BACKGROUND:In India, locally advanced breast cancer (LABC) is responsible for 30 - 35% of all breast
cancer cases. The purpose of preoperative chemotherapy is that it is capable of shrinking large primary
tumors rendering many inoperable patients operable
METHODS: 2 2
The doses of the drugs used were Cyclophosphamide - 600 mg/m IV infusion, Adriamycin - 50 mg/m IV infusion
2
and 5 uorouracil (FU) - 600 mg/m IV infusion. Clinical response was noted after 3 weeks of third cycle of NACT which was
assessed according to RECIST criteria
RESULTS: 78.1% of our patients responded to NACT (cCR + cPR) with pCR in 17.2% of patients. percentage of complete
response was higher for patients in stage IIIA than for the patient in stage IIIB
CONCLUSION: neo-adjuvant chemotherapy integrated into a multi-modality program is the standard management in patients
with locally advanced breast carcinoma. The patients with pathological complete response and patients without axillary lymph
node were associated with improved outcome after neo adjuvant chemo therapy