Effect of natural inhibitors of free radical reactions on adrenalin autoxidation

Blood serum was from 12-month-old Wistar rats with experimental myocardial infarction caused by occlusion of the upper third of the left coronary artery was analyzed. The content of conjugated dienes by the 45th day after primary experimental myocardial infarction returned to normal and did not differ from that in intact animals of the same age group. MDA concentration in rats of the treatment group was lower compared to normal. It was demonstrated that normalization of LPO was accompanied by significant exhaustion of the endogenous antioxidant system (SOD and catalase). Our results suggest that special therapy is required for correction of the endogenous antioxidant defense system.

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“…The function of the antioxidant system was evalua ted from activities of antioxidant enzymes catalase [5] and SOD [4].…”

Section: Methodsmentioning

confidence: 99%

Lipid peroxidation during cardiac remodeling in 12-month-old rats with experimental infarction

2011

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“…Activity of LPO processes in liver homogenate was evaluated by the content of TBA-reactive products. Activities of catalase and SOD were evaluated as described previously [2,6], protein concentration was measured by the method of Lowry. Morphology of the liver was studied by light microscopy after hematoxylin and eosin staining.…”

Section: Methodsmentioning

confidence: 99%

Activity of Sphingomyelinase in Rat Liver in Acute and Chronic Toxic Hepatitis: Proportion between Peroxidative and Phospholipase Pathways of Lipid Bilayer Modification

et al. 2009

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“…The intensity of LPO in blood serum and myocardial tissue was estimated from the contents of conjugated dienes (CD) [3] and malonic dialdehyde [6] and activities of antioxidant enzymes superoxide dismutase [1] and catalase [7].…”

Section: Methodsmentioning

confidence: 99%

Free radical lipid peroxidation during amiodarone therapy for postinfarction cardiosclerosis

Rebrova

Afanasyev

2008

Bull Exp Biol Med

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Postinfarction remodeling of the heart in animals with myocardial infarction was accompanied by activation of lipid peroxidation in myocardial tissue and blood serum and decrease in antioxidant enzyme activity. In animals with postinfarction cardiosclerosis treated with amiodarone, we observed decreased accumulation of lipid peroxidation products and normalization of superoxide dismutase activity.

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Effect of natural inhibitors of free radical reactions on adrenalin autoxidation

Cited by 13 publications

References 9 publications

Lipid peroxidation during cardiac remodeling in 12-month-old rats with experimental infarction

Lipid peroxidation during cardiac remodeling in 12-month-old rats with experimental infarction

Activity of Sphingomyelinase in Rat Liver in Acute and Chronic Toxic Hepatitis: Proportion between Peroxidative and Phospholipase Pathways of Lipid Bilayer Modification

Free radical lipid peroxidation during amiodarone therapy for postinfarction cardiosclerosis

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