Effect of myopic LASIK on human corneal sensitivity1 1The authors have no financial or proprietary interest related to any methods or materials described herein.

Nassaralla, Belquiz; McLeod, Stephen D.; Nassaralla, JJ

doi:10.1016/s0161-6420(02)01897-3

Cited by 54 publications

(10 citation statements)

References 13 publications

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“…It is well known that LASIK, despite its positive attributes in keratorefractive surgery, can induce dry eye syndrome in some patients (Aras et al 2000; Battat et al 2001; Toda et al 2001; Nassaralla et al 2003). Dry eye in patients that underwent LASIK seems to be a result of multifactorial processes such as decreased corneal sensation or alteration ocular surface and lacrimal gland function (Heigle and Plugfelder 1996; Linna et al 2000; Stern et al 2000).…”

Section: Resultsmentioning

confidence: 99%

Treatment of chronic dry eye: focus on cyclosporine

Kymionis

Bouzoukis²,

Diakonis³

et al. 2008

OPTH

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To review the current treatment of chronic dry eye syndrome, focusing on cyclosporine A (CsA), a systematic literature search was performed using PubMed databases in two steps. The first step was oriented to articles published for dry eye. The second step was focused on the use of CsA in dry eye. A manual literature search was also undertaken based on citations in the published articles. The knowledge on the pathogenesis of dry eye syndrome has changed dramatically during the last few years. Inflammation and the interruption of the inflammatory cascade seem to be the main focus of the ophthalmologic community in the treatment of dry eye, giving the anti-inflammatory therapy a new critical role. The infiltration of T-cells in the conjuctiva tissue and the presence of cytokines and proteasis in the tear fluid were the main reason introducing the use of immunomodulator agents such as corticosteroids, cyclosporine, and doxycicline in order to treat dry eye syndrome. CsA emulsion is approved by the FDA for the treatment of dry eye, while clinical trials of this agent have demonstrated efficacy and safety of CsA. CsA seems to be a promising treatment against dry eye disease. New agents focused on the inflammatory pathogenesis of this syndrome in combination with CsA may be the future in the quest of treating dry eye. More studies are needed to determine the efficacy, safety, timing, and relative cost/effect of CsA.

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Section: Resultsmentioning

confidence: 99%

Treatment of chronic dry eye: focus on cyclosporine

Kymionis

Bouzoukis²,

Diakonis³

et al. 2008

OPTH

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“…Perez-Santonja et al showed that after LASIK it takes at least 6 months for full recovery of corneal sensitivity, which was also confirmed by Nassaralla et al [1,14]. Erie et al showed that following LASIK, sub-basal nerve density is reduced by 51%, 35%, and 34% at 1, 2, and 3 years respectively, compared to preoperative levels (P<0.001), with full recovery at 5 years after surgery [15].…”

Section: Discussionmentioning

confidence: 81%

“…The most central corneal area (point 5) demonstrated the greatest difference in corneal sensitivity compared to control (P<0.05). The center of the cornea (point 5) has the slowest and lowest relative recovery rate according to numerous studies [1,14,25,26]; thus, the fact that the greatest difference was observed in the central corneal area is an important finding. At point 4, which is nearer to the hinge, a still significant but less striking improvement than point 5 was observed.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of transcutaneous electrical simulation to improve recovery from corneal hypoesthesia after LASIK

Ghaffariyeh

Peyman

Puyan

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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“…Ablation depth and higher myopic refractive corrections positively correlate with decreased corneal sensitivity, 34,35 with increased likelihood of developing immediate postoperative dry eye symptoms, 16 and with increased likelihood of developing chronic tear dysfunction. 36,37 Higher refractive corrections and deeper ablations likely damage deeper stromal nerves and destroy more neural tissue, leading to delayed regeneration of the subepithelial nerve plexus.…”

Section: Ocular Surface Abnormalities Found After Lasikmentioning

confidence: 93%

Post-LASIK Tear Dysfunction and Dysesthesia

2010

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Symptoms of tear dysfunction after laser in situ keratomileusis (LASIK) occur in nearly all patients and resolve in the vast majority. Although dry eye complaints are a leading cause of patient discomfort and dissatisfaction after LASIK, the symptoms are not uniform, and the disease is not a single entity. Post-LASIK tear dysfunction syndrome or dry eye is a term used to describe a spectrum of disease encompassing transient or persistent post-operative neurotrophic disease, tear instability, true aqueous tear deficiency, and neuropathic pain states. Neural changes in the cornea and neuropathic causes of ocular surface discomfort may play a separate or synergistic role in the development of symptoms in some patients. Most cases of early post-operative dry eye symptoms resolve with appropriate management, which includes optimizing ocular surface health before and after surgery. Severe symptoms or symptoms persisting after 9 months rarely respond satisfactorily to traditional treatment modalities and require aggressive management. This review covers current theories of post-LASIK dry eye disease, pathophysiology, risk factors, and management options for this disease spectrum of post-LASIK tear dysfunction and neuropathic pain.

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Effect of myopic LASIK on human corneal sensitivity1 1The authors have no financial or proprietary interest related to any methods or materials described herein.

Cited by 54 publications

References 13 publications

Treatment of chronic dry eye: focus on cyclosporine

Treatment of chronic dry eye: focus on cyclosporine

Evaluation of transcutaneous electrical simulation to improve recovery from corneal hypoesthesia after LASIK

Post-LASIK Tear Dysfunction and Dysesthesia

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