Effect of olive oil supplementation on PAI-1 expression in old rats

Abstract

Background: Although Mediterranean diet has grown worldwide due to its link with lower cardiovascular disease rate and greater longevity, the effect of olive oil, which is the principal component of Mediterranean diet, on plasminogen activator inhibitor-1 (PAI-1) concentrations in aged rats is not clear. This study was performed on 28 aged male Wistar albino rats allocated into two groups (14 rats each): Olive oil-treated group and the control group.

Olive leaf extract attenuates adriamycin‐induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis

“…It was shown that olive oil intake reduced PAI-1 gene expression in aged Wistar rats (Nassef, Youssef, Louka, & Habib, 2013). In our study, ADR-induced fibronectin overexpression has been completely abolished after OLE without changing the level of TGF-β protein expression.…”

“…The level of angiotensin II is increased in SHR (Fan et al, 2014), thus we suggest that increased fibronectin level in the kidney of SHR with ADR‐induced FSGS could be at least in part mediated by RAS induction of PAI‐1, independently of TGF‐β. It was shown that olive oil intake reduced PAI‐1 gene expression in aged Wistar rats (Nassef, Youssef, Louka, & Habib, 2013). In our study, ADR‐induced fibronectin overexpression has been completely abolished after OLE without changing the level of TGF‐β protein expression.…”