Effect of Mucuna pruriens (Linn.) on mitochondrial dysfunction and DNA damage in epididymal sperm of streptozotocin induced diabetic rat

Suresh, S.; Prithiviraj, Elumalai; Lakshmi, N. Naga; Mohanraj, K.; Lakshmanan, Ganesh; Prakash, Seppan

doi:10.1016/j.jep.2012.10.030

Cited by 55 publications

(52 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Researchers observed in previous studies that diabetes increases lipid peroxidation in several organs and changes the activities of antioxidant enzymes (Shanmugam et al 2011;Suresh et al 2013). There are also studies about diabetes causes histological alterations in different tissues (Degirmenci et al 2005;Arnal et al 2010;Shanmugam et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence that, besides the long term diabetes complications, which include accelerated atherosclerosis, renal failure caused by glomerular injury and neuropathy (Arnal et al 2010). Supplementation of antioxidants was shown to reduce oxidative damage caused by chemicals and diabetes (Suresh et al 2013;Uzun and Kalender 2013;Baş et al 2015). Lycopene is the most extensive carotenoid which found in diet especially in tomato.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Pandır

Ünal

Baş

2016

Braz. arch. biol. technol.

View full text Add to dashboard Cite

Furan is a food and environmental contaminant and a potent carcinogen in animals. Lycopene is one dietary carotenoid found in fruits such as tomato, watermelon and grapefruit. The present study was designed to explore the protective effect of lycopene against furan-induced oxidative damage in streptozotocin (STZ)-induced diabetic rat kidney. At the end of the experimental period (28 days), we found that lycopene markedly decreased the malondialdehide (MDA) levels in the kidney, urea, uric acid and creatinine levels in the serum of furan-treated rats. The increase of histopathology in the kidney of furan-treated rats were effectively suppressed by lycopene. Furthermore, lycopene markedly restored superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in the kidney of furan-treated rats.In conclusion, these results suggested that lycopene could protect the rat kidney against furan-induced injury by improving renal function, attenuating histopathologic changes, reducing MDA production and renewing the activities of antioxidant enzymes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Pandır

Ünal

Baş

2016

Braz. arch. biol. technol.

View full text Add to dashboard Cite

show abstract

“…Several studies suggest that oxidative stress appears to be the key determinant of toxicity induced by furan and diabetes both in vivo and in vitro (29,30). Recent in vivo studies in furan treated animals showed reactive oxygen species (ROS) formation and stimulation of lipid peroxidation (LPO) promoting the function of oxidative stress in the toxicity of furan (31,32).…”

Section: Discussionmentioning

confidence: 99%

“…Shanmugam et al (40) and Suresh et al (29) observed that diabetes increased LPO and changed antioxidant enzyme activities. There are also studies confirming that diabetes causes histological alterations in different tissues (40).…”

Section: Conflict Of Interestmentioning

confidence: 99%

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Baş

Pandır

Kalender

2016

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Furan forms as a result of thermal treatment of food and induces harmful effects on organisms. In our work, lycopene, furan, and a combination of the two were given to diabetic male rats for 28 days. Hematological changes, total protein and cholesterol, triglyceride, and albumin levels, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities of the serum, malondialdehyde levels, glutathione peroxidase, catalase, glutathione-S-transferase, superoxide dismutase activities, DNA damage in liver tissues and hepatic histopathological alterations were compared to a control group. There were significant changes in the liver function tests, DNA damage, activities of antioxidant enzymes, and malondialdehyde levels between diabetic control and non-diabetic control groups, between diabetic control and diabetic lycopene groups, and also between diabetic furan and diabetic control groups. In diabetic lycopene and diabetic furan + lycopene treated groups we designated the preventive effects of lycopene against diabetes and furan, however, on the analysed parameters only. In spite of some pathological alterations designated in diabetic furan treated group's liver, fewer pathological alterations were observed in furan+lycopene treated groups at the end of week 4. Consequently, lycopene significantly reduced furan-and diabetes-induced toxicity in rat liver.

show abstract

“…[18,19] M. pruriens seeds are used at a dose of 500 mg/kg to reduce plasma glucose level. [20] These and other data demonstrated that the amount of seeds necessary to obtain a significant antidiabetic effect contain a total of approximately 7 mg of d-chiro-inositol. The antidiabetic properties of M. pruriens seed ethanol/water 1:1 extract are most likely due to d-chiroinositol and its galacto derivatives.…”

Section: Antidiabetic Activitymentioning

confidence: 84%

Untitled

Upadhyay

2017

IJGP

View full text Add to dashboard Cite

The plant Mucuna pruriens (Fabaceae) is an established herbal drug, widely known as "velvet bean," a vigorous annual climbing legume originally from Southern China and Eastern India, where it was at one time widely cultivated as a green vegetable crop. It has been shown that its seeds are potentially of substantial medicinal importance. The ancient Indian medical system, Ayurveda, traditionally used M. pruriens, even to treat such things as Parkinson's disease. M. pruriens has been shown to have antiparkinson and neuroprotective effects, which may be related to its antioxidant activity and used for the management of male infertility, nervous disorders, and also as an aphrodisiac.

show abstract

Effect of Mucuna pruriens (Linn.) on mitochondrial dysfunction and DNA damage in epididymal sperm of streptozotocin induced diabetic rat

Cited by 55 publications

References 56 publications

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Untitled

Contact Info

Product

Resources

About