratory function and promote the recovery of ALI patients. Future studies focused on the long-term efficacy and safety of omega-3 fatty use for ALI are needed.

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Section: Discussionmentioning

confidence: 99%

The effects and safety of omega-3 fatty for acute lung injury: a systematic review and meta-analysis

Huang¹,

Zheng²,

Huang³

et al. 2020

World J Surg Onc

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“…In a Ghanaian longitudinal cohort, infants exposed to a less diverse nasopharyngeal microbiome had a higher small airway resistance compared to a more diverse microbiome at 4 years of age ( 67 ). Further, in a Mexican birth cohort study, prenatal omega 3 fatty acid supplementation in pregnancy did not influence preschool lung function at 36, 48 or 60 months ( 68 ).…”

Section: Resultsmentioning

confidence: 99%

Lung Function in Preschool Children in Low and Middle Income Countries: An Under-Represented Potential Tool to Strengthen Child Health

Chaya

Zar²,

Gray³

2022

Front. Pediatr.

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BackgroundThe burden of respiratory disease is high in low-middle income countries (LMIC). Pulmonary function tests are useful as an objective measure of lung health and to track progression. Spirometry is the commonest test, but its use is limited in preschool children. Other lung function methods have been developed but their use in LMIC has not been well described.AimTo review the use of preschool lung function testing in children in LMIC, with particular reference to feasibility and clinical applications.MethodsElectronic databases “PubMed”, “Scopus”,” Web of Science”, and “EBSCO host” were searched for publications in low and middle income countries on preschool lung function testing, including spirometry, fractional exhaled nitric oxide (FeNO), oscillometry, interrupter technique, tidal breathing and multiple breath washout (MBW), from 1 January 2011 to 31 January 2022. Papers in English were included and those including only children ≥6 years were excluded.ResultA total of 61 papers from LMIC in Asia, South America, Africa, Eurasia or the Middle East were included. Of these, 40 included spirometry, 7 FeNO, 15 oscillometry, 2 interrupter technique, and 2 tidal breathing. The papers covered test feasibility (19/61), clinical application (46/61) or epidemiological studies (13/61). Lung function testing was successful in preschool children from LMIC. Spirometry was the most technically demanding and success gradually increased with age.ConclusionPreschool lung function testing is under-represented in LMIC for the burden of respiratory disease. These tests have the potential to strengthen respiratory care in LMIC, however access needs to be improved.

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“…It has been reported that the application of omega-3 fatty acids rapidly reduced the inflammatory reaction of lung tissue, by transforming leukotriene B4, which aggravates inflammatory reaction, into leukotriene B5 series (less active), therefore reducing pulmonary edema and improving pulmonary vascular permeability 85 . Huang et al 86 concluded that omega-3 acids can improve respiratory function and respiratory status of acute lung injury (ALI) patients and suggested that omega-3 fatty acid could be a potential effective and safe strategy for ALI treatment.…”

Section: Discussionmentioning

confidence: 99%

The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity

Abosrea

Ezz

Mahmoud

et al. 2023

Sci Rep

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Many chemotherapeutic drugs cause adverse pulmonary reactions leading to severe pulmonary disease. Though methotrexate (MTX) is used for the treatment of cancer and other diseases, it is highly toxic with multiple adverse effects including pulmonary toxicity. Essential oils represent an open frontier for pharmaceutical sciences due to their wide range of pharmacological properties. Pumpkin seeds oil (PSO) was used to investigate its ability to alleviate methotrexate-induced lung toxicity in rats. Lung tissue from MTX-treated group revealed a decrease in malondialdehyde, glutathione, and nitric oxide accompanied by a marked inhibition in cholinesterase activity, and enhanced catalase activity, tumor necrosis factor-α, interleukin-6 and vascular endothelial growth factor levels. Analysis of PSO revealed that the oil was rich in hexadecanoic acid, decane methyl esters, squalene, polydecane, docosane, and other derivatives. Administration of PSO ameliorated the oxidant/antioxidant and proinflammatory changes induced by MTX in the lung tissue. Histological examinations confirmed the potency of PSO in reducing the histopathological alterations induced by MTX. Immunohistochemical analysis showed decreased nuclear factor-kappa B and caspase 3 expression after PSO. The present data indicated the protective efficiency of PSO against MTX-induced lung injury by decreasing oxidative damage, inflammation and apoptosis and could thus be recommended as an adjuvant therapy.

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Effect of omega-3 fatty acids supplementation during pregnancy on lung function in preschoolers: a clinical trial

Abstract: Prenatal DHA supplementation did not influence pulmonary function in this cohort of Mexican preschoolers.

Cited by 12 publications

References 29 publications

The effects and safety of omega-3 fatty for acute lung injury: a systematic review and meta-analysis

The effects and safety of omega-3 fatty for acute lung injury: a systematic review and meta-analysis

Lung Function in Preschool Children in Low and Middle Income Countries: An Under-Represented Potential Tool to Strengthen Child Health

The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity

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