Effect of nickel oxide substitution on bioactivity and mechanical properties of bioactive glass

Abstract

A small amount of nickel oxide is doped in bioglass R system and it is replaced by silica. The use of 45S5 glass composition is one such material able to bond strongly to bone within 42 days. The 45S5 bioglass R system develops a hydroxyl carbonate apatite (HCA) layer, which is chemically and crystallographically similar to mineral phase of bone. But it has low fracture toughness and mechanical weakness due to an amorphous glass network and it is not compatible for load-bearing applications. In the present work, the effect of addition of nickel oxide that annualizes the improvement in its mechanical strength and bioactivity is studied. Bioactivity of base glass and doped glass samples were tested through their HCA abilities by immersing them in simulated body fluid (SBF) for different days. The formation of HCA was confirmed by FTIR spectroscopy and pH measurement. Densities and mechanical properties of samples were also increased considerably by increasing the concentration of nickel oxide.

Bioactivity and properties of a dental adhesive functionalized with polyhedral oligomeric silsesquioxanes (POSS) and bioactive glass

“…and also lead to HA formation in dental resin [4]. The local increase of pH due to the release of ions from bioactive glass [42,43] accelerates the bioactivity by decreasing the HA solubility [44]. Since no ions can be released from both POSS particles the process of Ca/P precipitation and HA formation in a case of POSS particles in the adhesive is conditional upon the presence of calcium and phosphate ions.…”

“…Higher concentration of bioactive particles results in more nucleation points on the surface, if dispersed properly, which initiates the formation of crystals simultaneously on more places over the specimen [4]. The growth rate as well as the critical radius for nucleation drop rapidly with the reduction of calcium and phosphate ions in the solution [44]. Due to the relatively high amount of these ions in the artificial saliva used in this study, several layers of plate-like crystals could grow over each nucleation point and expand up to 20 µm (Fig.…”

Development of Zirconia Substituted 1393 Bioactive Glass for Orthopaedic Application

“…12 2+ and Na + ions from the sample surface 22,23,25,26 . The sample number G-4 with higher zirconia content was found to show maximum pH value may be due to high rate of dissolution as compared to base sample G-1.…”

“…The total range of density is found to be from 2.44 g/ cm 3 to 2.495 g/cm 3 . The density of bioactive glass is directly proportional to the solidity of the configuration 22,23,25,26 . Here G-4 and G-5 glass are showing approximately same density which means these materials are suitable for making scaffolds for bone tissue engineering 47 .…”

“…In vitro evaluation has also shown that ZrO 2 is not cytotoxic [19][20][21] . Vyas et al, [22][23][24][25][26][27] in an earlier investigation had also shown that the addition of cobalt oxide and nickel oxide up to 0-2.0 wt% in 45S5 glass (BG) and glassceramic (BGC) has resulted an increase physicomechanical properties and bioactivity of their samples due to formation Co-O-Si and Ni-O-Si bonds. Tripathi et al, 28 have also found the characterization of Li 2 O, CaO, Al 2 O 3 , P 2 O 5 ,SiO 2 glasses as bioactive material and all the elastic moduli values were establish to increase with the increasing in Al 2 O 3 /Li 2 O ratio.…”