Effect of oligoethylene glycol moieties in porous silicon surface functionalisation on protein adsorption and cell attachment

Monolayer functionalization of silicon micro and nanowires : towards solar-to-fuel and sensing devices

“…Antifouling is mostly achieved by monolayers that contain oligo(ethylene glycol) moieties. 129,[152][153][154][155] Sweetman et al studied the antifouling properties of Si-C-bound monolayers on porous silicon. 129 Thermal hydrosilylation was used to bind two alkenes, which were identical apart from a tri(ethylene glycol) group.…”

“…129,[152][153][154][155] Sweetman et al studied the antifouling properties of Si-C-bound monolayers on porous silicon. 129 Thermal hydrosilylation was used to bind two alkenes, which were identical apart from a tri(ethylene glycol) group. The oligo(ethylene glycol) group exhibited low-fouling properties towards bovine serum albumin (BSA) but not towards fibronectin (Figure 2.13, 2 "adsorbed BSA" or "adsorbed fibronectin").…”

“…138 The latter methods have led to the immobilization of DNA, [138][139][140][141][142] peptides, 143 biotin-avidin sequences, [144][145][146] antibodies, 147 or other proteins. 129,148,149 The desired application then determines the functionality to be used. For example, Qin et al created an alkyne-functionalized monolayer, protected with a trimethylgermanyl group, which could be reacted subsequently with azide-containing mannose molecules in order to capture E. coli bacteria.…”

“…Si-C linkages are perfectly suited for this purpose, as opposed to silanebased monolayers, for example, of which the Si-O bonds are susceptible to hydrolysis. 129 Porous silicon degrades in aqueous environments into nontoxic silicic acid within hours to months, depending on its porosity. 129 The degradation can be advantageous in the case of drug delivery applications, for example, but is undesired for longer term applications.…”

“…129 Porous silicon degrades in aqueous environments into nontoxic silicic acid within hours to months, depending on its porosity. 129 The degradation can be advantageous in the case of drug delivery applications, for example, but is undesired for longer term applications. Canham et al studied the use of oxide-free monolayers to stabilize porous silicon under in vivo conditions, in this case human blood plasma.…”