Effect of Occupational Exposures on Male Fertility: Literature Review

Sheiner, Einat K; Hammel, Rachel; Potashnik, G.; Carel, Refael

doi:10.2486/indhealth.41.55

Cited by 169 publications

(100 citation statements)

References 50 publications

(49 reference statements)

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“…In 1995 the US Institute of Medicine Committee stated that "the prevailing view is that exposure of the human male to chemicals and ionizing radiation is generally unrelated to the occurrence of developmental endpoints such as miscarriage, birth defects, growth retardation and Table 1. Chemical and physical exposures that have been associated with reduced semen quality or impaired male fertility (for systematic reviews, see [15][16][17][18][19][20][21][22][23][24][25][26] npg cancer" [56]. The question is, however, whether lack of convincing examples of male mediated developmental toxicity in humans is due to the non-existence of this phenomenon due to huge methodological challenges in demonstrating effects.…”

Section: Male Mediated Development Toxicitymentioning

confidence: 99%

“…Although the sitting position may cause increase of scrotal temperature, this increase seems not strong enough to disrupt spermatogenesis that may recover during other parts of the day [13,14]. Research during past 25 years has identified a large number of chemicals and occupational exposures that may impair male fertility (Table 1) [15][16][17][18][19][20][21][22][23][24][25][26]. It should, however, be acknowledged that epidemiological studies of male fertility and semen quality are beset with a number of pitfalls and methodological limitations crude exposure assessment, low participation rates, inadequate study size and lacking quality assurance of the semen analysis [27,28].…”

Section: Occupational Hazardsmentioning

confidence: 99%

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Male reproductive organs are at risk from environmental hazards

Bonde¹

2009

Asian J Androl

106

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Male reproductive disorders that are of interest from an environmental point of view include sexual dysfunction, infertility, cryptorchidism, hypospadias and testicular cancer. Several reports suggest declining sperm counts and increase of these reproductive disorders in some areas during some time periods past 50 years. Except for testicular cancer this evidence is circumstantial and needs cautious interpretation. However, the male germ line is one of the most sensitive tissues to the damaging effects of ionizing radiation, radiant heat and a number of known toxicants. So far occupational hazards are the best documented risk factors for impaired male reproductive function and include physical exposures (radiant heat, ionizing radiation, high frequency electromagnetic radiation), chemical exposures (some solvents as carbon disulfide and ethylene glycol ethers, some pesticides as dibromochloropropane, ethylendibromide and DDT/DDE, some heavy metals as inorganic lead and mercury) and work processes such as metal welding. Improved working conditions in affluent countries have dramatically decreased known hazardous workplace exposures, but millions of workers in less affluent countries are at risk from reproductive toxicants. New data show that environmental low-level exposure to biopersistent pollutants in the diet may pose a risk to people in all parts of the world. For other toxicants the evidence is only suggestive and further evaluation is needed before conclusions can be drawn. Whether compounds as phthalates, bisphenol A and boron that are present in a large number of industrial and consumer products entails a risk remains to be established. The same applies to psychosocial stressors and use of mobile phones. Finally, there are data indicating a particular vulnerability of the fetal testis to toxicants-for instance maternal tobacco smoking. Time has come where male reproductive toxicity should be addressed form entirely new angles including exposures very early in life.

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Section: Male Mediated Development Toxicitymentioning

confidence: 99%

Section: Occupational Hazardsmentioning

confidence: 99%

Male reproductive organs are at risk from environmental hazards

Bonde¹

2009

Asian J Androl

106

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“…Occupational activities involving exposure to specific chemicals or expositions to toxicants may impair male reproductive health and cause infertility in humans [27,37,[42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58].…”

Section: Introductionmentioning

confidence: 99%

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Ten¹,

Mendiola²,

Torres-Cantero³

et al. 2008

TORSJ

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Human semen quality may be declining due to environmental pollutants, occupational exposures or changes in lifestyle. Nonetheless, we still know little about the impact of those factors on male fertility. Some heavy metals, volatile organic compounds or xenoestrogens may compromise reproductive male function. This process could take place along the human life cycle and not only in certain stages of development. We review the main factors that affect human male fertility and their possible influence in current human reproduction.

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“…Many jobs that require heavy daily computer use have been found to be stressful (Carajon, 1993;Mocci et al, 2001) and stress is a risk factor of infertility (Sheiner et al, 2003). Also, prolonged sitting in front of VDT may affect semen quality through increasing temperature of the testes (De Fleurian et al, 2009).…”

Section: Disccusionmentioning

confidence: 99%

Occupational Exposures and Male Infertility, a Case-Control Study

Mansour

et al. 2010

Egypt. J. Occup. Med.

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Abstract:Objectives: this study was carried out to examine the association between male infertility and certain occupational exposures. Methods: a case-control study was carried out from 2008 to 2009; on 255 infertile men and 267 fertile men controls. Occupational exposure to certain chemical, physical and psychological work-place hazards were assessed by self-report questionnaire. General and andrology medical examination were done for all participants, however semen analysis was done only for the infertile men cases, because the fertile men controls refused to give semen samples. Results: after adjustment of confounders, the results revealed that the following occupational exposure factors significantly increased the risk of male infertility: solvents and painting materials(OR: 3.88, 95% CI: 1.50-10.03), lead (OR: 5.43, 95% CI: 1.28-23.13), VDTs and computers (OR: 8.01, 95% CI: 4.03-15.87), shift work (OR: 3.60, 95% CI: 1.12-11.57) and workrelated stress (Fairly present: OR 3.11, 95% CI: 1.85-5.24; Often present: OR: 3.76, 95% CI: 1.96-7.52) Conclusion: although the limitations of this study, it supports other studies that ring the bell to minimize the exposure to the work-place hazards that may affect the fertility of men workers.

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Effect of Occupational Exposures on Male Fertility: Literature Review

Cited by 169 publications

References 50 publications

Male reproductive organs are at risk from environmental hazards

Male reproductive organs are at risk from environmental hazards

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Occupational Exposures and Male Infertility, a Case-Control Study

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