Effect of nano zinc oxide or chelated zinc as alternatives to medical zinc oxide on growth performance, faecal scores, nutrient digestibility, blood profiles and faecal <i>Escherichia coli</i> and <i>Lactobacillus</i> concentrations in weaned piglets

Oh, Han Jin; Kim, Myung Hoo; Wang, Yun; Lee, Jihwan; An, Jin Yong; Kim, Yong Ju; Kim, Min Ji; Kim, Hyeun bum; Cho, Jin Ho

doi:10.1080/1828051x.2022.2057875

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…In contrast to these results, Barszcz et al [14] demonstrated no effect of dietary zinc supplementation on bacterial population analyses in the large intestine of pigs. Some other existing information illustrates a close relationship between Zn metabolism and gut microbiota [19,36,37]. The frequent high heterogeneity of these findings may be related to the different biological impact of various chemical sources of zinc and, in addition, to the dose-and the hostspecies-specific response of the intestinal bacteria to this microelement [10]; further, the methodology used for bacterial quantification cannot be ignored.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Zinc and/or an Herbal Mixture on Intestinal Microbiota and Barrier Integrity in Lambs

Bujňáková,

Kucková,

Váradyová

et al. 2023

Agriculture

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The purpose of this experiment was to determine the impact of feed supplementation with organic zinc and/or a medicinal plants mixture on the composition and enzymatic activity of intestinal microflora as well as on the duodenal and jejunal barrier integrity in lambs. A total of 28 lambs were randomly allocated into 4 dietary treatments (n = 7) and were fed an unsupplemented basal diet (BD), or the BD enriched with organic Zn (Zn, 70 mg/kg diet), an herbal mixture (Herbmix, 100 g/day) or a combination of both additives (Zn+Herbmix). The Herbmix contained 33% each of Fumaria officinalis, Malva sylvestris, Matricaria chamomilla and 1% Artemisia absinthium. No significant effect on the fecal microbiota composition was observed due to the 35-day or 70-day dietary treatment. The intake of Zn alone resulted in decreased bacterial enzyme activities, such as β-glucuronidase, N-acetyl-glucosaminidase, β-galactosidase and β-glucosidase. The transepithelial electrical resistance of the small intestinal mucosa was not influenced by the dietary treatment, whereas simultaneous feeding of Zn and Herbmix exhibited higher claudin-1 and occludin levels in the jejunal mucosa. These results indicate that dietary intake of organic zinc and/or medicinal plants in the mentioned dosage did not alter the diversity of intestinal bacteria in growing lambs but did significantly influence bacterial enzyme activity. Supplementing the zinc and herbs combination showed the potential to regulate intestinal permeability by increasing the level of tight junction proteins in the jejunal mucosa.

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Section: Discussionmentioning

confidence: 99%

Effects of Dietary Zinc and/or an Herbal Mixture on Intestinal Microbiota and Barrier Integrity in Lambs

Bujňáková,

Kucková,

Váradyová

et al. 2023

Agriculture

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“…The decrease in the abundance of the Clostridium cluster XIV group with Zn supplementation is in contrast with the in vivo results under thermoneutral conditions where weanling piglets fed increasing levels of ZnO (50, 150, 250, 1000 and 2500 mg zinc/kg) had decreased clostridial cluster XIVa at the ileum only at the highest ZnO level [ 66 ], and similarly, lactobacilli, bifidobacterial and enterococci were not affected. Nonetheless, many studies have reported that pharmacological supplementation with Zn in weaning diets could improve the intestinal microbiota [ 65 , 74 , 75 ]. Interestingly, the abundance of the Clostridium cluster XIV group decreased with Zn supplementation.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Supplementation with Betaine and Zinc on In Vitro Large Intestinal Fermentation in Iberian Pigs under Heat Stress

Pardo

Mateos

Saro

et al. 2023

Animals

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We investigated the effects of betaine and zinc on the in vitro fermentation of pigs under heat stress (HS). Twenty-four Iberian pigs (43.4 ± 1.2 kg) under HS (30 °C) were assigned to treatments for 4 weeks: control (unsupplemented), betaine (5 g/kg), and zinc (0.120 g/kg) supplemented diet. Rectal content was used as the inoculum in 24-hincubations with pure substrates (starch, pectin, inulin, cellulose). Total gas, short-chain fatty acid (SCFA), and methane production and ammonia concentration were measured. The abundance of total bacteria and several bacterial groups was assessed. Betaine increased the acetate production with pectin and inulin, butyrate production with starch and inulin, and ammonia concentration, and decreased propionate production with pectin and inulin. The abundance of Bifidobacterium and two groups of Clostridium decreased with betaine supplementation. Zinc decreased the production of SCFA and gas with starch and inulin, associated with diminished bacterial activity. Propionate production decreased with starch, pectin, and inulin while butyrate production increased with inulin, and isoacid production increased with cellulose and inulin in pigs supplemented with zinc. The ammonia concentration increased for all substrates. The Clostridium cluster XIV abundance decreased in pigs fed zinc supplemented diets. The results reported were dependent on the substrate fermented, but the augmented butyrate production with both betaine and zinc could be of benefit for the host.

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“…Alternatives to the use of zinc oxide to prevent diarrhoea in weaner piglets have been investigated in response to these measures. 4,5…”

Section: Introductionmentioning

confidence: 99%

“…Alternatives to the use of zinc oxide to prevent diarrhoea in weaner piglets have been investigated in response to these measures. 4,5 Zinc oxide can also be used as a feed supplement for pigs and other animals to prevent mineral deciencies. Consequently, measured information on the levels of zinc in the environment around agricultural facilities will reect not only the medicinal uses, but also nutritional uses, as well as zinc from other sources such as galvanised steel, atmospheric deposition, and from natural sources.…”

Section: Introductionmentioning

confidence: 99%

Environmental risk assessment of the use of zinc oxide medicated feeds for weaning piglets in the UK

Peters,

Merrington,

Stapleton

et al. 2024

Environ. Sci.: Adv.

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Effect of nano zinc oxide or chelated zinc as alternatives to medical zinc oxide on growth performance, faecal scores, nutrient digestibility, blood profiles and faecal Escherichia coli and Lactobacillus concentrations in weaned piglets

Cited by 6 publications

References 38 publications

Effects of Dietary Zinc and/or an Herbal Mixture on Intestinal Microbiota and Barrier Integrity in Lambs

Effects of Dietary Zinc and/or an Herbal Mixture on Intestinal Microbiota and Barrier Integrity in Lambs

The Effect of Supplementation with Betaine and Zinc on In Vitro Large Intestinal Fermentation in Iberian Pigs under Heat Stress

Environmental risk assessment of the use of zinc oxide medicated feeds for weaning piglets in the UK

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