One-pot synthesis and characterization of ovalbumin-conjugated gold nanoparticles: A comparative study of adjuvanticity against the physical mixture of ovalbumin and gold nanoparticles

Yang, Yuhua; Zhang, Yibang; Thakur, Aneesh; Li, Ruyan; Han, Xu; Wang, Zhixin; Ghavami, Mahdi; Tu, Zhigang; Liu, Hanqing

doi:10.1016/j.ijpharm.2019.118704

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Cited by 12 publications

(1 citation statement)

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“…[5][6][7] Gold nanoparticles (AuNPs) have been used as adjuvants in some recent research and are an area of development in immunology applications. 8,9 Studies suggest that AuNPs can enhance B cell responses in antibody production 8,10 and cytotoxic T cell responses. 11,12 For example, a formulation of AuNPs conjugated to ovalbumin (OVA) generated specic immunoglobulin G (IgG) for the antigen.…”

Section: Introductionmentioning

confidence: 99%

In silico description of the adsorption of cell signaling pathway proteins ovalbumin, glutathione, LC3, TLR4, ASC PYCARD, PI3K and NF-Kβ on 7.0 nm gold nanoparticles: obtaining their Lennard-Jones-like potentials through docking and molecular mechanics

Coelho,

Bezerra,

da Costa

et al. 2023

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

In silico description of the adsorption of cell signaling pathway proteins ovalbumin, glutathione, LC3, TLR4, ASC PYCARD, PI3K and NF-Kβ on 7.0 nm gold nanoparticles: obtaining their Lennard-Jones-like potentials through docking and molecular mechanics

Coelho,

Bezerra,

da Costa

et al. 2023

RSC Adv.

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Bioactive Compounds

Visentini¹,

Pérez²,

Ferrado³

et al. 2022

Biomolecules From Natural Sources

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Recent Advances in Nanotechnology‐Mediated Noninvasive Transdermal and Topical Delivery of Proteins

Ko,

Kim,

Choi

et al. 2024

Small Science

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Protein therapeutics are emerging as essential technologies due to their functional and chemical properties. However, their application is currently limited to delivery by oral and injection methods—the former being inefficient and the latter invasive and potentially tissue damaging. Researchers are, therefore, exploring noninvasive delivery systems for proteins through the skin, including transdermal and topical delivery. The large molecular size of proteins presents a key challenge for skin penetration, hindering their ability to penetrate the dense skin lamellar structure. This review focuses on using nanoparticles as carriers to increase protein stability and enhance skin penetration. The use of noninvasive or minimally invasive enhancers for controlling and improving penetration depth is also examined. Furthermore, the physical properties of nanoparticles that affect delivery are evaluated, aiming to propose ways to advance transdermal and topical delivery methods in the future.

show abstract

One-pot synthesis and characterization of ovalbumin-conjugated gold nanoparticles: A comparative study of adjuvanticity against the physical mixture of ovalbumin and gold nanoparticles

Cited by 12 publications

References 59 publications

In silico description of the adsorption of cell signaling pathway proteins ovalbumin, glutathione, LC3, TLR4, ASC PYCARD, PI3K and NF-Kβ on 7.0 nm gold nanoparticles: obtaining their Lennard-Jones-like potentials through docking and molecular mechanics

In silico description of the adsorption of cell signaling pathway proteins ovalbumin, glutathione, LC3, TLR4, ASC PYCARD, PI3K and NF-Kβ on 7.0 nm gold nanoparticles: obtaining their Lennard-Jones-like potentials through docking and molecular mechanics

Bioactive Compounds

Recent Advances in Nanotechnology‐Mediated Noninvasive Transdermal and Topical Delivery of Proteins

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