Effect of nonsteroidal anti-inflammatory drugs on Barrett's esophagus risk: a systematic review and meta-analysis

Zhang, Jin-Jia; Wu, Huadong; Wang, Rongying

doi:10.1016/j.clinre.2020.09.013

Cited by 3 publications

(4 citation statements)

References 37 publications

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“…Obesity, smoking, and alcohol consumption are also reported as risk factors for BE, whereas Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs (NSAIDs), and proton pump inhibitors (PPIs) have been reported to have protective effects [ 9 , 14 ]. However, other studies have reported contradictory results regarding the impact of the above mentioned risk factors; thus, it has yet to be elucidated whether these are truly risk factors for BE [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Barrett’s Esophagus and Its Risk Factors: A Cross-Sectional Study of 10,122 Subjects at a Japanese Health Examination Center

Kubota¹,

Takahashi²,

Yamamichi³

et al. 2022

Digestion

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Introduction: Helicobacter pylori eradication is expected to significantly change the prevalence of Barrett’s esophagus (BE). However, few reports on this relationship exist. We analyzed the risk factors of BE using the current consensus on length of BE considering H. pylori infection status. Methods: We analyzed 10,122 individuals (5,962 men; mean age = 52.9 ± 9.9 years) who had undergone esophagogastroduodenoscopy as part of a medical checkup. Correlations among factors including H. pylori infectious status, endoscopic findings, and BE ≥1 cm were analyzed. Results: Prevalence of BE, long-segment BE, and esophageal adenocarcinoma was 22.5%, 0.014%, and 0%, respectively. Logistic regression analysis showed that the risk factors for BE were hiatal hernia (odds ratio [OR]: 2.89 [2.59–3.24]), female sex (OR: 0.52 [0.46–0.59]), social drinking (OR:0.77 [0.68–0.87]), H. pylori eradication therapy (OR: 1.34 [1.19–1.51]), proton pump inhibitor (PPI) use (OR: 1.52 [1.18–1.96]), bile reflux (OR: 1.18 [1.04–1.33]), age ≥50 years (OR: 1.13 [1.02–1.26]), and nonsteroidal anti-inflammatory drug (NSAID) use (OR: 1.29 [1.02–1.62]). Although reflux esophagitis (RE) was more common in H. pylori-negative patients (17.2%) than in those after H. pylori eradication therapy (11.8%, p < 0.00001), the latter was correlated with BE, disputing RE as a strong risk factor for BE. Therefore, we conducted a subgroup analysis; most of the risk factors except for PPI use (p = 0.75), H2-receptor antagonist use (p = 0.078), and atrophic gastritis absence (p = 0.72) were positively correlated with BE after H. pylori eradication therapy compared with H. pylori-negative status. Conclusions: H. pylori eradication, bile reflux, PPI use, and NSAID use were risk factors for BE along with hiatal hernia, male sex, and older age.

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Section: Introductionmentioning

confidence: 99%

Analysis of Barrett’s Esophagus and Its Risk Factors: A Cross-Sectional Study of 10,122 Subjects at a Japanese Health Examination Center

Kubota¹,

Takahashi²,

Yamamichi³

et al. 2022

Digestion

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“…On the other hand, inappropriate cooking time or temperature could create harmful byproducts, including advanced glycation end products, which have been proved to induce inflammatory effects. 47 Inflammation was one of the pathological characteristics of BE, and the use of nonsteroidal anti-inflammatory drugs was related to a lower BE risk as confirmed by a highquality meta-analysis, 48 so the harmful byproducts created during cooking might be associated with the BE risk; however, further study is required to confirm this conclusion. Besides, some cooking techniques, especially the methods of deep frying and sautéing, also led to increased fat content in cooked vegetables.…”

Section: Food and Function Papermentioning

confidence: 95%

Causal relationships between dietary habits and Barrett's esophagus risk: a univariable and multivariable Mendelian randomization study

Junhai,

Suqi,

Beiying

et al. 2024

Food Funct.

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“…NSAIDs, particularly aspirin, were associated with a reduced risk of BE [ 153 , 154 ]. Importantly, the first of the mentioned studies [ 153 ] proved people with BE were less likely to use aspirin than the control group (OR = 0.59; 95% CI: 0.39–0.87).…”

Section: Be Preventionmentioning

confidence: 99%

“…Additionally, moderate and high total aspirin intake was associated with lower risk of BE (at least weekly use for less than 5 years (moderate total intake): OR = 0.41; 95% CI: 0.23–0.73; for weekly, or more often use for over 5 years (high total intake): OR = 0.46; 95% CI: 0.26–0.79). The second study [ 154 ], a meta-analysis, demonstrated that NSAIDs could reduce BE risk (OR = 0.84; 95% CI: 0.75–0.94, p < 0.05). However, when subgroup analysis was performed, this relation was only evident in females.…”

Section: Be Preventionmentioning

confidence: 99%

Diagnosis and Management of Barrett’s Esophagus

Mejza

Małecka-Wojciesko

2023

JCM

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Barrett’s esophagus is a metaplastic change of esophageal mucosa, which can be characterized by its salmon-colored lining and the presence of columnar epithelium with goblet cells. It is a well-established precancerous state of esophageal adenocarcinoma, a tumor with very poor survival rates, which incidence is rapidly growing. Despite numerous research, the debate about its diagnosis and management is still ongoing. This article aims to provide an overview of the current recommendations and new discoveries regarding the subject.

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Effect of nonsteroidal anti-inflammatory drugs on Barrett's esophagus risk: a systematic review and meta-analysis

Cited by 3 publications

References 37 publications

Analysis of Barrett’s Esophagus and Its Risk Factors: A Cross-Sectional Study of 10,122 Subjects at a Japanese Health Examination Center

Analysis of Barrett’s Esophagus and Its Risk Factors: A Cross-Sectional Study of 10,122 Subjects at a Japanese Health Examination Center

Causal relationships between dietary habits and Barrett's esophagus risk: a univariable and multivariable Mendelian randomization study

Diagnosis and Management of Barrett’s Esophagus

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