Effect of Obstructive Jaundice on Polyarthritis in Rats.

Abstract

pigs can be niairitairied for at least 6 weeks on a iiornial diet if salt drinkitig fluid is offered. .Desoxycorticosterone acetate subcutaneously administered in daily doses of 0.5 to 1.0 mg produces normal growth in adrenalectomized guinea pigs. Even though adreiialectomized guinea pigs had been maintained for over 5 months by salt and hormone therapy, they died on an average of 4.6 days after discontinuing this therapy.

The Experimental Production of Arthritis: A Review

“…Streptomycin and myocrisin were shown to be effective means of treating experimental P.P.L.O. arthritis (Powell, Jamieson, and Rice, 1946) following the earlier work of Findlay and others (1939), and of Sabin (1940), on the value of gold and of sulphonamides, and that of Snow and Hines (1941) on the influence of obstructive jaundice (Engerman and Meyer, 1959). Tripi and Kuzell (1947) confirmed the value of gold, but Gardner, Fairley, and Kuzell (1949) adopted the reciprocal approach and showed that animals treated with B.A.L.…”

Anti-Inflammatory Effect of Obstructive Jaundice in Rats

“…Reports followed of remissions attending jaundice induced by the injection of bile salts and bilirubin (Thompson and Wyatt, 1938), by inoculation with infectious jaundice (Gardner, Stewart, and Mac-Callum, 1945), and by lactophenin (Hanssen, 1942), in addition to the many remissions attributed to cinchophen toxic hepatitis. In rats also, jaundice caused by the ligation of the bile duct inhibited an experimental arthritis produced by the injection of formalin (Selye, 1950) or of pleuropneumonia-like organisms (Snow and Hines, 1941). Selye's interpretation of jaundice and arthritis in terms of stress and inflammatory processes suggested that the antiinflammatory effect of jaundice might be mediated by a hypersecretion of adrenal glucocorticoids (Selye, 1950).…”