Treatment of chronic dry eye: focus on cyclosporine

Kymionis, George D.; Bouzoukis, Dimitrios I; Diakonis, Vasilios F.; Siganos, Charalambos S.

doi:10.2147/opth.s1409

Cited by 79 publications

(63 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 Studies show that topical administration of CsA 0.05% significantly increases tear production, decreases ocular surface damage and dry eye symptoms. 30,31 Conjunctival epithelial biopsies from these patients show decreased molecular markers of immune activation and increased conjunctival goblet cell density. 32,33 Topical cyclosporine therapy by its antiinflammatory effect results in a decrease in ocular surface inflammation and hence can have a beneficial effect on the corneal nerve regeneration.…”

Section: Discussionmentioning

confidence: 99%

Topical cyclosporine to control ocular surface disease in patients with chronic glaucoma after long-term usage of topical ocular hypotensive medications

Saini

Dhiman

Dada

et al. 2015

Eye

View full text Add to dashboard Cite

Purpose To evaluate changes in ocular surface and central corneal sub-basal nerve fiber layer (SBNFL) after topical cyclosporin therapy in chronic glaucoma patients on long-term topical antiglaucoma therapy. Methods A prospective comparative study of ocular surface evaluation of chronic glaucoma patients on long-term topical therapy treated concurrently with a topical cyclosporine 0.05% twice daily for 6 months and controls was done. The study parameters evaluated at recruitment and at the 6-month follow-up included details of topical antiglaucoma medications, visual acuity, intraocular pressure, ocular surface evaluation parameters (TBUT, Schirmers I, ocular surface staining scores and ocular surface disease (OSD) index score (OSDI)), central corneal sensation (Cochet Bonnett aesthesiometer), and central confocal microscopy to study the SBNFL density (SBNFLD). Results Thirty-two eyes of 16 patients with chronic glaucoma and 30 eyes of 15 normal subjects as controls were studied. Mean TBUT, pre/post CsA treatment was 8.67 ± 3.01/12.24 ± 1.83 s (P = 0.007). Mean conjunctival/corneal staining scores pre/post CsA treatment were 3.38 ± 1.93/1.50 ± 0.718 (P = 0.00) /5.19 ± 1.82/1.81 ± 0.78 (P = 0.098), respectively. Mean OSDI pre/post CsA treatment scores were 30.63 ± 14.61/14.76 ± 6.06 (P = 0.007). Mean corneal sensations scores pre/post CsA treatment were 4.64 ± 0.46/4.94 ± 0.39 (P = 0.002). Central corneal SBNFLD pre and post CsA treatment was 8811.35 ± 2985.29/10335.13 ± 4092.064 μm/mm 2 (P = 0.0001).Conclusions Schirmer's test, ocular surface staining scores, OSDI, corneal sensations, and corneal SBNFLD showed a statistically significant improvement following a 6-month concurrent topical CsA therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Topical cyclosporine to control ocular surface disease in patients with chronic glaucoma after long-term usage of topical ocular hypotensive medications

Saini

Dhiman

Dada

et al. 2015

Eye

View full text Add to dashboard Cite

show abstract

“…This implies that inflammation may be involved in the pathogenesis of dry eye associated with TO. In addition, anti-inflammatory or anti-cytokine therapy may be effective for the treatment of such cases (Brignole et al, 2000;Pflugfelder, 2004;De Paiva et al, 2006;Cordero-Coma et al, 2007;Kymionis et al, 2008;Pflugfelder et al, 2008;Ridder, 2008;Goyal et al, 2009;Gürdal et al, 2010). Anti-TNF-a agents, cytokine receptor antibodies, and IFN-a2a are the routinely used biologics (Jap and Chee, 2008).…”

Section: Discussionmentioning

confidence: 99%

Immunological impression cytology of the conjunctival epithelium in patients with thyroid orbitopathy-related dry eye

