Effect of Natural Food Colorings on Immunoglobulin Productionin Vitroby Rat Spleen Lymphocytes

Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni

“…The data of the present study showed that curcumin treatment augmented both IgG and IgG1 responses against both SWAP and SEA. It has been found that curcumin enhances the humoral immune response by increasing IgG production (Kuramoto et al, 1996). The absolute requirement for antibody response in protection against murine and human schistosomiasis has been amply documented (Hoffmann et al, 1999;Jankovic et al, 1999;Dunne and Mountford, 2001).…”

Curcumin Causes the Growth Arrest and Apoptosis of B Cell Lymphoma by Downregulation of egr-1, C-myc, Bcl-XL, NF-κB, and p53

“…Dietary curcumin increased antibody response in rats in vivo (13). In vitro, curcumin enhanced IgM production at low but not high concentrations in rat spleen lymphocytes (14) but it is unclear if the reduction in antibody response is due to direct effects of curcumin on B cells. Recently, it has been demonstrated that curcumin inhibits proliferation of Jurkat T cells (15) and mitogen responses of normal human T cells (16) but its direct effects on B cells have not yet been reported.…”

Analysis of Binding Interaction between the Natural Apocarotenoid Bixin and Human Serum Albumin by Circular Dichroism and Fluorescence Spectroscopy

“…Nowadays, it is also widely applied in food industry and in cosmetics as an effective natural coloring agent [9] [10]. In recent years, several beneficial biological activities of bixin were reported such as free-radical quenching ability [11] [12], regulation of immunoglobulin production [13], and protective effect on radiation-induced genotoxicity [14]. As has been demonstrated by HPLC method, after ingestion, bixin appears in the human serum [15].…”