Effect of nanoparticle encapsulation on the photostability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate

Perugini, Paola; Simeoni, Silvia; Scalia, Santo; Genta, Ida; Modena, Tiziana; Conti, Bice; Pavanetto, F

doi:10.1016/s0378-5173(02)00356-3

Cited by 151 publications

(87 citation statements)

References 15 publications

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“…19 An important advantage of these systems is their small size (below 1 mm), which facilitates their formulation in dermatological products and enables comfortable application to the skin. 19,20 Besides, the possibility of increasing the effectiveness and stability of formulations or active substances, as well as their gradual release in adequate doses are good advantages too. 21,22 This way, this work aims to propose a strategy to prepare nanoemulsions and polymeric nanocapsules formulations using TTO as oily phase due its interesting properties for topical application.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured systems containing an essential oil: protection against volatilization

Flôres¹,

Ribeiro²,

Ourique³

et al. 2011

Quím. Nova

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Recebido em 19/8/10; aceito em 22/12/10; publicado na web em 25/3/11The goal of this study was to evaluate the feasibility of preparing nanocapsules and nanoemulsions using tea tree oil as oily phase aiming to protect its volatilization. The nanostructures presented nanometric mean size (160-220 nm) with a polydispersity index below 0.25 and negative zeta potential. The pH values were 6.43 ± 0.37 and 5.98 ± 0.00 for nanoemulsions and nanocapsules, respectively. The oil content after preparation was 96%. The inclusion of tea tree oil in nanocapsules showed higher protection against volatilization. The analysis of mean size and polydispersity index of formulations presented no significant alteration during the storage time.

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Section: Introductionmentioning

confidence: 99%

Nanostructured systems containing an essential oil: protection against volatilization

Flôres¹,

Ribeiro²,

Ourique³

et al. 2011

Quím. Nova

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“…In cosmetic preparations TiO 2 is coated to reduce photocatalytic activity. Recent studies verify a suffi cient stability of coated titanium microparticles used in sunscreens with regard to penetration and mechanical abrasion simulating in-use conditions of sunscreens [12] . In view of toxic effects of TiO 2 to cellular components, one has to say that on the one hand it does not penetrate the stratum corneum in viable skin.…”

Section: Inorganic Sunscreensmentioning

confidence: 88%

Sunscreens – Which and What for?

Maier

Körting²

2005

Skin Pharmacol Physiol

123

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micronization and encapsulation allow the development of high-quality inorganic sunscreens. The potential systemic toxicity of organic sunscreens has lately primarily been discussed controversially in public, and several studies show contradictory results. Although a matter of debate, at present the sun protection factor (SPF) is the most reliable information for the consumer as a measure of sunscreen fi lter effi cacy. In this context additional tests have been introduced for the evaluation of not only the protective effect against erythema but also protection against UV-induced immunological and mutational effects. Recently, combinations of UV fi lters with agents active in DNA repair have been introduced in order to improve photoprotection. This article reviews the efficacy of sunscreens in the prevention of epithelial and nonepithelial skin cancer, the effect on immunosuppression and the value of the SPF as well as new developments on the sunscreen market.

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“…Characterization and Evaluation Studies: Morphology: The usnic acid loaded nanoparticles were subjected to scanning Electron Microscope (SEM) for determining its size and shape. The nanoparticle size and shape were to be characterized and photographed 17 .…”

Section: Methods Of Preparationmentioning

confidence: 99%

Untitled

2017

IJPSR

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Usnic acid is lichen metabolite. Lichen species are the source of usnic acid. It has Antitumor and Anti-proliferation activity. Usnic acid is poorly water soluble drug. So its dissolution and bioavailability is poor. To enhance dissolution and bioavailability of usnic acid nanotechnology has been adopted. So in this study usnic acid powder was formulated as a nanoparticle with the help of PLGA polymer. Nano-precipitation with sonication method was adopted to formulate usnic acid loaded nanoparticles. Obtained nanoparticles were undergone to characterization and evaluation studies. SEM study revealed that particles are in the range of nanometer level and it is in spherical shape. FTIR and DSC studies have shown that no interaction between drug and polymer. In vitro drug release was maximum for optimized formulation. Optimized formulation also exhibited more antitumor activity than free usnic acid. Kinetic study revealed that the drug release is zero order. It concludes nano-precipitation with sonication is effective method for preparation of usnic acid loaded nanoparticles.

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Effect of nanoparticle encapsulation on the photostability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate

Cited by 151 publications

References 15 publications

Nanostructured systems containing an essential oil: protection against volatilization

Nanostructured systems containing an essential oil: protection against volatilization

Sunscreens – Which and What for?

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