Effect of nanofillers on the physico-mechanical properties of load bearing bone implants

Michael, Feven Mattews; Khalid, Mohammad; Walvekar, Rashmi; Ratnam, Chantara Thevy; Ramarad, Suganti; Siddiqui, Humaira; Hoque, Enamul

doi:10.1016/j.msec.2016.05.037

Cited by 84 publications

(24 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the functionalization of the CF and CNTs resulted in uniform dispersion via covalent bonding and provided higher mechanical strength [14,24]. The mechanical properties of cortical and cancellous bones have been reported by Michael et al [25]. However, cortical bone with 5%-30% porosity is denser than cancellous bone with 70%-95% porosity.…”

Section: Mechanical Propertiesmentioning

confidence: 84%

Fabrication and Biological Analysis of Highly Porous PEEK Bionanocomposites Incorporated with Carbon and Hydroxyapatite Nanoparticles for Biological Applications

et al. 2020

View full text Add to dashboard Cite

Bone regeneration for replacing and repairing damaged and defective bones in the human body has attracted much attention over the last decade. In this research, highly porous polyetheretherketone (PEEK)/hydroxyapatite (HA) bionanocomposite scaffolds reinforced with carbon fiber (CF) and carbon nanotubes (CNTs) were fabricated, and their structural, mechanical, and biological properties were studied in detail. Salt porogen (200–500 µm size) leaching methods were adapted to produce porous PEEK structures with controlled pore size and distribution, facilitating greater cellular infiltration and biological integration of PEEK composites within patient tissue. In biological tests, nanocomposites proved to be non-toxic and have very good cell viability. In addition, bone marrow cell growth was observed, and PEEK/HA biocomposites with carbon particles showed increased cell attachment over the neat PEEK/HA composites. In cell viability tests, bionanocomposites with 0.5 wt% CNTs established good attachment of cells on disks compared to neat PEEK/HA biocomposites. A similar performance was seen in culture tests of bone marrow cells (osteoblasts and osteoclasts). The 0.5 wt% CF for osteoblasts and 1 wt% CNTs for osteoclasts showed higher cell attachment. The addition of carbon-based nanomaterials into PEEK/HA has been identified as an effective approach to improve cell attachment as well as mechanical and biological properties. With confirmed cell attachment and sustained viability and proliferation of the fabricated PEEK/HA/CNTs, CF bionanocomposites were confirmed to possess excellent biocompatibility and will have potential uses in bone scaffolding and other biomedical applications.

show abstract

Section: Mechanical Propertiesmentioning

confidence: 84%

Fabrication and Biological Analysis of Highly Porous PEEK Bionanocomposites Incorporated with Carbon and Hydroxyapatite Nanoparticles for Biological Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Paul et al reported that the tensile moduli and ultimate tensile stresses of kenaf‐reinforced polypropylene composites upregulated with increasing fiber mass fraction . To withstand the stresses and loads in the body, the mechanical properties of scaffolds should match those of the host tissue as closely as possible . It is generally considered that if the mechanical properties of scaffolds are more similar to those of natural tissues, then the scaffolds will be more biocompatible and more suitable for cell cultivation .…”

Section: Preparation and Characterizations Of Polymer Fiber Scaffoldsmentioning

confidence: 99%

Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering

Zhang

Liu

Zeng

et al. 2019

Adv Funct Materials

219

154

View full text Add to dashboard Cite

Successful regeneration of weight-bearing bone defects and criticalsized cartilage defects remains a major challenge in clinical orthopedics. In the past decades, biodegradable polymer materials with biomimetic chemical and physical properties have been rapidly developed as ideal candidates for bone and cartilage tissue engineering scaffolds. Due to their unique advantages over other materials of high specific-surface areas, suitable mechanical strength, and tailorable characteristics, scaffolds made of polymer fibers have been increasingly used for the repair of bone and cartilage defects. This Review summarizes the preparation and compositions of polymer fibers, as well as their characteristics. More importantly, the applications of polymer fiber scaffolds with well-designed structures or unique properties in bone, cartilage, and osteochondral tissue engineering have been comprehensively highlighted. On the whole, such a comprehensive summary affords constructive suggestions for the development of polymer fiber scaffolds in bone and cartilage tissue engineering.

show abstract

“…If instead higher stiffness and yield strength materials are needed, for instance in orthopedic applications like bone implants in forms of scaffolds for cellular growth, blends with high PLA and LTI content would be the most suitable materials [24].…”

Section: 2-mechanical Features Of the Blendsmentioning

confidence: 99%

“…It is possible then to make easy drug delivery systems with good drug absorption kinetics [24][25][26][27][28][29] which can also be studied by software modeling and further description [30].…”

Section: Wet-abilitymentioning

confidence: 99%

Effect of Ethyl Ester L-Lysine Triisocyanate addition to produce reactive PLA/PCL bio-polyester blends for biomedical applications

Visco

Nocita

Giamporcaro

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

show abstract

Effect of nanofillers on the physico-mechanical properties of load bearing bone implants

Cited by 84 publications

References 136 publications

Fabrication and Biological Analysis of Highly Porous PEEK Bionanocomposites Incorporated with Carbon and Hydroxyapatite Nanoparticles for Biological Applications

Fabrication and Biological Analysis of Highly Porous PEEK Bionanocomposites Incorporated with Carbon and Hydroxyapatite Nanoparticles for Biological Applications

Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering

Effect of Ethyl Ester L-Lysine Triisocyanate addition to produce reactive PLA/PCL bio-polyester blends for biomedical applications

Contact Info

Product

Resources

About