Effect of mydriasis and different field strategies on digital image screening of diabetic eye disease

Abstract

Aims: To assess the effects of (1) mydriasis and (2) single versus three field photography on screening for diabetic eye disease using digital photography Method: Slit lamp examination findings were compared to digital fundal photographs for the detection of any retinopathy and for referable retinopathy in 398 patients (794 eyes). A Topcon TRC-NW6S digital non-mydriatic fundus camera was used. Three photographic strategies were used: undilated single field, dilated single field, and dilated multiple fields. The photographs were presented in random order to one of two retinal screeners. For the single field photographs the screeners were masked to the use of mydriatics. In 13% of fundal photographs, grading was performed by both, rather than just one grader. Results: Mydriasis reduced the proportion of ungradable photographs from 26% to 5% (p,0.001). Neither mydriasis nor three field photography improved the sensitivity or specificity for the detection of any retinopathy or of referable retinopathy when compared with undilated single field photography. The sensitivity and specificity for detecting referable retinopathy using undilated single field photography was 77% (95% CI 71 to 84) and 95 % (95% CI 93 to 97) respectively. Using dilated single field photography the figures were 81% (95% CI 76 to 87) and 92% (95% CI 90 to 94) respectively. Using dilated three field photography the figures were 83% (95% CI 78 to 88) and 93% (95% CI 91 to 96) respectively. Intergrader reliability for the detection of referable retinopathy in gradable photographs was excellent (Kappa values 0.86-1.00). Conclusions: Mydriasis reduces the technical failure rate. Mydriasis and the three field photography as used in this study do not increase the sensitivity or specificity of detecting diabetic retinopathy.

Angle closure glaucoma in the Northern Ireland Diabetic Retinopathy Screening Programme

“…We are also pleased to report that the visual outcomes were satisfactory, possibly due to the prompt presentations and timely treatments, thereby ensuring that minimal harm was done by the screening process in line with World Health Organisation standards. 5 Murgatroyd et al 6 have shown that mydriasis with tropicamide improves the screening process by reducing the number of ungradable photographs from 26 to 5% in retinopathy screening.…”

Estudio Granada sobre retinopatía diabética: Cribado de 8.244 pacientes diabéticos. I

“…El programa ha tenido un impacto claro, aunque no cuantificado en este artí-culo, en la reducción del número de complicaciones de la retinopatía diabética atendidas en nuestras urgencias y en el número de vitrectomias realizadas en nuestro hospital secundarias a esta patología. Los porcentajes de retinografías sin midriasis, no valorables, oscilan entre el 9% y el 26% (23,24,25). Este porcentaje de exploraciones no útiles se reduce del 1,4% al 8% cuando se realiza con retinógra-fos de 45º en midriasis farmacológica (25,26).…”

“…Los porcentajes de retinografías sin midriasis, no valorables, oscilan entre el 9% y el 26% (23,24,25). Este porcentaje de exploraciones no útiles se reduce del 1,4% al 8% cuando se realiza con retinógra-fos de 45º en midriasis farmacológica (25,26). Estos enfermos no valorables necesitan un examen posterior por un oftalmólogo.…”

Progressive changes in diabetics and their management

“…Nevertheless, photographic screening with centralised reading centres is rapidly becoming the most popular screening modality in the UK. 12 …”