Effect of Na⁺ and K⁺ on the cucurbituril-mediated hydrolysis of a phenyl acetate

Abstract

The environment around the active site affects the catalytic activity of enzymes. Studying the cucurbit[7]uril promoted acid hydrolysis of a cationic phenyl acetate derivative, we found that hydrophobic cavity of...

A light-gated regulation of the reaction site by a cucurbit[7]uril macrocycle

“…Switching to the neutral spiropyran form (SP, ON state) cancels the electrostatic interaction of the macrocycle with the regulator and allows it to bind a more favorable benzaldehyde station, where it catalyzes the hydrazonation 5 due to the stabilization of protonated reaction species. 6 Details on the synthesis and isomerization behavior of the axle (UV-Vis spectra) can be found in the ESI (pp. S2–S22) †…”