Hsu¹,

Lee²,

Chang³

et al. 2016

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Thyroid orbitopathy (TO) is an autoimmune disease that is complicated by ocular surface disorders, leading to discomfort. Dry eye is very prevalent in patients with TO. Recent studies on the pathogenesis of dry eye have focused on the inflammatory process, and some supporting evidence has been discovered. Because TO is a disorder of autoimmune origin, we assumed that the association between TO and dry eye is related to inflammation. Inflammation of the ocular surface in TO-related dry eye has not been well studied. In this study, we assessed cellular inflammation of the ocular surface and the cytokine profiles in patients with TO-related dry eye. Conjunctival impression cytology (CIC) was assessed with an immunofluorescent assay. TO-related dry eye was diagnosed by using the Schirmer test, tear break-up time, thyroid function, and clinical signs. CIC was combined with immunological staining of interleukin-1a (IL-1a), IL-1b, and IL-6. The immunological impression cytology (IC) grade was compared to the clinical activity score of TO. All TO patients with dry eye were positive for IL-1a, IL-1b, and IL-6. However, the normal controls were also positive for IL-1a. A trend was observed between the clinical inflammatory score and immunological IC grade. This study was the first to delineate the immunological IC of TO-related dry eye. Our study aimed to investigate the pathogenesis of dry eye in TO. Our findings suggest that the conjunctival cytokines IL-1a, IL-1b, and IL-6 may play a role. The results of this study will be useful for future studies of additional inflammatory cytokines, and the levels of these cytokines could be used as an outcome to assess the efficacy of treatment, such as anti-cytokine or immunosuppression therapy, in patients with TOrelated dry eye or other ocular surface inflammatory disorders.

show abstract

“…[15] Anti-inflammatory therapy is considered to be the causative therapeutic approach in the treatment of dry eye, since its objective is to interrupt the inflammatory cascade. [16,17] Severe cases require surgical management like punctual occlusion and tarsorraphy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Dry Eye in Post - Menopausal Women

Pujari¹,

Salagar²,

Bagare³

2015

jemds

View full text Add to dashboard Cite

Dry eye refers to a heterogeneous group of conditions all characterized by inadequate lubrication of ocular surface. Dry eye is a potentially serious and chronic condition. It may severely limit a person's activity, and in extreme cases cause blindness. Postmenopausal dry eye syndrome has frustrated patients, researchers and clinicians due to the paucity of successful treatment options and difficulty in assessing efficacy of treatment modalities. Hence early detection and treatment is necessary. AIM: This study is to assess the prevalence of dry eye in postmenopausal women to prevent complications by early detection and management. MATERIAL AND METHODS: In this prospective study, 100 subjects were included in the study. Informed written consent was obtained from all patients. Ethical committee approval was taken. The study was conducted in Basaweshwar teaching and general hospital (MR Medical college) Kalburgi Karnataka between January 2014 to June 2014. Hundred postmenopausal women were categorized based on age of the patients into three groups: Group 1: 45-55 years, Group 2: 55-65 years, Group 3: 65-75 years. They were also classified based on: 1.Occupation, 2.Rural/urban dwelling, 3. Laterality of dry eye. RESULTS: In our study, most commonly dry eye manifested in 65-75 years age group(66.6)%, and more commonly seen in rural population(65%), and in people with outdoor occupation in all age group, and bilateral in all age group. CONCLUSION: Our study was compared with other studies on dry eye, and results were found to be in comparison with them. Hence dry eye needs to be periodically evaluated and to be treated accordingly.

show abstract

Treatment of chronic dry eye: focus on cyclosporine

Cited by 79 publications

References 59 publications

Topical cyclosporine to control ocular surface disease in patients with chronic glaucoma after long-term usage of topical ocular hypotensive medications

Topical cyclosporine to control ocular surface disease in patients with chronic glaucoma after long-term usage of topical ocular hypotensive medications

Immunological impression cytology of the conjunctival epithelium in patients with thyroid orbitopathy-related dry eye

Prevalence of Dry Eye in Post - Menopausal Women

Contact Info

Product

Resources

About