Development of Zirconia Substituted 1393 Bioactive Glass for Orthopaedic Application

Yadav, Sandeep; Ray, Sarthak; Ershad,; Vyas, Vikash Kumar; Prasad, S. K.; Ali, Akher; Yadav, Sushma; Majhi, Manas Ranjan; Pyare, Ram

doi:10.13005/ojc/330605

Cited by 15 publications

(1 citation statement)

References 30 publications

(43 reference statements)

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“…Several approaches have been explored to enhance the biological fixation process and increase bioactivity. Many researchers have investigated the effects of an ion substitution and differences in the composition of chemicals on the qualities of biologically active glass, including its ability to deposit hydroxyapatite [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Some investigations examined the relationship between electrical properties and hydroxyl apatite formation.…”

Section: Introductionmentioning

confidence: 99%

Impact of electrical polarization in the production of hydroxyapatite on ZnO substituted 45S5 bioglass

Singh,

Jaiswal,

Singh

et al. 2024

Phys. Scr.

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In the present investigation, we show the role of dielectric permittivity in the growth of hydroxyl carbonate apatite over ZnO-substituted 45S5 bioglass. ZnO is incorporated here in 45S5 bioglass because of its incipient dielectricity. Zinc is a necessary element for the formation, mineralization, development and maintenance of healthy bones. Here, the bioactive glass ZBG, having the general composition of 46.1 SiO2, 26.9 CaO, 2.6 P2O5, 24.4-X Na2O, and X ZnO (here X = 0 to 3 mole %), was synthesized using the traditional melting technique. The ZBG bioglass samples underwent electro-thermal poling with a voltage value of 10 kV at a temperature of 500 °C for 1 h. The impact of substituting Na2O with ZnO on the in-vitro bioactive property following submersion in simulated bodily fluid (SBF) was examined using the Fourier transform of infrared spectroscopy (FTIR) and x-ray diffraction (XRD). A comparison has been made between the dielectric constant (ε) and alternating current conductivity of unpolarized and polarized hydroxyl carbonate apatite (HCA) formed samples subjected to a 90 kV cm−1 polarisation field. Additionally, the influence of electrical poling on the ZBG samples that were created was examined via the use of XRD, scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDX), and atomic force microscopy (AFM) research. The dielectric characteristics of bioactive glasses were improved by substituting Na2O with ZnO, as seen in the study. The ZBG samples immersed in SBF solution enhance the hydroxyl calcium phosphate precipitation process due to electrical interaction with the polarized sample. This result shows us that N-poled samples are more suitable for orthopaedic applications. Thus, our main aim of the present investigation is to increase the bioactivity of 45S5 glasses substituted with ZnO after polarization, which will be more suitable for orthopaedic implants.

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Section: Introductionmentioning

confidence: 99%

Impact of electrical polarization in the production of hydroxyapatite on ZnO substituted 45S5 bioglass

Singh,

Jaiswal,

Singh

et al. 2024

Phys. Scr.

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Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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Study of Human Osteosarcoma Cell Line Growth, Hemocompatibility, In-vitro Analysis and Physical Properties of V2O5 Substituted Borosilicate Glass

Singh,

Goswami,

Koch

et al. 2024

Silicon

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Development of Zirconia Substituted 1393 Bioactive Glass for Orthopaedic Application

Cited by 15 publications

References 30 publications

Impact of electrical polarization in the production of hydroxyapatite on ZnO substituted 45S5 bioglass

Impact of electrical polarization in the production of hydroxyapatite on ZnO substituted 45S5 bioglass

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Study of Human Osteosarcoma Cell Line Growth, Hemocompatibility, In-vitro Analysis and Physical Properties of V2O5 Substituted Borosilicate Glass

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