Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat

Takase, Luiz Fernando; Nogueira, Maria Inês; Bland, Sondra T.; Baratta, Michael V.; Watkins, Linda R.; Maier, Steven F.; Fornal, Casimir A.; Jacobs, Barry L.

doi:10.1016/j.bbr.2005.04.008

Cited by 53 publications

(50 citation statements)

References 18 publications

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“…Behavioral testing procedures were similar to previously used protocols (Greenwood et al 2003(Greenwood et al , 2007Maier 1990;Takase et al 2005). Shock-elicited freezing and shuttle box escape behavior took place in shuttle boxes (50.8×25.4×30.48 cm, Coulbourn Instruments, Whitehall, PA, USA), consisting of a grid floor and Plexiglas walls, placed in individual sound-attenuating chambers.…”

Section: Behavioral Testingmentioning

confidence: 99%

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The effects of the selective 5-HT2C receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats

2008

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Section: Behavioral Testingmentioning

confidence: 99%

“…The uncontrollable tail shock procedure followed protocols known to produce exaggerated shock-elicited freezing and shuttle box escape deficits Takase et al 2005). Nonstressed control rats were left undisturbed in their home cages while stressed rats were exposed to uncontrollable tail shock.…”

Section: Uncontrollable Stressmentioning

confidence: 99%

The effects of the selective 5-HT2C receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats

2008

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“…Electrodes attached to the tail delivered 100 5-s tail shocks (1.5 mA) on a 1-min variable-interval schedule (Coulbourn Instruments, Allentown, PA, USA). This number and intensity of tail shocks were chosen based on prior work using this same stressor procedure (Greenwood et al 2003(Greenwood et al , 2007bMaier 1990) and a titration of the number of tail shocks required to produce escape deficits (Takase et al 2005). Following termination of shock, rats were returned to their home cages.…”

Section: Uncontrollable Stressmentioning

confidence: 99%

Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise

et al. 2008

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Rationale-Although selective 5-HT reuptake inhibitors (SSRIs) can reduce anxiety after chronic treatment, acute SSRI administration is associated with an increase in anxiety consistent with an acute increase in 5-HT neurotransmission. Exercise is anxiolytic in humans, and wheel running prevents anxiety-like behavioral consequences of uncontrollable stress in rats, but the effects of exercise on acute fluoxetine-induced anxiety-like behaviors are unknown.Objectives-The current studies tested the hypothesis that acute administration of the SSRI fluoxetine would produce behaviors in rats resembling those produced by uncontrollable stress and that these behaviors would be blocked by prior wheel running.Results-Adult, male Fisher 344 rats administered moderate (10 mg/kg) or high (20 mg/kg) doses of fluoxetine demonstrated exaggerated shock-elicited freezing and an interference with shuttle box escape compared to rats given either saline or low-dose fluoxetine (2.5 mg/kg). Fluoxetine-induced behaviors were similar to, but smaller in magnitude than, those produced by uncontrollable stress and were blocked by pretreatment with the 5-HT 2C receptor antagonist SB 242084 (1 mg/kg). Rats allowed access to running wheels for 6 weeks were protected against the anxiety-like behaviors produced by a single injection of fluoxetine (10 mg/kg).Conclusions-Behavioral effects of acute fluoxetine administration resemble those produced by uncontrollable stress. Results are consistent with the idea that exercise can produce resistance against the anxiogenic effects of acute increases in 5-HT and suggest that acute behavioral effects of antidepressants can depend on history of physical activity.

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“…This is supported by cFos experiments showing that only strong acute stress induces expression of this marker [98,100,101]. However, galanin transcript levels in the DR might be increased following exposure to prolonged stress or in genetically predisposed animals.…”

Section: Galanin Systems In Depression: Potential Mechanismsmentioning

confidence: 78%

Galanin – 25 years with a multitalented neuropeptide

Kuteeva

Hökfelt

Wardi

et al. 2008

Cell. Mol. Life Sci.

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The pathophysiology of depression remains unclear, but involves disturbances in brain monoaminergic transmission. Current antidepressant drugs, which act by enhancing this type of transmission, have limited therapeutic efficacy in a number of patients, and not rarely serious side-effects. Increasing evidence suggests that neuropeptides, including galanin, can be of relevance in mood disorders. Galanin is coexpressed with and modulates noradrenaline and serotonin systems, both implicated in depression. Pharmacological and genetic studies have suggested a role for galanin in depression-like behaviour in rodents, whereby the receptor subtype involved appears to play an important role. Thus, stimulation of GalR1 and/or GalR3 receptors results in depression-like phenotype, while activation of the GalR2 receptor attenuates depression-like behaviour. These findings suggest that galanin receptor subtypes represent targets for development of novel antidepressant drugs.

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Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat

Cited by 53 publications

References 18 publications

The effects of the selective 5-HT2C receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats

The effects of the selective 5-HT2C receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats

Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise

Galanin – 25 years with a multitalented neuropeptide

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