Effect of neonatal exposure to endosulfan on myometrial adaptation during early pregnancy and labor in rats

Alarcón, Ramiro; Varayoud, Jorgelina; Luque, Enrique H.; Milesi, María Mercedes

doi:10.1016/j.mce.2019.04.015

Cited by 6 publications

(1 citation statement)

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“…Both isoforms of the pesticide endosulfan, α- and β-endosulfan, were reported to possess xeno-estrogenic potential [ 64 ]. Furthermore, atrophy was noticed in different testicular tissues of male rats fed meal containing 10 ppm concentration of endosulfan [ 65 ]. In another study, it was noted that endosulfan-induced atrophy relates to biochemical changes in testicular tissue that translate into a significant fall in sperm counts in the testicular epididymis region and reduced spermatid counts in intratesticular tissue [ 66 ].…”

Section: Confirmation Of the Pesticide’s Xeno-estrogenicitymentioning

confidence: 99%

Xeno-Estrogenic Pesticides and the Risk of Related Human Cancers

Kumar

Yadav

Banerjee

2022

JoX

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In recent decades, “environmental xenobiotic-mediated endocrine disruption”, especially by xeno-estrogens, has gained a lot of interest from toxicologists and environmental researchers. These estrogen-mimicking chemicals are known to cause various human disorders. Pesticides are the most heavily used harmful xenobiotic chemicals around the world. The estrogen-mimicking potential of the most widely used organochlorine pesticides is well established. However, their effect is not as clearly understood among the plethora of effects these persistent xenobiotics are known to pose on our physiological system. Estrogens are one of the principal risk modifiers of various disorders, including cancer, not only in women but in men as well. Despite the ban on these xenobiotics in some parts of the world, humans are still at apparent risk of exposure to these harmful chemicals as they are still widely persistent and likely to stay in our environment for a long time owing to their high chemical stability. The present work intends to understand how these harmful chemicals may affect the risk of the development of estrogen-mediated human cancer.

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Section: Confirmation Of the Pesticide’s Xeno-estrogenicitymentioning

confidence: 99%