Anti-Inflammatory Effect of Obstructive Jaundice in Rats

Engerman, Ronald L.; Meyer, Roland K.

doi:10.1136/ard.18.4.309

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, different beneficial aspects linked to mild elevations of plasma bilirubin (up to 12 mg/dl) have been recognized. The anti-inflammatory effect of jaundice was already observed by Hench (1938) in patients affected by rheumatoid arthritis and by Engerman and Meyer (1959) in hyperbilirubinemic rats. More recent evidence comes from individuals with GS, where bilirubin affords cardiovascular protection (Vítek et al, 2002;Novotný and Vítek, 2003;Maruhashi et al, 2012;Gazzin et al, 2016).…”

Section: Introductionmentioning

confidence: 78%

Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?

2020

View full text Add to dashboard Cite

Among antioxidants in the human body, bilirubin has been recognized over the past 20 years to afford protection against different chronic conditions, including inflammation and cardiovascular disease. Moderate increases in plasma concentration and cellular bilirubin generation from metabolism of heme via heme oxygenase (HMOX) in virtually all tissues can modulate endothelial and vascular function and exert antioxidant and antiinflammatory roles. This review aims to provide an up-to-date and critical overview of the molecular mechanisms by which bilirubin derived from plasma or from HMOX1 activation in vascular cells affects endothelial function. Understanding the molecular actions of bilirubin may critically improve the management not only of key cardiovascular diseases, but also provide insights into a broad spectrum of pathologies driven by endothelial dysfunction. In this context, therapeutic interventions aimed at mildly increasing serum bilirubin as well as bilirubin generated endogenously by endothelial HMOX1 should be considered.

show abstract