Effect of Nicotin, Cystosin, Lobelin, Coniin, Piperidin and Quaternary Ammonias on Adrenal Secretion

Houssay, B. A.; Molinelli, Elisa

doi:10.1152/ajplegacy.1926.76.3.551

Cited by 8 publications

(1 citation statement)

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“…Smokers commonly experience symptoms which are related to altered activity of the large intestine. For example, Schnedorf and Ivy (1939) reported that, in healthy human volunteers, smoking was canine small intestinal activity, an observation which has been confirmed repeatedly (Houssay and Molinelli, 1926;Mulinos, 1927-28;Hamet, 1930;Carlson et al, 1970a). To our knowledge, no study of the effects of nicotine on the cblon has been reported.…”

Section: Introductionmentioning

confidence: 88%

Effects of nicotine and tyramine on contractile activity of the colon

Weisbrodt

Hug

Schmiege

et al. 1970

European Journal of Pharmacology

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Contractile activity of the descending colon of the anesthetized dog was monitored with strain gage force transducers. Nicotine and tyramine caused primarily a relaxation of the circular and longitudinal muscle. A secondary stimulation frequently followed the inhibition. Adrenalectomy partially antagonized the effects of nicotine. Xylocholine and reserpine petreatment reduced the early portion of the inhibitory response to nicotine. Hexamethonium or a combination of adrenalectomy with either xylocholine or reserpine pretreatment abolished the effects of nicotine. The effects of tyramine were antagonized by cocaine and reserpine-pretreatment. Tolazoline and propranolol (in combination) reduced the effects of both nicotine and tyramine. We conclude that both nicotine and tyramine relaxed the colon by releasing catecholamines. Nicotine caused release from the adrenal glands and adrenergic nerve endings; tyramine produced release from the adrenergic nerve endings. Nicotine Catecholamines Colonic motility Tyramine Gastrointestinal tract Strain gage force transducers * The study was supported by a grant from the American Medical Association, Education and Research Foundation. It represents a portion of a doctoral dissertation by N.W. Weisbrodt.

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Section: Introductionmentioning

confidence: 88%