Effect of Occlusive Dressings on the Stratum Corneum Water Holding Capacity

Berardesca, Enzo; Vignoli, G. P.; Fideli, D.; Maibach, Howard I.

doi:10.1097/00000441-199207000-00007

Cited by 29 publications

(24 citation statements)

References 12 publications

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“…The hydration of the stratum cornea was indeed increased following application of the cooled hydrogel pads. This finding is in accordance with previous findings [3, 15,18,19,20]. Therefore, the cooling effect of the hydrogel pad at the level of the stratum corneum is opposite to that expected for regular cryogenic spray [21].…”

Section: Discussionsupporting

confidence: 93%

Dew Point Effect of Cooled Hydrogel Pads on Human Stratum Corneum Biosurface

2007

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Background: Cooled hydrogel pads are used to prevent overheating effects of laser therapy. They do not induce cold injuries to the skin, but their more subtle physiological effects have not been thoroughly studied. Purpose: To describe the changes in transepidermal water loss and electrometric properties of the skin surface following application of cooled hydrogel pads. Measurements were performed on normal forearm skin of 27 healthy volunteers and on freshly excised skin from abdominoplasty. Methods: LaserAid® hydrogel pads cooled to 4°C were placed for 15 min on the forearm skin. Measurements of transepidermal water loss (TEWL) and electrometric properties (Corneometer®, Nova DPM 900®) were performed before application and after removal of the cooled pads. Results: A consistent increase in corneometer units, dermal phase meter (DPM) values and TEWL were recorded at removal of the cooled hydrogel pads. Both the in vivo and in vitro assessments brought similar information. Discussion: The similar changes disclosed in vitro and in vivo suggest that a common physical process is operating in these conditions. The observed phenomenon is opposite to the predicted events given by the Arrhenius law probably because of the combination of cooling and occlusion by the pads. A dew point effect (air temperature at which relative humidity is maximal) is likely involved in the moisture content of the stratum corneum. Thus, the biological impact of using cooling hydrogel pads during laser therapy is different from the effect of a cryogenic spray cooling procedure. The better preservation of the water balance in the stratum corneum by the cooled hydrogel pads could have a beneficial esthetic effect on laser treated areas.

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Section: Discussionsupporting

confidence: 93%

Dew Point Effect of Cooled Hydrogel Pads on Human Stratum Corneum Biosurface

2007

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“…The exact mode of action of a HCD is still unknown. It is hypothesized that the impaired barrier function of the psoriatic skin is repaired [6, 21]. It is also speculated that the continuous contact of the therapeutic drug might lead to more absorption and a higher efficacy [22].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Calcipotriol Ointment Applied under Hydrocolloid Occlusion in Psoriasis

et al. 2000

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Background: Hydrocolloid (HCD) dressings enhance the efficacy of topical corticosteroids. Objective: We wanted to evaluate the effect of calcipotriol ointment under an HCD dressing in the treatment of psoriatic plaques. Methods: In 9 psoriatic patients, we cleared one plaque using this approach and took biopsies at start, clearance and relapse. Clinical and immunohistochemical validation was assessed. Results: After an average treatment of 3.6 weeks, each lesion had cleared (apart from some residual erythema). The average remission period was 8 weeks. During this treatment, the number of cycling epidermal cells (Ki-67-positive nuclei) and the expression of keratin 14 and keratin 16 had decreased substantially. In biopsies taken from the skin immediately adjacent to the relapsing lesion, these markers remained reduced which indicated the prolonged effect of calcipotriol on epidermal differentiation. Conclusion: It is speculated that combination therapy of calcipotriol with treatments with a different mode of action such as photo(chemo)therapy, corticosteroids and cyclosporine might be worthwhile.

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“…The harmful effect of occlusion is influenced by age [9] and the type of the occlusive material [10]. One group showed delayed barrier repair mechanisms under occlusion in hairless mice [11][12][13] and humans [14].…”

Section: Discussionmentioning

confidence: 99%

Effects of Prolonged Occlusion on Stratum corneum Barrier Function and Water Holding Capacity<sup>1</sup>

Fluhr

Lazzerini

Distante

et al. 1999

Skin Pharmacol Physiol

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Purpose of the Study: We aimed to evaluate whether prolonged occlusion can induce stratum corneum barrier damage, alterations in stratum corneum hydration or water-holding capacity (WHC) lasting longer than the occlusion time. Materials and Methods: 12 subjects were occluded on the forearm for 24, 48, 72 and 96 h. Two hours after occlusion removal, transepidermal water loss (TEWL) and skin hydration were measured and a sorption-desorption test performed. Results: TEWL showed an increase reaching a plateau on day 2. Hydration and WHC did not show significant changes. Hygroscopicity showed the highest level on day 1, decreasing during the following days. A highly significant correlation between capacitance values and the WHC could be detected (p < 0.0001, r = 0.8206). No correlation could be detected between hygroscopicity and TEWL. Conclusions: Prolonged occlusion induces barrier damage without skin dryness. Occlusion also induces an increased hygroscopicity. A correlation between these two findings could not be proven.

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Effect of Occlusive Dressings on the Stratum Corneum Water Holding Capacity

Cited by 29 publications

References 12 publications

Dew Point Effect of Cooled Hydrogel Pads on Human Stratum Corneum Biosurface

Dew Point Effect of Cooled Hydrogel Pads on Human Stratum Corneum Biosurface

Efficacy of Calcipotriol Ointment Applied under Hydrocolloid Occlusion in Psoriasis

Effects of Prolonged Occlusion on Stratum corneum Barrier Function and Water Holding Capacity<sup>1</sup>

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