Abstract:ObjectiveTo investigate the effect of nasal irrigation on the duration of symptoms and nucleic acid conversion in adults infected with the Omicron variant of COVID-19.MethodsThis quasi-experimental study enrolled patients diagnosed with asymptomatic, mild, or moderate Omicron infection at the Shandong Public Health Clinical Center between April 1, 2022 and May 1, 2022. Patients were divided into two groups to receive Lianhua Qingwen granules and traditional Chinese medicine (TCM) prescriptions (conventional gr… Show more
“…The results of the aforementioned studies and the present trial demonstrate that nasal irrigation with hypertonic seawater solution containing algal and herbal natural ingredients may be more effective than normal saline only. Our results are further supported by a recent study investigating the effect of irrigations with 3% hypertonic saline in adults infected with omicron variant of COVID-19 after adjustment for comorbidities, smoking history, lymphocyte count and Ct values of N gene [30]. These authors also reported that nasal irrigations were associated with quicker reductions in their nucleic acid levels compared to the controls, but there was no noticeable change in the duration of their symptoms [30].…”
Nasal irrigation is thought to decrease the viral load present in the nasal cavity. Our aim was to assess the effect of a hypertonic seawater solution [with algal and herbal natural ingredients (Sinomarin®)] on the viral load of nasopharynx in patients hospitalized with severe COVID-19 pneumonia. We conducted a prospective, randomized, controlled trial from June 2022 to December 2022. We allocated 56 patients with COVID-19 pneumonia into two groups (28 in each group)—the hypertonic seawater group [nasal irrigations with a hypertonic seawater solution (Sinomarin®) every 4 h for 16 h per day, for two consecutive days] and the control group (no nasal irrigations). A second nasopharyngeal swab was collected 48 h after the baseline nasopharyngeal swab (8 h after the last wash in the hypertonic seawater group) to estimate the SARS-CoV-2 viral load as determined by cycle threshold (Ct) values. In the hypertonic seawater group, the mean Ct values significantly increased two days after the initial measurement [ΔCt 48−0 h = 3.86 ± 3.03 cycles, p < 0.001 (95%CI: 2.69 to 5.04)]. No significant differences in the Ct values were observed in the control group [ΔCt 48−0 h = −0.14 ± 4.29, p = 0.866 (95%CI: −1.80 to −1.52)]. At follow-up, 17 patients from the hypertonic seawater group had negative test results compared to only 9 patients from the control group (p = 0.03). Nasal irrigations with a hypertonic seawater solution containing algal and herbal natural ingredients significantly decreased nasopharyngeal viral load and the detection time of SARS-CoV-2 in the nasal cavity.
“…The results of the aforementioned studies and the present trial demonstrate that nasal irrigation with hypertonic seawater solution containing algal and herbal natural ingredients may be more effective than normal saline only. Our results are further supported by a recent study investigating the effect of irrigations with 3% hypertonic saline in adults infected with omicron variant of COVID-19 after adjustment for comorbidities, smoking history, lymphocyte count and Ct values of N gene [30]. These authors also reported that nasal irrigations were associated with quicker reductions in their nucleic acid levels compared to the controls, but there was no noticeable change in the duration of their symptoms [30].…”
Nasal irrigation is thought to decrease the viral load present in the nasal cavity. Our aim was to assess the effect of a hypertonic seawater solution [with algal and herbal natural ingredients (Sinomarin®)] on the viral load of nasopharynx in patients hospitalized with severe COVID-19 pneumonia. We conducted a prospective, randomized, controlled trial from June 2022 to December 2022. We allocated 56 patients with COVID-19 pneumonia into two groups (28 in each group)—the hypertonic seawater group [nasal irrigations with a hypertonic seawater solution (Sinomarin®) every 4 h for 16 h per day, for two consecutive days] and the control group (no nasal irrigations). A second nasopharyngeal swab was collected 48 h after the baseline nasopharyngeal swab (8 h after the last wash in the hypertonic seawater group) to estimate the SARS-CoV-2 viral load as determined by cycle threshold (Ct) values. In the hypertonic seawater group, the mean Ct values significantly increased two days after the initial measurement [ΔCt 48−0 h = 3.86 ± 3.03 cycles, p < 0.001 (95%CI: 2.69 to 5.04)]. No significant differences in the Ct values were observed in the control group [ΔCt 48−0 h = −0.14 ± 4.29, p = 0.866 (95%CI: −1.80 to −1.52)]. At follow-up, 17 patients from the hypertonic seawater group had negative test results compared to only 9 patients from the control group (p = 0.03). Nasal irrigations with a hypertonic seawater solution containing algal and herbal natural ingredients significantly decreased nasopharyngeal viral load and the detection time of SARS-CoV-2 in the nasal cavity.
“…Some studies have demonstrated that nasal irrigation reduces the time to viral clearance and alleviates local symptoms in COVID-19 ( 6 , 12 , 13 ). However, controversy continues as to its effectiveness in relieving systemic symptoms ( 7 , 14 ). NPC patients require saline nasal irrigation during radiation therapy.…”
Section: Discussionmentioning
confidence: 99%
“…Chalageri et al noted the potential of nasal irrigation in reducing the time to viral clearance and alleviating local symptoms in COVID-19 ( 6 ). However, in terms of improving systemic symptoms, a recent study on the omicron variant of COVID-19 reported conflicting results ( 7 ). Thus, while nasal irrigation may have a role in treatment and self-care after COVID-19 infection, further research is required.…”
Background
Coronavirus disease 2019 (COVID-19) has placed a tremendous burden on the world’s healthcare systems, prompting medical professionals worldwide to diligently research and experiment with treatment methods to prevent infection and alleviate symptoms. Previous studies have shown the potential of nasal irrigation in reducing viral clearance time and alleviating local symptoms of COVID-19. However, views differ regarding its efficacy in improving systemic symptoms. Thus, we sought to examine whether saline nasal irrigation might play a role in treatment and self-care after COVID-19 infection, but further validation is still necessary.
Methods
We conducted a retrospective analysis of 468 patients and 51 healthcare personnel concurrently. The participants were grouped based on whether they received saline nasal irrigation. We used χ
2
tests and Fisher’s exact tests to assess the differences in the rates of COVID-19 infection and the rates of developing a fever after COVID-19 infection among different groups. Additionally, we used independent samples
t
-tests and Mann-Whitney U tests to evaluate differences in the maximum fever temperature and fever duration among participants with fever in different groups.
Results
The rate of developing a fever after COVID-19 infection was lower (37.7%) in the patients who underwent saline nasal irrigation. Among all febrile patients, there was no difference in the highest fever temperature, but patients who underwent saline nasal irrigation had a shorter fever duration (1.72±1.05 days). Additionally, the rate of COVID-19 infection and the rate of developing a fever were higher, and fever symptoms were more severe in the healthcare worker group than in the patient group.
Conclusions
Saline nasal irrigation can alleviate symptoms caused by COVID-19 infection.
“…First identified in South Africa on November 9, 2021, the Omicron variant has emerged as the sole current variant of concern. Notably, the Omicron variant demonstrates a transmission capacity 3–4 times higher than that of the delta variant, contributing to its rapid global spread and prevalence [ 35 ].…”
Section: Sars-cov-2 Spike Glycoprotein and Mutations Affecting Its Bi...mentioning
confidence: 99%
“…1 ). Evidence has shown that this type of variant in some subjects causes more serious complications for young people, necessitating adjustments to health protocols to a certain extent [ 35 , 36 ]. Fig.…”
Section: Sars-cov-2 Spike Glycoprotein and Mutations Affecting Its Bi...mentioning
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