Effect of Mucuna pruriens and Millettia pinnata (Fabaceae) minerals on some isolated organs of envenomated and treated Oryctolagus cuniculus

Abstract

The general objective of this study was to evaluate the antivenom effect of minerals from two plants on some vital organs (heart, liver, kidneys and lungs) of rabbits. It was carried out with 36 rabbits (19 males and 17 females) divided into portions E1, E2 and E3. E1 consisted of 2 control lots (3 males and 3 females), and 1 experimental lot (2 males and 1 female). E2 comprised 7 batches of rabbits (2 males and 1 female). E3 consisted of 2 batches of 3 females. Naja nigricollis venom was injected for approximately 20-30 minutes to the animals in the experimental batch of E1, and to those in E2 and E3. Then, E2 and E3 were treated preventively and curatively with minerals, respectively. After the determination of their biochemical and hematological parameters, they were necropsied separately and then their organs were removed, weighed and their appearance was studied. The study revealed that the venom of Naja nigricollis was the cause of death of all the animals of the experimental batch of E1. On the other hand, the use of P2 and P3 as a preventive measure was able to save 1 out of 3 and 3 individuals respectively from the venom. As for P3 as a curative measure, it kept alive 2 out of 3 individuals against the venom. Thus, for the development of anti-venomous phytomedicine, it would be advisable to use the minerals from P3 (ash of Millettia pinnata).
 Keywords: Antivenomous, minerals, Millettia pinnata, Naja nigricollis, phytomedicine