Effect of nitric oxide reduction on arterial thrombosis

Costa, Dário Alves da Silva; Benincasa, Giuditta; Lucchese, Roberta; Infante, Teresa; Nicoletti, Giovanni Francesco; Napoli, Claudio

doi:10.1080/14017431.2019.1581943

Cited by 26 publications

(24 citation statements)

References 68 publications

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“…Research on the convoluted physicochemical properties of free radicals and NO is helpful in revealing the dual roles of RNS in redox signalling and oxidative stress. NO, a vital signalling molecule, has been well reviewed in previous reports, but it is striking to clarify how NO communicates information to achieve signal transduction. In organisms, NO is generated through a nitric oxide synthase (NOS) catalyzed reaction of L‐arginine.…”

Section: Cross‐talk Between Ros and Rnsmentioning

confidence: 99%

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Huang

2019

Acta Physiologica

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Oxidative stress is recognized as free radical dyshomeostasis, which has damaging effects on proteins, lipids and DNA. However, during cell differentiation and proliferation and other normal physiological processes, free radicals play a pivotal role in message transmission and are considered important messengers. Organisms maintain free radical homeostasis through a sophisticated regulatory system in which these "2faced" molecules play appropriate roles under physiological and pathological conditions. Reactive oxygen species (ROS), including a large number of free radicals, act as redox signalling molecules in essential cellular signalling pathways, including cell differentiation and proliferation. However, excessive ROS levels can induce oxidative stress, which is an important risk factor for diabetes, cancer and cardiovascular disease. An overall comprehensive understanding of ROS is beneficial for understanding the pathogenesis of certain diseases and finding new therapeutic treatments.This review primarily focuses on ROS cellular localization, sources, chemistry and molecular targets to determine how to distinguish between the roles of ROS as messengers and in oxidative stress. K E Y W O R D Shomeostasis, oxidative stress, reactive oxygen, redox signalling, signalling pathways 2 of 16 | HUANG ANd LI for the development of new therapeutic strategies for cancer and cardiovascular disease. | SOURCES AND PHYSICOCHEMICAL PROPERTIES OF ROS | ROS sourcessecond messengers, what are the corresponding acceptors for these special ROS? To better recognize ROS, a new tool that can monitor changes in ROS levels and position in real time must be developed. Determining how to utilize the characteristics of ROS to treat diseases, such as cardiovascular disease, diabetes, autoimmune diseases, cancer and Alzheimer's diseases, is worth further exploration.

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Section: Cross‐talk Between Ros and Rnsmentioning

confidence: 99%

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Huang

2019

Acta Physiologica

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“…The different families of NOS are encoded by separate genes [12,13]. There are different isoforms of NOS classified as either constitutive (cNOS) or inducible (iNOS).…”

Section: Classification Of Nitric Oxide Synthasementioning

confidence: 99%

Nitric Oxide Balance in Health and Diseases: Implications for New Treatment Strategies

Akanji¹,

Adeyanju²,

Rotimi³

et al. 2020

TOBIOCJ

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Nitric Oxide (NO) is an essential signaling molecule with diverse physiological functions in humans. The steady-state concentration and site of production of nitric oxide determine its effects in biological systems. The human cells are exposed to both beneficial and harmful effects of NO. These dual effects of NO could depend on its local concentration in the cells. Additionally, the rate of synthesis, translocation, direct interaction with other molecules, and signals contribute to the biochemical and physiological effects of NO. In this review, the biochemical and physiological role of NO, particularly in health and disease as touching on cell signaling, oxidative stress, immunity, as well as cardiovascular protection amongst others, is focused on. Therefore, this review objectively discusses the dual functionality of NO in living cells.

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“…A drastic role is played by a balance between vasodilators and vasoconstrictors in the control of blood flow and pressure in healthy persons and patients with cardiovascular diseases. A wide range of vascular actions are evoked by a biological signaling molecule: nitric oxide (NO); essentially, vasorelaxation 37 , anti-inflammatory activity 38 , antiplatelet activity 39 , and its effect to counteract malaria infection 40 .…”

Section: : Effect Of 4 Week Oral Treatment With Tap Water (Control Gmentioning

confidence: 99%

Untitled

2019

IJPSR

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Rhus pentaphylla (Jacq.) Desf. (Searsia pentaphylla (Jacq.) FA. Barkley) is used for its colorant and tanning properties by the local population. The bark, leaves, roots, and fruits are employed in Moroccan traditional medicine to treat gastrointestinal disorders and diarrhea. Nevertheless, the pharmacological properties of R. pentaphylla on cardiovascular diseases have not yet been presented. This study was carried out to explore the vasorelaxant effect of the aqueous extract (decoction) from the leaves of R. pentaphylla (RpAE), its mechanism of action, and its antihypertensive effect. The results of this study demonstrate that RpAE induces a dose-dependent effect on isolated rat aorta. The vasorelaxation is endothelium-dependent via the muscarinic receptor, Calmodulin/eNOS/sGC/cGMP/PKG signaling pathway through the activation of SERCA pump, the inhibition of VOCC, and opening of K Ca 2+ channels. In-vivo, RpAE induces antihypertensive effect, ameliorates diuresis, and vascular reactivity on L-NAME induced hypertensive rats. The oral administration of RpAE reveals no mortality or toxicity. This is the first study in Morocco showing vasorelaxant and antihypertensive effects of species belonging to genus Rhus. INTRODUCTION: Hypertension is one of the ultimate prevalent and modifiable risk factor for cardiovascular diseases (CVD) all over the world 1. Certainly, it is an imminent risk factor for endothelial dysfunction 2 , diabetes 3 , atherosclerosis 4 , renal dysfunction 5 , coronary artery disease 6 , congestive heart failure, and stroke 7. It is also one of the important preventable causes of disability, morbidity, and mortality throughout the world 8 .

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Effect of nitric oxide reduction on arterial thrombosis

Cited by 26 publications

References 68 publications

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Nitric Oxide Balance in Health and Diseases: Implications for New Treatment Strategies

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