Effect of Motor Imagery in Children with Unilateral Cerebral Palsy: fMRI Study

Chinier, Eva; Nguyen, Sylvie; Lignon, G.; Minassian, Aram Ter; Richard, Isabelle; Dinomais, Mickaël

doi:10.1371/journal.pone.0093378

Cited by 23 publications

(13 citation statements)

References 47 publications

(58 reference statements)

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“…These findings are partly in contrast with other studies on MI in UCP children (25, 26, 72), which suggest a general deficit in MI and motor planning for hemiparetic CP children with motor deficits on the right side compared with the left one. For instance, Chinier et al (72) showed that only UCP patients with early lesions of the right hemisphere were able to perform MI. A plausible explanation for this discrepancy could be the specificity of MI modality, explicitly requiring participants to imagine themselves performing the action in a first-person perspective.…”

Section: Discussioncontrasting

confidence: 99%

Explicit Motor Imagery for Grasping Actions in Children With Spastic Unilateral Cerebral Palsy

et al. 2019

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Background: Motor Imagery (MI) refers to mental simulation of a motor action without producing any overt movement. Previous studies showed that children with Unilateral Cerebral Palsy (UCP) are impaired in implicit MI, as demonstrated by the performance of Hand Laterality Judgment tasks. The aim of this study was to examine the specificity of explicit MI deficits in UCP children. Methods: A group of UCP children ( n = 10; aged 9–14) performed a mental chronometry task consisting in grasping an object and placing it into a container, or in imagining to perform the same action. As control, a group of typically developing (TD) children, matched by age, performed the same task. Movement durations for executed and imagined trials were recorded. A subgroup of 7 UCP children and 10 TD children also underwent a session of functional MRI to examine the activation of parieto-frontal areas typically associated to MI processes, during the imagination of reaching-grasping actions performed with the paretic hand. Results: Behavioral results revealed the existence of a correlation between executed and imagined movement durations both in TD and UCP groups. Moreover, the regression analysis in TD children showed that higher scores in mental chronometry tasks were positively correlated to increased bilateral activation of the intraparietal sulcus (IPS), superior parietal lobule (SPL), and dorsal premotor (PMd) cortex. A similar analysis revealed in the UCP group a positive correlation between a higher score in the mental chronometry task and bilateral activations of IPS, and to activation of contralesional, right PMd, and putamen during imagination of grasping movements. Conclusions: These results provide new insights on the relationship between MI capacity and motor deficits in UCP children, suggesting the possibility of the use of explicit MI training to improve patient's upper limb motor functions.

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Section: Discussioncontrasting

confidence: 99%

Explicit Motor Imagery for Grasping Actions in Children With Spastic Unilateral Cerebral Palsy

et al. 2019

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“…Cerebral palsy (CP) encompasses a range of motor and postural disorders due to nonprogressive disturbances in fetal or infant development. Among all children with CP, approximately one-third have hemiplegic cerebral palsy caused by asymmetric lesion on a developing brain [7]. Dyskinetic CP (DCP), dominated by dystonic and choreoathetoid CP, is the second most common CP subtype, which is characterized by abnormal patterns of posture or movement, accompanied by involuntary, recurring, and uncontrolled and occasionally stereotyped movements [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Aberrant Interhemispheric Functional Organization in Children with Dyskinetic Cerebral Palsy

Qin

Sun

Zhang

et al. 2019

BioMed Research International

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Background. Hemispheric asymmetry is one fundamental principle of neuronal organization. Interhemispheric connectivity and lateralization of intrinsic networks in the resting-state brain demonstrate the interhemispheric functional organization and can be affected by disease processes. This study aims to investigate the interhemispheric organization in children with dyskinetic cerebral palsy (DCP) based on resting-state functional MRI (fMRI). Methods. 24 children with DCP and 20 healthy children were included. Voxel-mirrored homotopic connectivity (VMHC) was calculated to detect the interhemispheric connectivity, and the lateralization of the resting-state networks was performed to examine the asymmetry of the intrinsic networks of brain. Results. Decreased interhemispheric connectivity was found at visual, motor, and motor-control related regions in children with DCP, while high cognitive related networks including the central executive network, the frontoparietal network, and the salience network represented decreased asymmetry in children with DCP. Abnormal VMHC in visual areas, as well as the altered lateralization in inferior parietal lobule and supplementary motor area, showed correlation with the gross motor function and activities of daily living in children with DCP. Conclusion. These findings indicate that the interhemispheric functional organization alteration exists in children with DCP, suggesting that abnormal interhemispheric interaction may be a pathophysiological mechanism of motor and cognitive dysfunction of CP.

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“…По мнению авторов, диффузионная тензорная визуализация у детей с данной патологией позволяет выявить не только структурные нарушения головного мозга, но и эпилептогенный очаг [54]. Функциональная МРТ дает возможность выявить дисфункцию нейронных сетей и кортикальных взаимосвязей между различными отделами головного мозга при ДЦП [55,56].…”

Section: прогностическое значение мр-находокunclassified

Possibilities of Magnetic Resonance Imaging of the Brain in Infantile Cerebral Palsy

Белова

Шейко

Клюев

et al. 2018

Vopr. sovr. pediatr.

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Infantile cerebral palsy (ICP) is the main cause of childhood disability and is characterized by a non-progressive lesion and/or impaired development of the brain in a foetus or newborn. Magnetic resonance imaging (MRI) is a modern non-invasive method with extensive capabilities for diagnosing brain damage in ICP. The review focuses on anatomical structural MR patterns of brain damage in ICP and gives the present-day classification of MR changes in this disease. The role of MRI in determining the duration of brain damage in ICP has been considered. Data on the ratio of ICP phenotypes to pathological MR findings has been presented. Neuroimaging prognostic biomarkers are discussed. It is emphasized that many questions regarding the prognostic significance of MR findings remain unresolved; prospects are associated with the use of new MRI modalities such as functional and diffusiontensor MRI.

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Effect of Motor Imagery in Children with Unilateral Cerebral Palsy: fMRI Study

Cited by 23 publications

References 47 publications

Explicit Motor Imagery for Grasping Actions in Children With Spastic Unilateral Cerebral Palsy

Explicit Motor Imagery for Grasping Actions in Children With Spastic Unilateral Cerebral Palsy

Aberrant Interhemispheric Functional Organization in Children with Dyskinetic Cerebral Palsy

Possibilities of Magnetic Resonance Imaging of the Brain in Infantile Cerebral Palsy

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