Effect of novel water soluble curcumin derivative on experimental type- 1 diabetes mellitus (short term study)

Aziz, M.M. Abdel; El-Asmar, M.F.; El-Ibrashy, Ibrahim N; Rezq, Ameen M; Al-Malki, Abdulrahman L.; Wassef, M.; Fouad, Hanan; Ahmed, Hanan H.; Taha, Fatma; Hassouna, Amira; Morsi, Heba

doi:10.1186/1758-5996-4-30

Cited by 52 publications

(29 citation statements)

References 50 publications

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“…Curcumin is a powerful antioxidant agent; therefore, it can serve as a protective agent for pancreatic islet cells by inhibiting β‐cell apoptosis (Al‐ali, Abdel, & El‐badry, ). Although curcumin was explored by many researchers as a hypoglycemic agent (Abdel Aziz et al, ), a comprehensive comparison between oral curcumin use as a food supplement and parentral administration is needed.…”

Section: Discussionmentioning

confidence: 99%

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

et al. 2019

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Herbal remedies have been used for centuries to ameliorate complications of diabetes mellitus (DM). The aim of this study is to compare the effects of the oral curcumin supplement versus parenteral administration of turmeric extract on diabetic complications in a streptozocin (STZ) diabetic model. STZ DM rats received low and high doses turmeric extract intraperitoneally as well as oral curcumin. Curcumin and turmeric extracts significantly reduced blood glucose and creatinine levels, but not urea, and caused an increase in uric acid. Low dose improved liver enzymes, while higher dose and oral administration caused an increase in the ALT and AST. All groups showed an improvement in the serum cholesterol, while the triglycerides were not improved in the high and oral treatment. Histological evaluation showed islet cell protection. High‐dose injection showed almost intact renal corpuscles as well as tubular structures with minimal degeneration. Treatment showed limited protection of Liver tissue. Practical application Curcumin has been heavily marketed as a protective agent. The current study shows some potential risk of curcumin use. Oral and injectable curcumin should be used with caution. Turmeric extract and oral curcumin supplement showed protective effects on pancreatic, and renal structure and function. Although both did show some improvement in liver function, higher doses caused disturbance in liver enzymes and did not show histological evidence of liver tissue protection.

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Section: Discussionmentioning

confidence: 99%

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

et al. 2019

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“…Additionally, in vivo studies in humans and animals demonstrated curcumin’s effectiveness in decreasing the severity of periodontal diseases (Elburki et al , 2014, Nagasri et al , 2015, Bakir et al , 2016, Elburki et al , 2016). Curcumin has been investigated in many clinical trials for treatment of several disorders, such as ulcerative colitis (Baliga et al , 2012), breast cancer (Nagaraju et al , 2012), pancreatic cancer (Veeraraghavan et al , 2011), and diabetes (Abdel Aziz et al , 2012). Additional investigation into the role of curcumin in MMP activation and regulation in periodontal diseases is further warranted, given these reports and the current study findings.…”

Section: Discussionmentioning

confidence: 99%

Treponema denticolaincreases MMP-2 expression and activation in the periodontium via reversible DNA and histone modifications

Ateia

Sutthiboonyapan

Kamarajan

et al. 2018

Cellular Microbiology

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Host-derived matrix metalloproteinases (MMPs) and bacterial proteases mediate destruction of extracellular matrices and supporting alveolar bone in periodontitis. The Treponema denticola dentilisin protease induces MMP-2 expression and activation in periodontal ligament (PDL) cells, and dentilisin-mediated activation of pro-MMP-2 is required for cellular fibronectin degradation. Here, we report that T. denticola regulates MMP-2 expression through epigenetic modifications in the periodontium. PDL cells were treated with epigenetic enzyme inhibitors before or after T. denticola challenge. Fibronectin fragmentation, MMP-2 expression, and activation were assessed by immunoblot, zymography, and qRT-PCR, respectively. Chromatin modification enzyme expression in T. denticola-challenged PDL cells and periodontal tissues were evaluated using gene arrays. Several classes of epigenetic enzymes showed significant alterations in transcription in diseased tissue and T. denticola-challenged PDL cells. T. denticola-mediated MMP-2 expression and activation were significantly reduced in PDL cells treated with inhibitors of aurora kinases and histone deacetylases. In contrast, DNA methyltransferase inhibitors had little effect, and inhibitors of histone acetyltransferases, methyltransferases, and demethylases exacerbated T. denticola-mediated MMP-2 expression and activation. Chronic epigenetic changes in periodontal tissues mediated by T. denticola or other oral microbes may contribute to the limited success of conventional treatment of chronic periodontitis and may be amenable to therapeutic reversal.

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“…Similarly, in the present study TNF- α expression was significantly increased in the diabetic untreated group compared with the normal control group, and the oat-treated groups showed significantly lower levels of TNF- α than the diabetic untreated group. Other studies also reported that antioxidants dose-dependently inhibit inflammatory markers like TNF- α , IL-6, and IL1 β gene expression in the cells of chronic diseases and their release from a human cancer cell line [53–58]. …”

Section: Discussionmentioning

confidence: 99%

Oat Attenuation of Hyperglycemia-Induced Retinal Oxidative Stress and NF-B Activation in Streptozotocin-Induced Diabetic Rats

Al-Malki

2013

Evidence-Based Complementary and Alternative Medicine

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The overproduction of reactive oxygen species (ROS) plays a central role in the pathogenesis of endothelial damage in diabetes. To assess the effect of oat on experimental diabetic retinopathy, five groups of Albino rats were studied: nondiabetic control, untreated diabetic, and diabetic rats treated with 5%, 10%, and 20% (W/W) oat of the diet for 12 weeks. Novel data were obtained in this study indicating a protective role of oat against oxidative stress and diabetic retinopathy. The effects of oat on parameters of oxidative stress, AGE, and nuclear factor kappa B (NF-κB) were assessed by ELISA and NF-κB activation by electrophoretic mobility shift assay. Tumor necrosis factor alpha (TNFα) and vascular endothelial growth factor (VEGF) were also determined. After 12 weeks of diabetes, oat treatment reduced blood glucose levels, HbA1c, all oxidative stress markers, CML, normalized NF-κB activation and TNFα expression. Furthermore it reduced VEGF in the diabetic retina by 43% (P < 0.001). In conclusion, oat modulates microvascular damage through normalized pathways downstream of ROS overproduction and reduction of NF-κB and its controlled genes activation, which may provide additional endothelial protection.

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Effect of novel water soluble curcumin derivative on experimental type- 1 diabetes mellitus (short term study)

Cited by 52 publications

References 50 publications

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

Treponema denticolaincreases MMP-2 expression and activation in the periodontium via reversible DNA and histone modifications

Oat Attenuation of Hyperglycemia-Induced Retinal Oxidative Stress and NF-B Activation in Streptozotocin-Induced Diabetic Rats

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