Effect of myrtle fruit syrup on abnormal uterine bleeding: a randomized double-blind, placebo-controlled pilot study

Abstract

BackgroundMyrtle (Myrtus communis L.) has been used in the Iranian Traditional Medicine as a treatment for abnormal uterine bleeding-menometrorrhagia. The main aim of this study is to evaluate the effect of myrtle fruit syrup on abnormal uterine bleeding-menometrorrhagia.MethodsA randomized, double-blind, placebo-controlled pilot study was conducted on 30 women suffering from abnormal uterine bleeding-menometrorrhagia. Treatment comprised of giving 15 ml oral myrtle syrup daily (5 ml three times a day) for 7 days starting from the onset of bleeding. The myrtle syrup along with placebo was repeated for 3 consecutive menstrual periods. Menstrual duration and number of used pads were recorded by the Pictorial Blood loss Assessment Chart at the end of each menstrual period. The quality of life was also evaluated using the menorrhagia questionnaire.ResultsThe mean number of bleeding days significantly declined from 10.6 ± 2.7 days to 8.2 ± 1.9 days after 3 months treatment with the syrup (p = 0.01) and consequently the participants in the intervention group used fewer pads after 3 months (16.4 ± 10.7) compared with the number of pads used at the beginning of the treatment (22.7 ± 12.0, p = 0.01). Bleeding days and number of pads used by the participants in the placebo group did not change significantly. Also significant changes of quality of life scores were observed in the intervention group after 3 months compared to the baseline.ConclusionMyrtle syrup is introduced as a potential remedy for abnormal uterine bleeding-menometrorrhagia.

The Effect of Capsella bursa-pastoris Extract on Heavy Menstrual Bleeding and Quality of Life in Patients with Uterine Leiomyoma: A Double-blind Randomized Clinical Trial

“…The total score of MQ varied from zero to 100 and a lower score means a better quality of life. The validity and reliability of this questionnaire have been confirmed in other studies in Iran [35,36].…”

“…In the past, tyramine and choline were responsible for controlling the bleeding by the plant. Todays, new researches have shown that other substances that are not fully recognized may be responsible for such an effect [25][26][27][28][29][30][31][32][33][34][35][36][37][38]. Anyway, the contractile and hemostatic nature of this drug cannot be ignored.…”

Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

“…Qaraaty et al . () reported a randomized, double‐blind, placebo‐controlled pilot study in Iran conducted on 30 women of reproductive age suffering from AUB‐E. M. communis is a species of the Myrtaceae family known under the Persian name ‘mourd’ or ‘aass’.…”

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“…The results were similar to the findings of this study. In the study carried out by Qaraaty et al, the duration of bleeding and the number of pads used as well as the quality of life score decreased in patients with abnormal uterine bleeding through the prescription of "Myrtle syrup" 30 . In Qaraaty's study, "Myrtle syrup" was taken 7 days every month, but in this study, "Quince paste" was taken for the entire month.…”