Effect of Nitrofurantoin (Furadantin) on Morbidity After Transurethral Prostatic Resection

Orr, Louis M.

doi:10.1001/jama.1958.02990290009003

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…Nitrofurantoin is used commonly to treat acute simple infection of the lower urinary tract caused by bacteria sensitive to it ( Orr et al, 1958 ), such as Escherichia coli , enterococci and Staphylococcus species. Nitrofurantoin can also be used for the prevention of urinary-tract infection.…”

Section: Application In Analyses Of Chemical Drugsmentioning

confidence: 99%

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Huang

Deng

Xia

et al. 2023

Front. Bioeng. Biotechnol.

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Terahertz time-domain spectroscopy is an analytical method using terahertz time-domain pulses to study the physical and chemical properties of substances. It has strong potential for application in pharmaceutical analyses as an original non-destructive, efficient and convenient technology for spectral detection. This review briefly introduces the working principle of terahertz time-domain spectroscopy technology, focuses on the research achievements of this technology in analyses of chemical drugs, traditional Chinese medicine and biological drugs in the past decade. We also reveal the scientific feasibility of practical application of terahertz time-domain spectroscopy for pharmaceutical detection. Finally, we discuss the problems in practical application of terahertz time-domain spectroscopy technology, and the prospect of further development of this technology in pharmaceutical analyses. We hope that this review can provide a reference for application of terahertz time-domain spectroscopy technology in pharmaceutical analyses in the future.

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Section: Application In Analyses Of Chemical Drugsmentioning

confidence: 99%

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Huang

Deng

Xia

et al. 2023

Front. Bioeng. Biotechnol.

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“…Nitrofurantoin (NF, ( E )-1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione, see Figure ) is an antibacterial drug widely used for the treatment of urinary tract infections. , NF forms 2 polymorphs α (LABJON01) and β (LABJON), as well as 2 monohydrates, and multiple solvates. − Polymorph β can be easily prepared in crystallization from acetone and multiple other solvents. , In contrast, for the crystallization of pure form α only a rather complex stepwise procedure using acetic acid, water and acetone as solvents has been reported …”

Section: Introductionmentioning

confidence: 99%

“…38 N i t r o f u r a n t o i n ( N F , ( E ) -1 -[ ( 5 -n i t r o -2 -f u r y l )methylideneamino]imidazolidine-2,4-dione, see Figure 1) is an antibacterial drug widely used for the treatment of urinary tract infections. 39,40 NF forms 2 polymorphs α (LABJON01) 41 and β (LABJON), 42 as well as 2 monohydrates, 43 and multiple solvates. 44−46 Polymorph β can be easily prepared in crystallization from acetone and multiple other solvents.…”

Section: ■ Introductionmentioning

confidence: 99%

Switching Nitrofurantoin Polymorphic Outcome in Solvent-Mediated Phase Transformation and Crystallization Using Solvent and Additives

Be̅rziņš

Trimdale-Deksne

Belyakov

et al. 2023

Crystal Growth & Design

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We demonstrate that several additives and solvents allow switching the polymorphic outcome of solvent-mediated phase transformation experiments and crystallization of the antibacterial drug nitrofurantoin. Polymorph β is obtained from most of the solvents, whereas the selection of alcohols as solvents or the use of crystallization additives provides the formation of polymorph α. We also demonstrate that this can be linked to reversed apparent relative solubility of nitrofurantoin polymorphs in these solvents or in the presence of the respective additives. We propose that this could be caused by different surface−additive and surface−solvent interactions formed by each of the nitrofurantoin polymorphs, which would change the relative surface energy of polymorphs.

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“…38 Nitrofurantoin (NF, (E)-1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione, see Figure 1) is an antibacterial drug widely used for the treatment of urinary tract infections. [39][40] NF forms 2 polymorphs α (LABJON01) 41 and β (LABJON) 42 as well as 2 monohydrates, 43 and multiple solvates. [44][45][46] Polymorph β can be easily prepared in crystallization from acetone and multiple other solvents.…”

Section: Introductionmentioning

confidence: 99%

Switching nitrofurantoin polymorphic outcome in solvent mediated phase transformation and crystallization using solvent and additives

Be̅rziņš

Trimdale-Deksne

Belyakov

et al. 2023

Preprint

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We demonstrate that several additives and solvents allow switching the polymorphic outcome of solvent mediated phase transformation experiments and crystallization of the antibacterial drug nitrofurantoin. Polymorph β is obtained from most of the solvents, whereas selection of alcohols as solvents or use of crystallization additives provides formation of polymorph α. We also demonstrate that this can be linked to reversed apparent relative solubility of nitrofurantoin polymorphs in these solvents or in presence of the respective additives. We propose that this could be caused by different surface-additive and surface-solvent interactions formed by each of the nitrofurantoin polymorphs, which would change the relative surface energy of polymorphs.

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Effect of Nitrofurantoin (Furadantin) on Morbidity After Transurethral Prostatic Resection

Cited by 10 publications

References 7 publications

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Progress in application of terahertz time-domain spectroscopy for pharmaceutical analyses

Switching Nitrofurantoin Polymorphic Outcome in Solvent-Mediated Phase Transformation and Crystallization Using Solvent and Additives

Switching nitrofurantoin polymorphic outcome in solvent mediated phase transformation and crystallization using solvent and additives

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