A Hypertonic Seawater Nasal Irrigation Solution Containing Algal and Herbal Natural Ingredients Reduces Viral Load and SARS-CoV-2 Detection Time in the Nasal Cavity

Pantazopoulos, Ioannis; Chalkias, Athanasios; Miziou, Angeliki; Spanos, Michalis; Gerovasileiou, Efrosyni; Rouka, Erasmia; Gourgoulianis, Konstantinos

doi:10.3390/jpm13071093

Cited by 4 publications

(3 citation statements)

References 37 publications

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“… 17 Another study showed that nasal irrigation with 2.3 per cent solution, enriched with brown algae and blue-green algae extracts as well as essential oils of Eucalyptus globulus , Mentha spicata and Thymus vulgaris extracts is a safe and effective method for reducing symptoms of acute viral rhinosinusitis, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 18 , 19 This confirmed a previous strategy of successfully using nasal douching solutions in reduction of symptoms of acute viral infection of the upper airway. During irrigation of the nasal cavity with saline solutions, viral particles are mechanically removed.…”

Section: Discussionsupporting

confidence: 79%

The effect of nasal douching by hypertonic 2.3 per cent sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment

Perić,

Gaćeša,

Kovačević

et al. 2023

J. Laryngol. Otol.

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Objective To investigate epidermal growth factor, transforming growth factor-α and interleukin-8 production in nasal mucosa irrigated with hypertonic 2.3 per cent solution with algae extracts, in comparison to 0.9 per cent NaCl during the first two weeks after surgery for nasal polyposis, in relation to symptoms and local findings. Methods This prospective study included 20 nasal polyposis patients postoperatively irrigated with hypertonic solution and 20 nasal polyposis patients postoperatively irrigated with isotonic solution. We evaluated nasal symptom score, endoscopic score and mediator levels in nasal secretions before and after irrigation. Results Following treatment, nasal symptom score and endoscopic score were significantly lower in the hypertonic solution group (p = 0.023; p < 0.001, respectively). The increase in the epidermal growth factor and the decrease in the transforming growth factor-α and interleukin-8 concentration were higher in the hypertonic group (p < 0.001 for all mediators). Conclusion Irrigation with a hypertonic solution was found to be more effective than an isotonic solution in nasal mucosa reparation.

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Section: Discussionsupporting

confidence: 79%

The effect of nasal douching by hypertonic 2.3 per cent sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment

Perić,

Gaćeša,

Kovačević

et al. 2023

J. Laryngol. Otol.

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“…However, more research needs to be conducted to determine the correlation between the appropriate temperature and the efficacy of nasal irrigation ( 42 ). There have been investigations conducted on the usage of saline solution in conjunction with other drugs for treating COVID-19 ( 43 , 44 ). Further research needs to be conducted to determine the most effective concentration, temperature, instruments, and positioning of nasal irrigation for the benefit of patients.…”

Section: Discussionmentioning

confidence: 99%

Significance of saline nasalirrigation for COVID-19 infection: observations and reflections from nursing care of nasopharyngeal carcinoma

Yan,

Ding,

et al. 2024

Transl Cancer Res

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Background Coronavirus disease 2019 (COVID-19) has placed a tremendous burden on the world’s healthcare systems, prompting medical professionals worldwide to diligently research and experiment with treatment methods to prevent infection and alleviate symptoms. Previous studies have shown the potential of nasal irrigation in reducing viral clearance time and alleviating local symptoms of COVID-19. However, views differ regarding its efficacy in improving systemic symptoms. Thus, we sought to examine whether saline nasal irrigation might play a role in treatment and self-care after COVID-19 infection, but further validation is still necessary. Methods We conducted a retrospective analysis of 468 patients and 51 healthcare personnel concurrently. The participants were grouped based on whether they received saline nasal irrigation. We used χ 2 tests and Fisher’s exact tests to assess the differences in the rates of COVID-19 infection and the rates of developing a fever after COVID-19 infection among different groups. Additionally, we used independent samples t -tests and Mann-Whitney U tests to evaluate differences in the maximum fever temperature and fever duration among participants with fever in different groups. Results The rate of developing a fever after COVID-19 infection was lower (37.7%) in the patients who underwent saline nasal irrigation. Among all febrile patients, there was no difference in the highest fever temperature, but patients who underwent saline nasal irrigation had a shorter fever duration (1.72±1.05 days). Additionally, the rate of COVID-19 infection and the rate of developing a fever were higher, and fever symptoms were more severe in the healthcare worker group than in the patient group. Conclusions Saline nasal irrigation can alleviate symptoms caused by COVID-19 infection.

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“…Figure 10. Random effects meta-analysis for all RCTs about alkalinization in COVID-19 [119][120][121][122][123][124][125][126]. This plot shows pooled effects, see the specific outcome analyses for individual outcomes, and the heterogeneity section [21] for discussion.…”

Section: Nose/oropharyngeal Treatmentsmentioning

confidence: 99%

Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review

Donzelli

2023

Preprint

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The official recommendations to manage COVID-19 in the outpatient setting focus on high-cost drugs (remdesivir, nirmatrelvir-ritonavir, molnupiravir), suffering from many problems. Therefore, one may consider also other treatments meeting these criteria: • promising effectiveness, based on favorable randomized controlled trials (RCTs) of sufficient validity. Even without definitive evidence, physicians and informed patients can consider them if they are also: • safe, to the state of knowledge • with a very favorable opportunity cost • biologically plausible/not implausible • accessible • without major commercial sponsors in the trials promoting them, and with researchers without major conflicts of interests. The main focus is on a limited group of functional foods and some their active ingredients, with further mention of other substances of different origin, yet fully meeting all the aforementioned criteria. The functional foods and substances described and discussed certainly do not cover all the known effective therapies for COVID-19 (in one case also for Long-COVID), but the only therapies proposed in this paper currently satisfy all the above criteria. The supporting scientific evidence will favor meta-analyses of RCTs that include the most definitive outcome: all-cause mortality, i.e. the outcome that most fully informed people tend to prioritize. Furthermore, the reported evidence favors clinical studies of the most valid design, i.e. RCTs.

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A Hypertonic Seawater Nasal Irrigation Solution Containing Algal and Herbal Natural Ingredients Reduces Viral Load and SARS-CoV-2 Detection Time in the Nasal Cavity

Cited by 4 publications

References 37 publications

The effect of nasal douching by hypertonic 2.3 per cent sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment

The effect of nasal douching by hypertonic 2.3 per cent sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment

Significance of saline nasalirrigation for COVID-19 infection: observations and reflections from nursing care of nasopharyngeal carcinoma

Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review

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