2015
DOI: 10.1166/jnn.2015.9729
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Effect of Nanoparticle Surface Chemistry on Adsorption and Fluid Phase Partitioning in Aqueous/Toluene and Cellular Systems

Abstract: Copolymers of di(ethylene glycol) methyl ether methacrylate (x = MeO2MA) and oligo(ethylene glycol) methyl ether methacrylate (y = OEGMA) display lower critical solution phenomena in aqueous systems that are tunable by the copolymer ratio (x:y), ionic strength, and temperature. These properties enable tuning the hydrophobicity of macromolecular systems by variation of (x:y). For nanoparticles stabilized with these macromolecules, this provides a systematic approach to understanding the impact of surface chemis… Show more

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Cited by 5 publications
(9 citation statements)
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“…Here, we utilize similar copolymer ratios (5–10% OEGMA) to elicit distinct AgNP surface hydrophobicity at a physiological temperature of 37°C. The OEGMA unit is less hydrophobic than MeO 2 MA; therefore, both increasing LCST and hydrophilicity are correlated to increased OEGMA content in the copolymer composition. Figure illustrates the temperature dependent effects of ( x:y ) ratio on poly(MeO 2 MA x ‐ co ‐OEGMA y ) hydrophobicity and Ag‐(MeO 2 MA x ‐ co ‐OEGMA y ) behavior at 37°C.…”
Section: Resultsmentioning
confidence: 99%
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“…Here, we utilize similar copolymer ratios (5–10% OEGMA) to elicit distinct AgNP surface hydrophobicity at a physiological temperature of 37°C. The OEGMA unit is less hydrophobic than MeO 2 MA; therefore, both increasing LCST and hydrophilicity are correlated to increased OEGMA content in the copolymer composition. Figure illustrates the temperature dependent effects of ( x:y ) ratio on poly(MeO 2 MA x ‐ co ‐OEGMA y ) hydrophobicity and Ag‐(MeO 2 MA x ‐ co ‐OEGMA y ) behavior at 37°C.…”
Section: Resultsmentioning
confidence: 99%
“…36 To provide a preliminary assessment of the effects of variable (x:y) ratio on cell-NP interactions, we also showed that Au-(MeO 2 MA x -co-OEGMA y ) were preferentially internalized by fibroblasts when the copolymer composition was rich in the more hydrophobic (MeO 2 MA) unit. 36 Collectively, these studies have extensively characterized the effects of modulating NP surface properties, specifically hydrophobicity, with variable copolymer composition on NP aggregation kinetics and transport phenomena; however, the fate and functionality of poly(MeO 2 MA x -co-OEGMA y ) coated NP in biological systems is largely unexplored.…”
Section: Introductionmentioning
confidence: 85%
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“…We showed that incremental increases in the hydrophilic OEGMA monomer led to consistently lower contact angles, while there were no observed differences in surface morphology or brush height. To provide a preliminary assessment of the impact of composition‐dependent wettability on cell function, we showed that increased OEGMA content correlated with decreased initial cell attachment after 6 h. In another study, we grafted poly(MEO 2 MA‐co‐OEGMA) to gold nanoparticles and showed that increased OEGMA content elicited decreased cellular uptake . Together, these studies suggest an important role for composition‐dependent surface properties in governing cellular interactions with poly(MEO 2 MA‐co‐OEGMA); however, the cellular responses to poly(MEO 2 MA‐co‐OEGMA)‐based cell culture substrates remain limited.…”
Section: Introductionmentioning
confidence: 98%