Effect of nutritional recovery with soybean flour diet on body composition, energy balance and serum leptin concentration in adult rats

Cheim, Loanda Maria Gomes; Oliveira, Elisângela A; Arantes, Vanessa Cristina; Veloso, Roberto Vilela; Reis, Marise A. B.; Gomes-da-Silva, Maria Helena Gaíva; Carneiro, Everardo M.; Boschero, Antônio Carlos; Latorraca, Márcia Queiroz

doi:10.1186/1743-7075-6-34

Cited by 7 publications

(5 citation statements)

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“…In the present study, malnutrition during a critical period of development resulted in permanent somatic deficits independent of dietary protein quality during nutritional rehabilitation. In addition, rats fed a soyabean diet had similar relative food intakes but lower body weights, lower RWAT weights and decreased RWAT lipid content when compared with rats fed a casein diet, which is in accordance with the results of a previous study ( 2 ) . A soyabean diet has been associated with a reduction in fat deposits due to the action of isoflavones, which increase energy expenditure by altering the BAT activity and thyroid function ( 1 , 4 ) .…”

Section: Discussionsupporting

confidence: 91%

“…Also, an inverse correlation between UCP-1 content and food efficiency was not observed in the recovered rats (LS and LC groups) or in the CS rats. However, a lower calculated energy expenditure previously reported in recovered rats ( 2 ) was accompanied by reduced UCP-1 content in the present study.…”

Section: Discussioncontrasting

confidence: 77%

“…Nutritional recovery with a casein diet produces several metabolic abnormalities that are also present in the metabolic syndrome. In contrast, rats recovered with a soyabean flour diet showed reduced proportions of fat deposits, even though the rats ate proportionally the same amount and exhibited lower energy expenditure than those fed with an isoprotein casein diet ( 2 ) . The mechanisms whereby a soyabean diet produced these effects during the recovery of early-life malnutrition are not completely clear.…”

mentioning

confidence: 94%

“…In addition to the effects on thermogenesis, a soya diet and its components appear to affect the metabolism of white adipose tissue (WAT) and to decrease the fat-pad weight ( 2 , 3 ) . Fat accumulation is determined by the balance between fat synthesis (lipogenesis) and fat breakdown (lipolysis/fatty acid oxidation).…”

mentioning

confidence: 99%

“…Because of its reduced cost and elevated nutritional value, soyabean flour has been used as an alternative feed during recovery from early-life malnutrition ( 2 ) . Nutritional recovery with a casein diet produces several metabolic abnormalities that are also present in the metabolic syndrome.…”

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confidence: 99%

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A soyabean diet does not modify the activity of brown adipose tissue but alters the rate of lipolysis in the retroperitoneal white adipose tissue of male rats recovering from early-life malnutrition

et al. 2011

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Nutritional recovery with a soyabean diet decreases body and fat weights when compared with a casein diet. We investigated whether the reduced adiposity observed in rats recovering from early-life malnutrition with a soyabean diet results from alterations in lipid metabolism in white adipose tissue (WAT) and/or brown adipose tissue (BAT). Male rats from mothers fed either 17 or 6 % protein during pregnancy and lactation were maintained on 17 % casein (CC and LC groups), 17 % soyabean (CS and LS groups) or 6 % casein (LL group) diets over 60 d. The rats maintained on a soyabean diet had similar relative food intakes, but lower body and retroperitoneal WAT weights and a reduced lipid content in the retroperitoneal WAT. The insulin levels were lower in the recovered rats and were elevated in those fed a soyabean diet. Serum T3 concentration and uncoupling protein 1 content in the BAT were decreased in the recovered rats. The thermogenic capacity of the BAT was not affected by the soyabean diet. The lipogenesis rate in the retroperitoneal WAT was similar in all of the groups except for the LL group, which had exacerbated lipogenesis. The enhancement of the lipolysis rate by isoproterenol was decreased in white adipocytes from the soyabean-recovered rats and was elevated in adipocytes from the soyabean-control rats. Thus, in animals maintained on a soyabean diet, the proportions of fat deposits are determined by the lipolysis rate, which differs depending on the previous nutritional status. Key words: Nutritional recovery: Soyabean diet: Adipose tissue: RatsSoya-containing diets have been shown to alter several parameters involved in maintaining body homeostasis, energy expenditure and feeding behaviour (1 -3) . Soya protein and isoflavone have been reported to reduce fat-pad weight by increasing uncoupling protein 1 (UCP-1) expression in brown adipose tissue (BAT) (4) . UCP-1 is a molecule that uncouples mitochondrial oxidative phosphorylation by bypassing the electrochemical gradient across the inner membrane from * Corresponding author: M. S. F. Martins, fax þ55 65 3615 8811, email msfm.cba@gmail.com Abbreviations: BAT, brown adipose tissue; C, control; CC, offspring born to and suckled by mothers fed a control diet that were fed a control diet after weaning; CS, offspring born to and suckled by mothers fed a control diet that were fed a soyabean diet with 17 % protein after weaning; HOMA-IR, homeostasis model assessment of insulin resistance; LC, offspring of mothers fed a low-protein diet that were fed a control diet after weaning; LL, offspring of mothers fed a low-protein diet that were fed a low-protein diet after weaning; LP, low-protein; LS, offspring of mothers fed a low-protein diet that were fed a soyabean diet containing 17 % protein after weaning; RWAT, retroperitoneal white adipose tissue; Tris, 2-amino-2-hydroxymethyl-propane-1,3-diol; UCP-1, uncoupling protein 1; WAT, white adipose tissue.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 77%

mentioning

confidence: 94%

mentioning

confidence: 99%

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confidence: 99%

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