Effect of Narcotic Analgesics on the Ultrastructure of the Eyeball (Experimental Study)

Pidvalna, Uliana; Kost, Andriy; Матешук-Вацеба, Л. Р.

doi:10.1055/s-0038-1676543

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…The study of microscopic and electron microscopic level revealed the pattern of primary lesion of the vascular component. This prompted the study of angioarchitectonics to evaluate the microcirculatory bed [7,14].…”

Section: Discussionmentioning

confidence: 99%

Morphometric study of angioarchitectonic under the effect of opioid (experimental study)

2020

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Opioids are potent drugs that are widely used to combat pain in severe wounds and in cancer patients. The professional literature provides a limited amount of data on the morphometric analysis of the links of the hemomicrocirculatory bed of the cerebellar cortex and choroid of the eyeball under the influence of an opioid in the experiment. The aim of the work was to establish the features and conduct morphometric studies of the links of the hemomicrocirculatory bed of the cerebellar cortex and choroid in normal conditions and under conditions of 6-week exposure to an opioid in the experiment. The experimental study was carried out on 24 male white rats, 3 months old and weighing 160-180 g. The material for the study is represented by preparations of the choroid and cerebellum with an injected vascular bed. Compared with the control group of animals, profound destructive changes in the angioarchitectonics of the choroid and cerebellar cortex were found under the influence of Nalbuphine. The capillary component is destroyed, the arterioles are tortuous, sclerosed, their lumen is uneven, the wall is thickened, the venules are dilated and deformed. A decrease in comparison with the norm in the diameter of arterioles, the density of the network of exchange vessels, arterio-venular coefficient, as well as an increase in the diameter of venules and an indicator of trophic activity of the tissue. Expansion of arterio-venular anastomoses indicates the discharge of blood from the arterioles into the venous bed, bypassing the destroyed capillaries. A pronounced relationship was established between the depth of structural transformations of the hemomicrocirculatory bed of the cerebellar cortex, choroid of the white rat’s eye and morphometric parameters. It has been confirmed that the triggering mechanism of destructive changes under the influence of narcotic analgesics is the development of angiopathy.

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Section: Discussionmentioning

confidence: 99%

Morphometric study of angioarchitectonic under the effect of opioid (experimental study)

2020

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“…To date, a considerable number of experimental studies have been conducted on the feasibility and effectiveness of narcotic analgesics and their destructive effects on organs and systems [15,16,17]. There is also no consensus in the current literature on the timing of use and the occurrence of irreversible changes [18,19,20,21].…”

Section: морфологія / Morphologymentioning

confidence: 99%

“…На сьогоднішній день проведена чимала кількість експериментальних досліджень щодо доцільності та ефективності застосування наркотичних анальгетиків, про руйнівний вплив на органи та системи [15,16,17]. У сучасній літературі також немає єдиної думки щодо термінів застосування та виникнення незворотних змін [18,19,20,21].…”

Section: мета дослідженняunclassified

Morphometric Analysis of Changes of the Mucosa of Uterine Tube of Female Rat Under the Influence of Opioid in Experiment

Podoliuk,

Hresko,

Bekesevych

et al. 2023

VPBM

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Вісник проблем біології і медицини -2023 -Вип. 4 (171) / Bulletin of problems in biology and medicine -2023 -Issue 4 (171) 360 МОРФОЛОГІЯ / MORPHOLOGYincreased to 231.85±18.3 μm, which we also considered a negative effect of cadmium on vascular liver parenchyma system. Compared to the control, the difference in the diameter of the central lobular vein was significant (р≤0.001).Conclusions. Chronic exposure to cadmium chloride at a dose of 2.0 mg/kg led to changes in the morphological structure of the liver of experimental animals, which was manifested by a significant increase in the thickness of the liver capsule, an increase in the diameter of blood vessels with local hemorrhages in the parenchyma of the organ (on the 30th day of the experiment), an increase in the number connective tissue elements and parenchyma compaction in an experiment on rats. Chronic administration of cadmium chloride to rats leads to an increase in the activity of aspartate aminotransferase and alanine aminotransferase in the blood of male rats compared to the control group at both time points of the study, which was confirmed by the calculation of the de Ritis coefficient and indicates the negative effect of cadmium on the histogenesis of the liver of experimental animals.

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“…

It is known that opioids are effective drugs in the symptomatic treatment of chronic pain of various etiologies, but have a toxic effect with prolonged use [4,17,19]. Current issues for now are the study of morphofunctional changes in various organs under the influence of opioids [9,14,20]. Currently, there are works that highlight the changes in the biochemical parameters of the blood when using narcotic analgesics in the experiment [10,13].

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confidence: 99%

Biochemical parameters of blood and urine of rats at six-week administration of Nalbuphine

Vilkhova

2021

Rep. of Morph.

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Given the widespread use in medicine of opioid analgesics, today it is extremely important to study the morphofunctional changes of various organs with prolonged exposure to opioids. In the modern scientific literature there are works in which changes of biochemical indicators of blood at use of narcotic analgesics in experiment are covered. To study the changes in the biochemical parameters of blood and urine with long-term use of Nalbuphine is an important area of research. The aim of the study was to detect changes in some biochemical parameters of blood and urine of rats at six-week administration of therapeutic doses of Nalbuphine. The study was based on 40 white adult male rats weighing 180-260 g, which were injected daily for six weeks with Nalbuphine injection 20 mg daily, intramuscularly in therapeutic doses. Daily diuresis and creatinine content were determined in urine samples. The content of total protein, creatinine, urea, calcium and phosphorus was determined in blood samples. The glomerular filtration rate was also determined by the clearance of endogenous creatinine. All statistical calculations were performed using R Studio v.1.1.442 and R Commander v.2.4-4 software. The results of the study showed that six weeks of therapeutic doses of Nalbuphine affects the filtration and reabsorption function of the kidney. The use of Nalbuphine for two weeks does not cause significant changes in biochemical parameters, but the established deviations may indicate the first signs of renal dysfunction. Further use of Nalbuphine, including the end of the sixth week of the experiment, leads to significant changes in the filtration and reabsorption functions of the kidneys, as evidenced by statistically significant changes in the biochemical parameters of blood and urine of rats. The data of the study can be used to compare with changes in the functional state of the kidneys caused by prolonged use of Nalbuphine, its withdrawal and the use of other drugs in combination with Nalbuphine. It is also advisable to compare the results of the study with the morphological changes of the kidneys at different times of use of Nalbuphine.

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Effect of Narcotic Analgesics on the Ultrastructure of the Eyeball (Experimental Study)

Cited by 7 publications

References 9 publications

Morphometric study of angioarchitectonic under the effect of opioid (experimental study)

Morphometric study of angioarchitectonic under the effect of opioid (experimental study)

Morphometric Analysis of Changes of the Mucosa of Uterine Tube of Female Rat Under the Influence of Opioid in Experiment

Biochemical parameters of blood and urine of rats at six-week administration of Nalbuphine

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