Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

Javan, Roghayeh; Yousefi, Mahdi; Nazari, Seyed-Mohammad; Amiri, Parvin; Mosavi‐Jarrahi, Alireza; Modiramani, Parvaneh; Naghedi-Baghdar, Hamideh

doi:10.1002/ptr.5675

Cited by 20 publications

(15 citation statements)

References 36 publications

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“…Although few studies have been conducted on the use of medicinal plants to reduce menstrual bleeding (18,19), there was only one study on the effectiveness of dry cupping as before and after the intervention, with a limited sample size (n = 15) in India. In that study, a significant difference was found between the severity of the bleeding before and after the intervention (20).…”

Section: Discussionmentioning

confidence: 99%

Traditional Dry Cupping Therapy Versus Medroxyprogesterone Acetate in the Treatment of Idiopathic Menorrhagia: A Randomized Controlled Trial

Azizkhani

Dastjerdi

Arani

et al. 2018

Iran Red Crescent Med J

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Background: Dry cupping has been used as a treatment for abnormal uterine bleeding in Iranian traditional medicine. Objectives: The present study aimed at evaluating the usefulness of dry cupping on excessive menstrual blood loss in menorrhagia with a well-validated menstrual pictogram compared to medroxyprogesterone acetate. Methods: A total of 162 women with menorrhagia were enrolled in this prospective, randomized, controlled trial in Iran from 2015 to 2016. Written informed consent was obtained, then, patients were randomly allocated into dry cupping (3 sessions of interrupted and kinetic dry cupping during menstrual bleeding) or medroxyprogesterone acetate (10 mg/day throughout the luteal period) groups using a random number sequence. The number of bleeding days and objective estimation of menstrual blood loss using a pictorial blood loss assessment chart (PBAC) were recorded before the intervention and at specific intervals (1 and 3 months post intervention). Results: At 1 and 3 months, PBAC scores were significantly lower in women treated with cupping compared with women treated with medroxyprogesterone acetate. These reductions in PBAC score were 214.9 mL with 95% CI (120.5 to 309.2) greater than medroxyprogesterone acetate at 1 month and 237.3 with 95% CI (143.0 to 331.7) at 3-month follow-up period. Reduction in the number of bleeding days in the cupping group for almost one day was better than the control groups at 1 and 3 months follow-up (Mean difference:-1.03, 95% CI (-1.78 to -0.26), P = 0.007). Conclusions: Dry cupping is an effective treatment in reducing the intensity of bleeding during menstrual period compared to medroxyprogesterone acetate.

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Section: Discussionmentioning

confidence: 99%

Traditional Dry Cupping Therapy Versus Medroxyprogesterone Acetate in the Treatment of Idiopathic Menorrhagia: A Randomized Controlled Trial

Azizkhani

Dastjerdi

Arani

et al. 2018

Iran Red Crescent Med J

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“…Tannins are considered as astringents 11 and thus can cause the contraction of capillary endothelium and the reduction of uterine bleeding 19 . Flavonoids reduce the synthesis of endometrial prostaglandins and consequently reduce extensive uterine bleeding 20 .…”

Section: Discussionmentioning

confidence: 99%

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2018

IJPSR

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Introduction: Menorrhagia that means excessive uterine bleeding is one the most common reasons that women refer to gynecological centers. Despite the use of "Quince paste" in Iranian Traditional Medicine (ITM) clinics, no studies have been done in this regard. Objectives: This study was carried out to investigate the effect of "Quince paste" on uterine bleeding in patients with menorrhagia. Materials and methods: This study was a clinical trial of before-after pilot study conducted on 35 patients aged 18-50 years suffering from menorrhagia. A tea spoonful of "Quince paste" after each meal was prescribed for two months. A pictorial form was completed to determine bleeding volumes and days as well as quality of life questionnaire before and at the end of the intervention. Results: Patients age was 33.8 ± 10.8 years and BMI was 28.94 ± 14.07. Bleeding score decreased significantly after two months of intervention (from 264.2 ± 198.9 to 125.8±155.9), (p<0.001). Quality of life score decreased significantly from 30.28 ± 5.73 to 22.02 ± 3 (p<0.001). Bleeding days decreased significantly in comparison with the baseline because of the treatment (p<0.001). Conclusion: It seems like that "Quince paste" can reduce the volume and duration of bleeding in patients with menorrhagia and improve their quality of life. It seems that "Quince paste" could be introduced as a treatment for menorrhagia based on ITM. INTRODUCTION:Menorrhagia means excessive bleeding (more than 80 ml of blood) or bleeding or along term (more than or equal to 8 days) that occurs at regular intervals 1 . Menorrhagia is one of the most common gynaecological problems the occurrence of which increases with age. More than 30% of women of child bearing age and 60% of the total women population experience it. This disorder totally forms 12% of the reason for referral to gynecologists.

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“…However, according to a systematic review, further well-designed trials are recommended to investigate the safety and efficacy of herbs in the treatment of women with menorrhagia (22). To the best of our knowledge, no study has so far assessed the effects of quince on menstrual bleeding.…”

Section: Introductionmentioning

confidence: 99%

Effects of Mefenamic Acid Versus Quince on Menorrhagia and Quality of Life: A Randomized Controlled Trial

Rahi

Mirghafourvand

Mohammad‐Alizadeh‐Charandabi

et al. 2017

Iran Red Crescent Med J

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Objectives: To compare the effects of mefenamic acid versus quince on menorrhagia and quality of life. Methods: This randomized controlled trial was conducted on women with menorrhagia. The participants were allocated into 2 groups through block randomization. The first group (n, 72) received quince pills, while the second group (n, 74) used mefenamic acid pills for 3 consecutive cycles. The participants completed the pictorial blood loss assessment chart (PBAC) before and during the intervention. Moreover, the short-form health survey (SF-36) was completed before and 3 months after the intervention. Results: The mean PBAC scores decreased significantly in both groups. The mean PBAC score in the quince group decreased from 173.6 (SD, 53.8) before the intervention to 116.7 (51.7), 86.4 (43.1), and 68.9 (36.4), respectively in the first, second, and third months after the intervention. The mean PBAC scores in the mefenamic acid group was 176.8 (54.3) at baseline and 106.6 (50.40), 81.6 (38.7), and 63.8 (33.8), respectively in the first, second, and third months after the intervention. There was no significant difference between the groups in terms of the mean PBAC score (P = 0.183). Similarly, after the intervention, there was no significant difference between the groups in terms of physical health (P = 0.476) and mental health (P = 0.572) components of quality of life. Conclusions: Quince pills were as effective as mefenamic acid pills in reducing the intensity of menstrual bleeding. Therefore, they seem to be a proper alternative for mefenamic acid.

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Herbal Medicines in Idiopathic Heavy Menstrual Bleeding: A Systematic Review

Cited by 20 publications

References 36 publications

Traditional Dry Cupping Therapy Versus Medroxyprogesterone Acetate in the Treatment of Idiopathic Menorrhagia: A Randomized Controlled Trial

Traditional Dry Cupping Therapy Versus Medroxyprogesterone Acetate in the Treatment of Idiopathic Menorrhagia: A Randomized Controlled Trial

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Effects of Mefenamic Acid Versus Quince on Menorrhagia and Quality of Life: A Randomized Controlled Trial

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