“…Reports followed of remissions attending jaundice induced by the injection of bile salts and bilirubin (Thompson and Wyatt, 1938), by inoculation with infectious jaundice (Gardner, Stewart, and Mac-Callum, 1945), and by lactophenin (Hanssen, 1942), in addition to the many remissions attributed to cinchophen toxic hepatitis. In rats also, jaundice caused by the ligation of the bile duct inhibited an experimental arthritis produced by the injection of formalin (Selye, 1950) or of pleuropneumonia-like organisms (Snow and Hines, 1941). Selye's interpretation of jaundice and arthritis in terms of stress and inflammatory processes suggested that the antiinflammatory effect of jaundice might be mediated by a hypersecretion of adrenal glucocorticoids (Selye, 1950).…”