Effect of obesity on sinonasal disease in asthma

Kanagalingam, Sivajothi; Shehab, Syed; Kaminsky, David A.; Wise, Robert A.; Lang, Jason E.; Dixon, Anne E.

doi:10.1080/02770903.2017.1341522

Cited by 15 publications

(14 citation statements)

References 44 publications

(46 reference statements)

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“…Obesity was reported to not affect the severity of sinonasal diseases in patients with asthma. 5 While childhood obesity was associated with the occurrence of acute otitis media, an association between obesity and allergic rhinitis or CRS was not observed. 6 Other studies have shown that a high BMI was associated with the prevalence of CRS.…”

Section: Discussionmentioning

confidence: 96%

Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

et al. 2021

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ObjectivesWe performed a cross-sectional analysis of data from the nationwide Korea National Health and Nutrition Examination Survey to evaluate the association between obesity and chronic rhinosinusitis with nasal polyps (CRSwNP) or without nasal polyp (CRSsNP).DesignRetrospective cross-sectional analysis of health survey data.SettingVoluntary survey of representative South Korean populations.ParticipantsIn total, 32 384 individuals aged 19 years or older with available data on CRS and obesity were included.Primary and secondary outcome measuresDiagnosis of CRSwNP or CRSsNP was performed by trained otolaryngologists through sinus endoscopy and surveys of medical history. General and central obesity was diagnosed using body mass index (BMI) and waist circumference (WC), respectively.MethodsA multivariate logistic regression analysis was used to clarify the association between CRSwNP or CRSsNP and obesity according to BMI and WC. Non-obese individuals were recruited as controls.ResultsThe prevalence of CRSwNP was higher in the general (OR, 1.438; 95% CI, 1.170 to 1.768; p<0.001) and central (OR, 1.251; 95% CI, 1.031 to 1.520; p=0.033) obesity groups than in the control group. Prevalence of CRSsNP was not correlated with obesity. In a logistic regression analysis, olfactory dysfunction (OR, 1.329; 95% CI, 1.137 to 1.553; p<0.001) and purulent discharge (OR, 1.383; 95% CI, 1.193 to 1.603; p<0.001) showed a higher incidence in the central obesity group than in the control group.ConclusionsWe demonstrated an association between CRSwNP and general and central obesity. Further investigations on the mechanism underlying this correlation are necessary for an improved understanding of the pathogenesis of CRSwNP.

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Section: Discussionmentioning

confidence: 96%

Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

et al. 2021

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“…Conversely, Kanagalingam et al . and Steele's group demonstrated obesity had no effect on severity of sinonasal disease symptoms in asthmatics or in patients prior to endoscopic sinus surgery 22,23 …”

Section: Discussionmentioning

confidence: 98%

“…21 Conversely, Kanagalingam et al and Steele's group demonstrated obesity had no effect on severity of sinonasal disease symptoms in asthmatics or in patients prior to endoscopic sinus surgery. 22,23 The link between smoking and nasal airway obstruction seemed a little stronger, however. For example, the sequelae of smoking (chronic obstructive airways disease) lead to higher SNOT-22 scores.…”

Section: Discussionmentioning

confidence: 99%

Normative data for the Nasal Obstruction Symptom Evaluation Scale in the general Australian population

Stefani

Baxter

Crittenden

et al. 2020

ANZ Journal of Surgery

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Background: Recent changes to the Australian Medicare Benefits Scheme have introduced the NOSE Score as a criteria threshold for funding rhinoplasty. On review of the literature, however, there is minimal normative Nasal Obstruction Symptom Evaluation (NOSE) score data to provide context for these changes. Methods: Participants were recruited according to the general Australian population distribution of age (18-65 years), gender and geographical locations using the market research company Pureprofile. The data included demographic details, risk factors for nasal obstruction such as smoking, obstructive sleep apnoea, use of continuous positive airway pressure, history of nasal trauma, operations to the nose and a history of cleft lip/palate and each participant completed the NOSE Scale. Analysis of data included descriptive statistics, independent t-tests and one-way analysis of variances to assess differences in NOSE scores between risk factors. Results: The NOSE score was completed by 247 males and 255 females with a mean age of 41(AE13.39) years. The cohort had a mean NOSE score of 16 (AE18.89) with a range from 0 to 95. A total of 48 respondents had a NOSE score greater than the Medicare threshold of >45. Cleft lip/palate, obstructive sleep apnoea and continuous positive airway pressure use were shown to have a statistically significant impact on NOSE score while other variables including body mass index, gender, smoking, location and other surgery to the nose were not shown to significantly impact results. Conclusions: This study found that 9.6% of the general Australian population would have a NOSE score >45 and qualify for the Medicare Benefits Scheme rhinoplasty benefit.

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“…This study included children aged 6–17 years, whereas our study investigates adults aged 16–50 years, which could be a reason for the difference in results. Kanagalingam et al found that obesity did not affect the severity of sinonasal disease in asthma [ 24 ]. That study used a validated questionnaire [ 25 ] to assess sinonasal disease severity, whereas in our study we use the EPOS criteria [ 6 ] to define chronic rhinosinusitis, which could explain the discrepancy in the results.…”

Section: Discussionmentioning

confidence: 99%

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

Clarhed

Schiöler

Fell

et al. 2022

Eur Arch Otorhinolaryngol

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Purpose Obesity is a growing, global health problem and previous cross-sectional studies have demonstrated an association between obesity and chronic rhinosinusitis (CRS). There is, however, a lack of prospective studies regarding the impact of obesity on developing (new-onset) CRS. Methods Questionnaire-based data (n = 5769) relating to new-onset CRS and Body Mass Index (BMI) were collected in 2013 and 2018 from the Telemark population study in Telemark, Norway. Odds ratios for the risk of new-onset CRS in 2018 in relation to BMI in 2013 were calculated, adjusted for smoking habits, asthma, gender and age. Results When comparing the group with normal weight (18.5 ≤ BMI < 25) with the obese group (BMI ≥ 30), the odds of new-onset CRS was 53% higher [OR 1.53 (1.11, 2.10)] in the obese group. Conclusion CRS is a multifactorial disease with different phenotypes and it is important to consider obesity when assessing patients with CRS in a clinical setting.

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Effect of obesity on sinonasal disease in asthma

Cited by 15 publications

References 44 publications

Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

Association between obesity and chronic rhinosinusitis with nasal polyps: a national population-based study

Normative data for the Nasal Obstruction Symptom Evaluation Scale in the general Australian population

BMI as a risk factor for the development of chronic rhinosinusitis: a prospective population-based study

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